diff --git a/docs/notebooks/talk2biomodels/descriptions_output.json b/docs/notebooks/talk2biomodels/descriptions_output.json new file mode 100644 index 00000000..ba230b76 --- /dev/null +++ b/docs/notebooks/talk2biomodels/descriptions_output.json @@ -0,0 +1 @@ +{"Ab_R": "The paper does not provide a specific description of \"Ab_R\" species, but it discusses therapeutic monoclonal antibodies targeting IL-6 signaling in Crohn's disease, particularly mentioning tocilizumab (anti-IL-6R\u03b1 antibody) and its pharmacological effects in the context of immune regulation and inflammatory responses. The study focuses on multiscale modeling of IL-6 signaling pathways rather than detailing a specific species labeled as \"Ab_R.\"", "Ab_sR_IL6{gut}": "The description of Ab_sR_IL6{gut} species is not explicitly provided in the text you have shared. Please refer to the specific sections of the original paper that detail species descriptions to find the information needed.", "Ab_sR_IL6{liver}": "Ab_sR_IL6{liver} refers to the soluble IL-6 receptor (sIL-6R\u03b1) in the liver, which is implicated in the IL-6 signaling pathway. The liver's involvement is critical due to its role in the upregulation of acute-phase proteins associated with inflammatory conditions like Crohn\u2019s disease. In the context of the multiscale model of IL-6\u2013mediated immune regulation in Crohn's disease, the liver compartment is designed to exchange soluble components with the gastrointestinal tract through blood circulation, therefore emphasizing the interconnectedness of these organs in the pathological process influenced by IL-6 signaling.", "Ab_sR_IL6{serum}": "Ab_sR_IL6{serum} is a monoclonal antibody that targets the interleukin-6 receptor (IL-6R\u03b1), functioning to inhibit IL-6 signaling pathways involved in the inflammatory processes underlying diseases such as Crohn's disease.", "Ab_sR{gut}": "Ab_sR{gut} is a species representing the soluble interleukin-6 receptor (sIL-6R) in the gastrointestinal tract, which is involved in IL-6 mediated signaling and immune regulation in Crohn's disease.", "Ab_sR{liver}": "**Ab_sR{liver}**: The liver compartment models the role of the liver in upregulating acute-phase proteins associated with Crohn\u2019s disease, such as C-reactive protein (CRP). It is linked to the IL-6 signaling module and represents a communication channel through which the liver can respond to and modulate the effects of IL-6-mediated signaling in the gastrointestinal (GI) tract. The liver is included in the multiscale model to account for its significant impact on systemic inflammatory responses in Crohn\u2019s disease.", "Ab_sR{serum}": "The description of Ab_sR{serum} species is not explicitly provided in the text you shared.", "Ab{gut}": "The paper does not appear to provide any specific description of the Ab{gut} species. The focus of the study is on the development of a multiscale systems model of interleukin-6\u2013mediated immune regulation in Crohn\u2019s disease rather than detailing specific species or biological entities.", "Ab{liver}": "The description of Ab{liver} species is as follows:\n\n\"The second compartment models the liver, which was included for its prominent role in the upregulation of acute-phase proteins associated with Crohn\u2019s disease, such as CRP.\"", "Ab{peripheral}": "The description of Ab{peripheral} species is not explicitly stated in the provided text. Consequently, I cannot extract a specific description for \"Ab{peripheral}\" species from this paper.", "Ab{serum}": "Ab{serum} species refers to the concentration of therapeutic monoclonal antibodies measured in the serum. In the context of the study, it is used to describe the pharmacokinetic profiles of anti\u2013IL-6 or anti\u2013IL-6R\u03b1 antibodies, indicating their concentrations over time in the bloodstream as part of evaluating their effects on biomarkers such as serum C-reactive protein (CRP) in patients with Crohn's disease.", "CRP (% of baseline)": "CRP (% of baseline) for Crohn\u2019s disease patients showed a transient reduction in serum levels following treatment with anti\u2013IL-6R\u03b1 antibody, returning to baseline levels by the end of each dosing cycle in the 4-week intravenous administration schedule. The model demonstrated a sustained reduction in serum CRP levels under the 2-week intravenous dosing schedule, although it underestimated the reduction compared to clinical data.", "CRP Suppression (%)": "The description of CRP Suppression (%) for different species is not explicitly listed in the provided text. Please let me know if there is another part of the document or specific information you would like to extract.", "CRPExtracellular": "CRPExtracellular species: C-reactive protein (CRP) is an acute-phase protein that is produced by the liver and is involved in the immune response. It is upregulated in inflammatory conditions, including Crohn's disease, where it can serve as a biomarker for disease activity. In the context of the model, CRP is linked to IL-6 signaling and is produced in response to IL-6 activity, contributing to the