driver.custom.json

[
    {
        "chr": "chr2",
        "pos": 47806320,
        "ref": "G",
        "alt": "A",
        "gene": "MSH6",
        "category": "mutational",
        "transcript_consequence": "c.3763G>A",
        "protein_mutation": "p.Asp1255Asn",
        "allele_fraction": "0.238095",
        "mutation_type": "missense_variant"
    },
    {
        "chr": "chr6",
        "pos": 157133136,
        "ref": "G",
        "alt": "C",
        "gene": "ARID1B",
        "biallelic": "yes",
        "category": "mutational",
        "transcript_consequence": "c.2480G>C",
        "protein_mutation": "p.Gly827Ala",
        "allele_fraction": "0.977273",
        "mutation_type": "missense_variant"
    },
    {
        "chr": "chr8",
        "pos": 38428420,
        "ref": "G",
        "alt": "A",
        "gene": "FGFR1",
        "category": "mutational",
        "transcript_consequence": "c.473C>T",
        "protein_mutation": "p.Ser158Leu",
        "allele_fraction": "1",
        "mutation_type": "missense_variant"
    },
    {
        "chr": "chr13",
        "pos": 32339132,
        "ref": "G",
        "alt": "T",
        "gene": "BRCA2",
        "category": "mutational",
        "biallelic": "no",
        "transcript_consequence": "c.4777G>T",
        "protein_mutation": "p.Glu1593Ter",
        "allele_fraction": "0.447368",
        "mutation_type": "missense_variant"
    },
    {
        "chr": "chr17",
        "pos": 7675088,
        "ref": "C",
        "alt": "T",
        "gene": "TP53",
        "category": "mutational",
        "biallelic": "yes",
        "transcript_consequence": "c.524G>A",
        "protein_mutation": "p.Arg175His",
        "allele_fraction": "0.977273",
        "mutation_type": "missense_variant"
    },
    {
        "chr": "chrX",
        "pos": 77681733,
        "ref": "T",
        "alt": "C",
        "gene": "ATRX",
        "category": "mutational",
        "biallelic": "yes",
        "transcript_consequence": "c.3523A>G",
        "protein_mutation": "p.Lys1175Glu",
        "allele_fraction": "0.944444",
        "mutation_type": "missense_variant"
    },
    {
        "gene": "CDKN2A",
        "chr": "chr9",
        "pos": 21981527,
        "category": "deletion"
    },
    {
        "gene": "MET",
        "chr": "chr7",
        "pos": 116735291,
        "category": "amplification"
    },
    {
        "gene": "PTEN",
        "chr": "chr10",
        "pos": 87917284,
        "category": "deletion",
        "biallelic": "yes"
    }
]