inflammatory process associated with the disease.", "CRP{liver}": "CRP (C-reactive protein) is an acute-phase protein whose serum concentrations are reported to increase in patients with Crohn's disease. The production and regulation of CRP are influenced by interleukin-6 (IL-6) signaling. In Crohn's disease, enhanced IL-6 signaling results in elevated levels of CRP, which can serve as a biomarker for inflammation and disease activity.", "CRP{serum}": "**CRP (C-reactive protein) in serum: Serum concentrations of CRP are reported to be significantly elevated in patients with Crohn\u2019s disease, with levels around 7 mg/l compared to 1 mg/l in healthy subjects. This increase is thought to be driven by elevated interleukin-6 (IL-6) levels and is associated with the inflammatory response in the disease.**", "geneProduct": "The species involved in the gene product descriptions in this paper pertain to humans (Homo sapiens).", "gp130{gut}": "gp130 is a coreceptor that plays a crucial role in interleukin-6 (IL-6) signaling. It is almost ubiquitously expressed and can form a heterotrimeric complex with membrane-bound IL-6 and IL-6 receptor (IL-6R\u03b1) or the soluble IL-6 receptor (sIL-6R\u03b1). This complex, when dimerized, activates downstream signaling pathways involving Janus kinase (Jak) family proteins and signal transducer and activator of transcription 3 (STAT3). Additionally, gp130 can exist in a soluble form (sgp130), which acts as a natural inhibitor of IL-6 trans-signaling by sequestering the IL-6/sIL-6R\u03b1 complex.", "gp130{liver}": "The paper does not explicitly provide a distinct description under \"gp130{liver} species.\" It focuses on the multiscale model of IL-6\u2013mediated immune regulation and discusses the role of gp130 within the context of IL-6 signaling pathways and Crohn's disease. It mentions that gp130 is a coreceptor involved in the formation of the hexameric IL-6 receptor complex and that it is almost ubiquitously expressed, including in the liver. There is discussion about the soluble form of gp130 (sgp130) acting as a natural inhibitor of trans-signaling but no specific isolated description labeled \"gp130{liver} species.\"", "IL6{gut}": "IL6{gut} refers to interleukin-6 signaling occurring within the gastrointestinal (GI) tract, which plays a significant role in Crohn's disease. This signaling pathway involves both classical and trans-signaling mechanisms, contributing to the proinflammatory environment in the mucosal layer. In the context of Crohn's disease, IL-6 increases T-cell survival and apoptosis resistance, with levels detected in both intestinal mucosa and serum. This signaling is linked to the regulation of various immune responses and acute-phase protein expression, making it a crucial target for therapeutic strategies.", "IL6{liver}": "IL6{liver} is included in a multiscale model of IL-6-mediated immune regulation in Crohn's disease, which describes the role of IL-6 signaling in the liver, particularly its involvement in the upregulation of acute-phase proteins such as C-reactive protein (CRP). The liver compartment models the dynamics of IL-6 signaling in relation to the disease pathology and pharmacological interventions, allowing for the study of drug effects on systemic markers associated with Crohn\u2019s disease.", "IL6{serum}": "Serum IL-6 is a pro-inflammatory cytokine that is increased in intestinal mucosa and peripheral blood in Crohn's disease. It signals through both classical and trans-signaling pathways, activating the gp130 co-receptor and leading to the phosphorylation of STAT3, contributing to T-cell survival and apoptosis resistance. The serum concentration of IL-6 is thought to drive increases in other biomarkers like C-reactive protein (CRP) and soluble IL-6 receptor (sIL-6R) in Crohn's disease patients.", "pSTAT3{gut}": "pSTAT3 in the gut (pSTAT3{gut}) is measured in arbitrary units (au) and exhibits a fold change from healthy subjects to Crohn's disease patients, where levels increase from 1 au in healthy subjects to 3 au in Crohn's disease patients.", "pSTAT3{liver}": "pSTAT3{liver} is a phosphorylated form of signal transducer and activator of transcription 3 (STAT3) located in the liver. It is involved in the IL-6 signaling pathway, contributing to the modulation of gene expression and biological responses in the context of inflammatory processes, such as those observed in Crohn's disease. In Crohn's disease patients, increased levels of pSTAT3 have been noted in colon biopsies, potentially driven by elevated IL-6 concentrations and signaling through IL-6/sIL-6R\u03b1 complexes.", "R": "The description of R species from the paper is: \"The multiscale model comprises three overlapping structural modules spanning spatial scales from cellular to organ levels. The first module describes events at the cellular level and consists of a reduced model of IL-6\u2013mediated signal transduction. The second module is made up of target organs relevant in Crohn\u2019s disease, and the first module (the cell signaling model) is embedded within these organs. The third and final module is a general PK model for monoclonal antibodies, including specific target binding that is linked to the first two modules to study the action of drug on the system.\"", "R_IL6": "R_IL6 species refers to the interleukin-6 (IL-6) signaling module within the multiscale systems model developed for Crohn's disease. It is a critical component of the model representing the molecular interactions and signaling dynamics associated with IL-6-mediated immune regulation. This module integrates processes such as IL-6 receptor binding, activation of the Janus kinase-signal transducer and activator of transcription (Jak-STAT) pathway, and downstream effects on biomarker expression linked to Crohn's disease pathology.", "R_IL6_gp130{gut}": "R_IL6_gp130{gut} represents the interleukin-6 signaling complex involving gp130 in the gastrointestinal tract, which is implicated in the inflammatory response observed in Crohn's disease.", "R_IL6_gp130{liver}": "R_IL6_gp130{liver} represents the liver compartment in a multiscale systems pharmacology model investigating interleukin-6 (IL-6) signaling in Crohn's disease. The model integrates intracellular signaling with the dynamics of pharmacological markers, focusing on the liver's role in the upregulation of acute-phase proteins, such as C-reactive protein (CRP), which are associated with the inflammatory processes in Crohn's disease. The liver compartment communicates with other organ compartments, allowing for the exchange of soluble components through blood serum, and is assumed to consist of a homogeneous population of cells with identical signaling dynamics.", "Reactive{gut}": "Reactive{gut} species refer to various inflammatory mediators and cytokines involved in the immune response in the gastrointestinal tract, particularly in diseases like Crohn's disease. These include interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), C-reactive protein (CRP), and phosphorylated signal transducer and activator of transcription 3 (pSTAT3). These species are elevated in Crohn's disease and play a crucial role in driving the inflammatory processes and immune regulation within the gut environment.", "Reactive{liver}": "**Reactive{liver} species**: This species represents the liver's role in the upregulation of acute-phase proteins associated with Crohn\u2019s disease, such as C-reactive protein (CRP). It is part of the multiscale systems model that integrates IL-6 signaling dynamics with organ-level kinetics, reflecting the liver's involvement in the systemic inflammatory response characterizing the disease.", "sgp130{gut}": "The coreceptor gp130 can also exist in a soluble form (sgp130), acting as a natural inhibitor of trans-signaling by sequestering the IL-6/sIL-6R\u03b1 complex.", "sgp130{liver}": "The coreceptor gp130 can also exist in a soluble form (sgp130), acting as a natural inhibitor of trans-signaling by sequestering the IL-6/sIL-6R\u03b1 complex.", "sgp130{serum}": "The coreceptor gp130 can also exist in a soluble form (sgp130), acting as a natural inhibitor of trans-signaling by sequestering the IL-6/sIL-6R\u03b1 complex.", "sR_IL6_sgp130{gut}": "sR_IL6_sgp130{gut} represents the soluble form of the interleukin-6 receptor (sIL-6R) complexed with soluble glycoprotein 130 (sgp130) in the gastrointestinal tract. This complex acts as a natural inhibitor of IL-6 trans-signaling, sequestering the IL-6/sIL-6R complex and preventing downstream signaling events associated with inflammation and immune response in the context of Crohn's disease.", "sR_IL6_sgp130{liver}": "The description of sR_IL6_sgp130{liver} species is not directly found in the provided text. Please provide a specific section from the article if you have one in mind or confirm if there is a specific aspect related to sR_IL6_sgp130{liver} you would like to inquire about.", "sR_IL6_sgp130{serum}": "The species description for sR_IL6_sgp130{serum} is as follows: It is a soluble form of the interleukin-6 receptor component gp130 that acts as a natural inhibitor of IL-6 trans-signaling by sequestering the IL-6/sIL-6R\u03b1 complex.", "sR_IL6{gut}": "sR_IL6{gut} represents the soluble interleukin-6 receptor (sIL-6R\u03b1) found in the gastrointestinal tract. It is produced through alternative gene splicing and shedding of the transmembrane IL-6 receptor. The shedding process is thought to be accelerated by proteins like C-reactive protein (CRP). The presence of sIL-6R\u03b1 in the gut contributes to IL-6 signaling, particularly through trans-signaling mechanisms important in the context of inflammatory conditions such as Crohn\u2019s disease.", "sR_IL6{liver}": "sR_IL6{liver} is a soluble form of the interleukin-6 receptor (IL-6R\u03b1) produced in the liver, which can mediate IL-6 signaling in a trans-signaling manner. It plays a role in the inflammatory response associated with Crohn's disease by interacting with IL-6 and contributing to the regulation of immune responses, potentially influencing the survival of T-cells and the secretion of chemokines.", "sR_IL6{serum}": "sR_IL6{serum} is the soluble form of the interleukin-6 receptor found in serum, which plays a critical role in mediating IL-6 signaling through the trans-signaling pathway. It is produced by alternative gene splicing and shedding of the membrane-bound IL-6 receptor, and its levels are generally elevated in conditions such as Crohn's disease, contributing to the inflammatory response.", "sR{gut}": "sR{gut} refers to the soluble form of the IL-6 receptor (sIL-6R\u03b1) in the gastrointestinal (GI) tract, which is involved in the IL-6 signaling pathway. This receptor is produced through alternative gene splicing and shedding of the membrane-bound IL-6 receptor (IL-6R\u03b1). In Crohn's disease, the levels of sIL-6R\u03b1 are reported to be elevated, contributing to the pro-inflammatory environment in the GI tract and playing a role in the pathophysiology of the disease. The interaction between IL-6 and sIL-6R\u03b1 is of particular interest for therapeutic strategies targeting IL-6-mediated signaling.", "sR{liver}": "The liver was included for its prominent role in the upregulation of acute-phase proteins associated with Crohn\u2019s disease, such as C-reactive protein (CRP).", "sR{serum}": "sR{serum}: Serum is modeled as a separate compartment representing the circulation through which organs exchange serum-soluble molecules. All molecules in this compartment have basal production and decay terms; soluble IL-6 receptor (sIL-6R\u03b1) is produced by C-reactive protein (CRP)-mediated shedding.", "STAT3{gut}": "STAT3 is a signal transducer and activator of transcription that is phosphorylated by Janus kinase (Jak) family proteins in response to interleukin-6 (IL-6) signaling. In the context of Crohn\u2019s disease, STAT3 phosphorylation (pSTAT3) is involved in enhancing T-cell survival and resistance to apoptosis in the lamina propria, contributing to the proinflammatory environment typical of the disease. The model developed in the study specifically assesses the dynamics of pSTAT3 in relation to various therapeutic strategies targeting IL-6 signaling.", "STAT3{liver}": "STAT3{liver} is involved in the IL-6 signaling pathway, where it becomes phosphorylated (pSTAT3) in response to IL-6 signaling via the IL-6/IL-6R\u03b1 complex and gp130, leading to the transcription of various gene products associated with the inflammatory response in the liver."} \ No newline at end of file diff --git a/docs/notebooks/talk2biomodels/embed_descriptions_search_ncbi.py b/docs/notebooks/talk2biomodels/embed_descriptions_search_ncbi.py new file mode 100644 index 00000000..528965e1 --- /dev/null +++ b/docs/notebooks/talk2biomodels/embed_descriptions_search_ncbi.py @@ -0,0 +1,72 @@ +import os +import json +import numpy as np +import pandas as pd +import openai +import faiss +import pickle +from dotenv import load_dotenv + +# Load API key from .env file +load_dotenv() +openai.api_key = os.getenv("OPENAI_API_KEY") + +# Define file paths +DESCRIPTIONS_FILE = "descriptions_output.json" +EMBEDDINGS_FILE = "gene_embeddings.pkl" +INDEX_FILE = "faiss_index.bin" +GENE_MAPPING_FILE = "gene_id_mapping.pkl" +OUTPUT_FILE = "species_gene_matches.csv" + + +def get_openai_embedding(text, model="text-embedding-3-large"): + """Generate text embeddings using OpenAI's API.""" + response = openai.embeddings.create(input=[text], model=model) + return np.array(response.data[0].embedding) + + +def load_faiss_index(): + """Load FAISS index and gene mapping.""" + if not os.path.exists(INDEX_FILE) or not os.path.exists(GENE_MAPPING_FILE): + raise FileNotFoundError("FAISS index or gene mapping file not found. Run the gene extraction script first.") + + index = faiss.read_index(INDEX_FILE) + with open(GENE_MAPPING_FILE, "rb") as f: + gene_id_mapping = pickle.load(f) + return index, gene_id_mapping + + +def search_species_genes(descriptions): + """Embed species descriptions and find closest gene/protein match using FAISS default L2 distance.""" + index, gene_id_mapping = load_faiss_index() + results = [] + + for species, description in descriptions.items(): + query_embedding = get_openai_embedding(description).astype("float32") + distances, indices = index.search(query_embedding.reshape(1, -1), k=1) + best_match_idx = indices[0][0] + best_match_score = distances[0][0] + best_match_gene, ncbi_id = gene_id_mapping[best_match_idx] + + print(f"Best match for {species}: {best_match_gene} (NCBI ID: {ncbi_id}, Score: {best_match_score:.4f})") + results.append({"species_name": species, "ncbi_node_id": ncbi_id}) + + return results + + +def main(): + """Main function to read descriptions, search for genes, and save results.""" + if not os.path.exists(DESCRIPTIONS_FILE): + raise FileNotFoundError("Descriptions JSON file not found!") + + with open(DESCRIPTIONS_FILE, "r") as f: + descriptions = json.load(f) + + results = search_species_genes(descriptions) + df = pd.DataFrame(results) + df.to_csv(OUTPUT_FILE, index=False) + print(f"Results saved to {OUTPUT_FILE}") + + +if __name__ == "__main__": + main() \ No newline at end of file diff --git a/docs/notebooks/talk2biomodels/embed_genes.py b/docs/notebooks/talk2biomodels/embed_genes.py new file mode 100644 index 00000000..91026c90 --- /dev/null +++ b/docs/notebooks/talk2biomodels/embed_genes.py @@ -0,0 +1,154 @@ +import os +import numpy as np +import pandas as pd +import openai +import faiss +import pickle # To save/load embeddings +from dotenv import load_dotenv +from aiagents4pharma.talk2knowledgegraphs.datasets.primekg import PrimeKG + +# Load API key from .env file +load_dotenv() +openai.api_key = os.getenv("OPENAI_API_KEY") + +EMBEDDINGS_FILE = "gene_embeddings.pkl" # File to store/reuse embeddings +INDEX_FILE = "faiss_index.bin" # FAISS index storage +GENE_MAPPING_FILE = "gene_id_mapping.pkl" # Mapping of FAISS index to gene details + + +def get_openai_embedding(text, model="text-embedding-3-large"): + """Generate text embeddings using OpenAI's API.""" + response = openai.embeddings.create(input=[text], model=model) + return np.array(response.data[0].embedding) + + +def extract_genes_from_go(go_keywords=["immune", "inflammation"]): + """Extract genes/proteins associated with GO terms (immune/inflammation).""" + primekg_data = PrimeKG(local_dir="../../../../data/primekg/") + primekg_data.load_data() + + primekg_nodes = primekg_data.get_nodes() + primekg_edges = primekg_data.get_edges() + + # STEP 1: Extract GO Terms + go_query = "|".join(go_keywords) + go_terms_df = primekg_nodes[ + (primekg_nodes["node_type"].isin(["biological_process", "molecular_function", "cellular_component"])) & + (primekg_nodes["node_name"].str.contains(go_query, case=False, na=False)) + ] + + if go_terms_df.empty: + print(f"No GO terms matching {go_keywords} found in PrimeKG!") + return None + + go_term_ids = go_terms_df.index.values + print(f"Found {len(go_term_ids)} GO terms related to {go_keywords}.") + + # STEP 2: Extract Gene-GO Relationships + gene_go_edges_df = primekg_edges[ + ((primekg_edges.head_index.isin(go_term_ids)) & (primekg_edges.tail_type == "gene/protein")) | + ((primekg_edges.tail_index.isin(go_term_ids)) & (primekg_edges.head_type == "gene/protein")) + ] + + if gene_go_edges_df.empty: + print(f"No gene-GO relationships found for {go_keywords}!") + return None + + gene_ids = np.unique( + np.concatenate([ + gene_go_edges_df[gene_go_edges_df.head_type == "gene/protein"].head_index.unique(), + gene_go_edges_df[gene_go_edges_df.tail_type == "gene/protein"].tail_index.unique() + ]) + ) + + print(f"Found {len(gene_ids)} genes/proteins linked to immune/inflammation GO terms.") + + genes_df = primekg_nodes[primekg_nodes.index.isin(gene_ids)][["node_index", "node_name", "node_id", "node_type"]] + + print(f"Extracted {len(genes_df)} gene/protein nodes from PrimeKG based on immune/inflammation GO terms.") + return genes_df + + +def compute_embeddings_for_genes(genes_df): + """Compute and save embeddings for genes, or load from cache if available.""" + if os.path.exists(EMBEDDINGS_FILE): + print("Loading precomputed embeddings...") + with open(EMBEDDINGS_FILE, "rb") as f: + return pickle.load(f) + + print("🔹 Computing embeddings for all genes/proteins...") + embeddings = {} + + for idx, row in genes_df.iterrows(): + try: + embedding = get_openai_embedding(row["node_name"]) + embeddings[row["node_index"]] = embedding + except Exception as e: + print(f"Failed to embed: {row['node_name']} - {e}") + + # Save embeddings + with open(EMBEDDINGS_FILE, "wb") as f: + pickle.dump(embeddings, f) + + print(f"Saved {len(embeddings)} gene embeddings.") + return embeddings + + +def build_faiss_index(genes_df, embeddings): + """Build and save a FAISS index for fast similarity search.""" + if os.path.exists(INDEX_FILE) and os.path.exists(GENE_MAPPING_FILE): + print("Loading FAISS index from file...") + index = faiss.read_index(INDEX_FILE) + with open(GENE_MAPPING_FILE, "rb") as f: + gene_id_mapping = pickle.load(f) + return index, gene_id_mapping + + gene_ids, vectors = zip(*embeddings.items()) + vectors = np.vstack(vectors).astype("float32") + + index = faiss.IndexFlatL2(vectors.shape[1]) + index.add(vectors) + + gene_id_mapping = {i: genes_df.loc[genes_df["node_index"] == gene_id, ["node_name", "node_id"]].values[0] + for i, gene_id in enumerate(gene_ids)} + + faiss.write_index(index, INDEX_FILE) + with open(GENE_MAPPING_FILE, "wb") as f: + pickle.dump(gene_id_mapping, f) + + print(f"FAISS index built and saved with {index.ntotal} vectors.") + return index, gene_id_mapping + + +def find_closest_gene(description, index, gene_id_mapping): + """Find the closest matching gene using FAISS.""" + if index is None or gene_id_mapping is None: + print("FAISS index not built.") + return None + + print("🔹 Embedding description with OpenAI API...") + query_embedding = get_openai_embedding(description).astype("float32") + + print("🔹 Performing FAISS vector search...") + distances, indices = index.search(query_embedding.reshape(1, -1), k=1) + + best_match_idx = indices[0][0] + best_match_score = distances[0][0] + best_match_gene, ncbi_id = gene_id_mapping[best_match_idx] + + print(f"Best match found: {best_match_gene} (NCBI ID: {ncbi_id}, Score: {best_match_score:.4f})") + + return {"Gene Name": best_match_gene, "NCBI ID": ncbi_id, "Score": best_match_score} + + + + +# Extract genes +genes_df = extract_genes_from_go() + +# Compute or load embeddings +embeddings = compute_embeddings_for_genes(genes_df) + +# Build or load FAISS index +index, gene_id_mapping = build_faiss_index(genes_df, embeddings) + diff --git a/docs/notebooks/talk2biomodels/extract_all_genes.py b/docs/notebooks/talk2biomodels/extract_all_genes.py new file mode 100644 index 00000000..bb082b19 --- /dev/null +++ b/docs/notebooks/talk2biomodels/extract_all_genes.py @@ -0,0 +1,67 @@ +import os +import numpy as np +import pandas as pd +from aiagents4pharma.talk2knowledgegraphs.datasets.primekg import PrimeKG + +def extract_genes_from_go(go_keywords=['drug discovery', 'immune system process', 'inflammatory response']): + """ + Extract genes/proteins that are associated with GO terms related to immune and inflammation processes. + + Parameters: + - go_keywords (list): List of keywords to match GO terms (default: ["immune", "inflammation"]). + + Returns: + - genes_df (pd.DataFrame): DataFrame containing genes/proteins linked to the selected GO terms. + """ + + # Load PrimeKG dataset + primekg_data = PrimeKG(local_dir="../../../../data/primekg/") + primekg_data.load_data() + + # Get all nodes and edges + primekg_nodes = primekg_data.get_nodes() + primekg_edges = primekg_data.get_edges() + + # 🔹 STEP 1: Extract Relevant GO Terms + go_query = "|".join(go_keywords) # Create OR search pattern + go_terms_df = primekg_nodes[ + (primekg_nodes["node_type"].isin(["biological_process", "molecular_function", "cellular_component"])) & + (primekg_nodes["node_name"].str.contains(go_query, case=False, na=False)) + ] + + if go_terms_df.empty: + print(f"No GO terms matching {go_keywords} found in PrimeKG!") + return None + + go_term_ids = go_terms_df.index.values + print(f"Found {len(go_term_ids)} GO terms related to {go_keywords}.") + + # 🔹 STEP 2: Extract Gene-GO Relationships + gene_go_edges_df = primekg_edges[ + ((primekg_edges.head_index.isin(go_term_ids)) & (primekg_edges.tail_type == "gene/protein")) | + ((primekg_edges.tail_index.isin(go_term_ids)) & (primekg_edges.head_type == "gene/protein")) + ] + + if gene_go_edges_df.empty: + print(f"No gene-GO relationships found for {go_keywords}!") + return None + + gene_ids = np.unique( + np.concatenate([ + gene_go_edges_df[gene_go_edges_df.head_type == "gene/protein"].head_index.unique(), + gene_go_edges_df[gene_go_edges_df.tail_type == "gene/protein"].tail_index.unique() + ]) + ) + + print(f"Found {len(gene_ids)} genes/proteins linked to immune/inflammation GO terms.") + + # 🔹 STEP 3: Extract the Gene Nodes + genes_df = primekg_nodes[primekg_nodes.index.isin(gene_ids)] + genes_df.to_csv('genes_df.csv') + + print(f"Extracted {len(genes_df)} gene/protein nodes from PrimeKG based on immune/inflammation GO terms.") + + return genes_df + + +genes_df = extract_genes_from_go() \ No newline at end of file diff --git a/docs/notebooks/talk2biomodels/extract_disease_subgraph.py b/docs/notebooks/talk2biomodels/extract_disease_subgraph.py new file mode 100644 index 00000000..5924f505 --- /dev/null +++ b/docs/notebooks/talk2biomodels/extract_disease_subgraph.py @@ -0,0 +1,97 @@ +import os +import numpy as np +import pandas as pd +import networkx as nx +import pickle +from tqdm import tqdm +from aiagents4pharma.talk2knowledgegraphs.datasets.primekg import PrimeKG + +def extract_disease_subgraph(disease_names=["crohn", "inflammatory bowel disease", "ulcerative colitis"]): + """ + Extracts the subgraph of genes, GO terms, and ontologies related to given diseases. + + Parameters: + - disease_names (list): List of disease names (default includes Crohn's, IBD, and Ulcerative Colitis). + + Returns: + - subgraph_nodes_df (pd.DataFrame): DataFrame containing the nodes in the extracted subgraph. + - subgraph_edges_df (pd.DataFrame): DataFrame containing the edges in the extracted subgraph. + """ + + # Load PrimeKG dataset + primekg_data = PrimeKG(local_dir="../../../../data/primekg/") + primekg_data.load_data() + + # Get all nodes and edges + primekg_nodes = primekg_data.get_nodes() + primekg_edges = primekg_data.get_edges() + + # 🔹 STEP 1: Extract Disease Nodes + disease_names = [d.lower() for d in disease_names] + disease_query = "|".join(disease_names) # Combine all disease names for OR search + disease_nodes_df = primekg_nodes[ + (primekg_nodes["node_type"] == "disease") & + (primekg_nodes["node_name"].str.contains(disease_query, case=False, na=False)) + ] + + if disease_nodes_df.empty: + print(f"⚠️ No matching disease found in PrimeKG!") + return None, None + + disease_ids = disease_nodes_df.index.values + print(f"✅ Found {len(disease_ids)} disease nodes for '{disease_names}'.") + + # 🔹 STEP 2: Extract Disease-Gene Relationships + disease_gene_edges_df = primekg_edges[ + ((primekg_edges.head_index.isin(disease_ids)) & (primekg_edges.tail_type == "gene/protein")) | + ((primekg_edges.tail_index.isin(disease_ids)) & (primekg_edges.head_type == "gene/protein")) + ] + + gene_ids = np.unique( + np.concatenate([ + disease_gene_edges_df[disease_gene_edges_df.head_type == "gene/protein"].head_index.unique(), + disease_gene_edges_df[disease_gene_edges_df.tail_type == "gene/protein"].tail_index.unique() + ]) + ) + print(f"✅ Found {len(gene_ids)} genes/proteins related to '{disease_names}'.") + + # 🔹 STEP 3: Extract GO Terms (biological_process, molecular_function, cellular_component) + go_terms_df = primekg_nodes[ + primekg_nodes["node_type"].isin(["biological_process", "molecular_function", "cellular_component"]) + ] + go_term_ids = go_terms_df.index.values + + # 🔹 STEP 4: Extract Ontologies (SNOMEDCT, BTO, FMA, Anatomy) + ontology_nodes = primekg_nodes[ + primekg_nodes["node_type"].isin(["SNOMEDCT", "BTO", "FMA", "anatomy"]) + ] + ontology_ids = ontology_nodes.index.values + + # 🔹 STEP 5: Extract Subgraph Edges (Gene → GO Terms → Ontologies) + subgraph_edges_df = primekg_edges[ + ((primekg_edges.head_index.isin(gene_ids)) & (primekg_edges.tail_index.isin(go_term_ids))) | + ((primekg_edges.tail_index.isin(gene_ids)) & (primekg_edges.head_index.isin(go_term_ids))) | + ((primekg_edges.head_index.isin(go_term_ids)) & (primekg_edges.tail_index.isin(ontology_ids))) | + ((primekg_edges.tail_index.isin(go_term_ids)) & (primekg_edges.head_index.isin(ontology_ids))) | + ((primekg_edges.head_index.isin(gene_ids)) & (primekg_edges.tail_index.isin(ontology_ids))) | + ((primekg_edges.tail_index.isin(gene_ids)) & (primekg_edges.head_index.isin(ontology_ids))) + ] + + # 🔹 STEP 6: Extract All Related Nodes + subgraph_node_ids = np.unique( + np.hstack([subgraph_edges_df.head_index.unique(), subgraph_edges_df.tail_index.unique()]) + ) + subgraph_nodes_df = primekg_nodes[primekg_nodes.index.isin(subgraph_node_ids)] + + print(f"✅ Final subgraph contains {len(subgraph_nodes_df)} nodes and {len(subgraph_edges_df)} edges.") + + return subgraph_nodes_df, subgraph_edges_df + + +# Example Usage +subgraph_nodes, subgraph_edges = extract_disease_subgraph( + ["Crohn's Disease", "Inflammatory Bowel Disease", "Ulcerative Colitis"] +) + +# To extract for another set of diseases, simply change the list: +# subgraph_nodes, subgraph_edges = extract_disease_subgraph(["Lung Cancer", "Breast Cancer"]) diff --git a/docs/notebooks/talk2biomodels/extract_relevant_GOTerms.py b/docs/notebooks/talk2biomodels/extract_relevant_GOTerms.py new file mode 100644 index 00000000..8f77b9fe --- /dev/null +++ b/docs/notebooks/talk2biomodels/extract_relevant_GOTerms.py @@ -0,0 +1,63 @@ +import os +import fitz # PyMuPDF +import openai +from dotenv import load_dotenv + +# Load API key from .env file +load_dotenv() +OPENAI_API_KEY = os.getenv("OPENAI_API_KEY") + +# Function to extract text from a PDF +def extract_text_from_pdf(pdf_path): + text = "" + with fitz.open(pdf_path) as doc: + for page_num in range(len(doc)): + page = doc.load_page(page_num) + text += page.get_text() + return text + +def get_disease_names_from_text(text): + """Uses GPT-4o Mini API to extract disease names from text.""" + if not OPENAI_API_KEY: + raise ValueError("Missing OpenAI API key. Ensure it's set in the .env file.") + + client = openai.OpenAI(api_key=OPENAI_API_KEY) + + prompt = f""" + The following text is extracted from a scientific paper. Identify the 3 high level Gene Ontologies related the text form below terms: + e.g: Metabolism, immune system process, plasma membrane, mitochondria, etc. + + + Extracted Paper Text: + {text} + + **Return only keywords as a comma-separated list (no explanations).** + """ + + response = client.chat.completions.create( + model="gpt-4o-mini", + messages=[{"role": "user", "content": prompt}] + ) + + extracted_diseases = response.choices[0].message.content.split(", ") + return extracted_diseases if extracted_diseases else ["No known diseases found"] + +def extract_diseases_from_pdf(pdf_path): + """Main function to extract disease names from a PDF.""" + text = extract_text_from_pdf(pdf_path) + if not text: + return "No text found in PDF." + + disease_names = get_disease_names_from_text(text) + return disease_names + +def main(): + # path to pdf + pdf = 'psp201364a.pdf' # Replace with the path to PDF, may be better method for this + + diseases = extract_diseases_from_pdf(pdf) + + print(diseases) + +if __name__ == "__main__": + main() \ No newline at end of file diff --git a/docs/notebooks/talk2biomodels/faiss_index.bin b/docs/notebooks/talk2biomodels/faiss_index.bin new file mode 100644 index 00000000..900b8c70 Binary files /dev/null and b/docs/notebooks/talk2biomodels/faiss_index.bin differ diff --git a/docs/notebooks/talk2biomodels/gene_embeddings.pkl b/docs/notebooks/talk2biomodels/gene_embeddings.pkl new file mode 100644 index 00000000..6f2bd4a5 Binary files /dev/null and b/docs/notebooks/talk2biomodels/gene_embeddings.pkl differ diff --git a/docs/notebooks/talk2biomodels/gene_id_mapping.pkl b/docs/notebooks/talk2biomodels/gene_id_mapping.pkl new file mode 100644 index 00000000..c6f3753c Binary files /dev/null and b/docs/notebooks/talk2biomodels/gene_id_mapping.pkl differ diff --git a/docs/notebooks/talk2biomodels/genes_df.csv b/docs/notebooks/talk2biomodels/genes_df.csv new file mode 100644 index 00000000..fe6724af --- /dev/null +++ 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+59869,59869,MIR920,NCBI,100126320,gene/protein +59876,59876,MIR3909,NCBI,100500826,gene/protein +59879,59879,MIR6869,NCBI,102465524,gene/protein +59926,59926,ACOD1,NCBI,730249,gene/protein +59967,59967,IGKV3D-20,NCBI,28874,gene/protein +59970,59970,IGKV2D-30,NCBI,28881,gene/protein +59981,59981,IGKV2-29,NCBI,28920,gene/protein +59982,59982,IGKV2-28,NCBI,28921,gene/protein +59987,59987,IGKV1-12,NCBI,28940,gene/protein +60121,60121,PTH2,NCBI,113091,gene/protein +60314,60314,DUOXA1,NCBI,90527,gene/protein +60383,60383,CEACAM20,NCBI,125931,gene/protein diff --git a/docs/notebooks/talk2biomodels/get_descriptions_fromPdf.py b/docs/notebooks/talk2biomodels/get_descriptions_fromPdf.py new file mode 100644 index 00000000..b3b3b0fb --- /dev/null +++ b/docs/notebooks/talk2biomodels/get_descriptions_fromPdf.py @@ -0,0 +1,68 @@ +import fitz # PyMuPDF +import openai +import json +from tqdm import tqdm +import pandas as pd +import sys +import os +from dotenv import load_dotenv + +# Function to extract text from a PDF +def extract_text_from_pdf(pdf_path): + text = "" + with fitz.open(pdf_path) as doc: + for page_num in range(len(doc)): + page = doc.load_page(page_num) + text += page.get_text() + return text + +# Function to query the GPT API +def query_gpt(prompt, api_key): + openai.api_key = api_key + response = openai.ChatCompletion.create( + model="gpt-4o-mini", + messages=[ + {"role": "system", "content": "You are a helpful assistant."}, + {"role": "user", "content": prompt} + ] + ) + try: + res = response['choices'][0]['message']['content'].strip() + res = json.loads(res) + return res['description'] + except Exception as e: + return 'No description found' + +# Main function +def main(pdf_path,names,output_file='descriptions_output.json'): + # Extract text from the PDF + paper_text = extract_text_from_pdf(pdf_path) + load_dotenv() + api_key = os.getenv('OPENAI_API_KEY') + descs = {} + # Loop over each name and query the GPT API + for name in tqdm(names, desc='Extracting descriptions'): + prompt = ( + f"JUST ANSWER WITH THE DESCRIPTION WE ARE LOOKING FOR. " + f"Extract the description of {name} species from this paper:\n\n" + f"{paper_text}\n\n" + f"DO NOT PUT ANY MORE INFO THAN THE SPECIES DESCRIPTION. " + f"Let the response be JSON with key 'description'." + ) + description = query_gpt(prompt, api_key) + descs[name] = description + print(f"Species: {name}") + print(f"Description: {description}") + #write to file + with open(output_file, 'w') as f: + json.dump(descs, f) + + +if __name__ == '__main__': + args = sys.argv[1:] + names_path = 'model537_mapping.xlsx' + names_df = pd.read_excel(names_path) + names_df.columns = names_df.columns.str.strip() + names_df = names_df[names_df['Species Name'].notnull()] + names = names_df['Species Name'].tolist() + main(args[0],names) diff --git a/docs/notebooks/talk2biomodels/psp201364a.pdf b/docs/notebooks/talk2biomodels/psp201364a.pdf new file mode 100644 index 00000000..ccd565ff Binary files /dev/null and b/docs/notebooks/talk2biomodels/psp201364a.pdf differ diff --git a/docs/notebooks/talk2biomodels/psp201364a.pdf:Zone.Identifier b/docs/notebooks/talk2biomodels/psp201364a.pdf:Zone.Identifier new file mode 100644 index 00000000..759a646f --- /dev/null +++ b/docs/notebooks/talk2biomodels/psp201364a.pdf:Zone.Identifier @@ -0,0 +1,4 @@ +[ZoneTransfer] +ZoneId=3 +ReferrerUrl=https://pmc.ncbi.nlm.nih.gov/articles/PMC3910013/pdf/psp201364a.pdf +HostUrl=https://pmc.ncbi.nlm.nih.gov/articles/PMC3910013/pdf/psp201364a.pdf diff --git a/docs/notebooks/talk2biomodels/species_gene_matches.csv b/docs/notebooks/talk2biomodels/species_gene_matches.csv new file mode 100644 index 00000000..c41d908d --- /dev/null +++ b/docs/notebooks/talk2biomodels/species_gene_matches.csv @@ -0,0 +1,45 @@ +species_name,ncbi_node_id +Ab_R,3570 +Ab_sR_IL6{gut},3570 +Ab_sR_IL6{liver},3570 +Ab_sR_IL6{serum},3570 +Ab_sR{gut},3570 +Ab_sR{liver},3569 +Ab_sR{serum},6288 +Ab{gut},171389 +Ab{liver},25 +Ab{peripheral},25 +Ab{serum},3570 +CRP (% of baseline),1401 +CRP Suppression (%),1401 +CRPExtracellular,1401 +CRP{liver},1401 +CRP{serum},1401 +geneProduct,3320 +gp130{gut},3572 +gp130{liver},3570 +IL6{gut},3569 +IL6{liver},3569 +IL6{serum},3569 +pSTAT3{gut},6774 +pSTAT3{liver},6774 +R,6194 +R_IL6,3570 +R_IL6_gp130{gut},3570 +R_IL6_gp130{liver},3569 +Reactive{gut},1401 +Reactive{liver},1401 +sgp130{gut},3570 +sgp130{liver},3570 +sgp130{serum},3570 +sR_IL6_sgp130{gut},3570 +sR_IL6_sgp130{liver},3570 +sR_IL6_sgp130{serum},3570 +sR_IL6{gut},3570 +sR_IL6{liver},3570 +sR_IL6{serum},3570 +sR{gut},3570 +sR{liver},1401 +sR{serum},3570 +STAT3{gut},6774 +STAT3{liver},6774 diff --git a/docs/notebooks/talk2biomodels/subgraph_nodes.csv b/docs/notebooks/talk2biomodels/subgraph_nodes.csv new file mode 100644 index 00000000..f4ce7f6b --- /dev/null +++ b/docs/notebooks/talk2biomodels/subgraph_nodes.csv @@ -0,0 +1,2424 @@ +,node_index,node_name,node_source,node_id,node_type +144,144,SMAD3,NCBI,4088,gene/protein +179,179,IL10RB,NCBI,3588,gene/protein +192,192,GNA12,NCBI,2768,gene/protein +279,279,HNF4A,NCBI,3172,gene/protein +417,417,VCAM1,NCBI,7412,gene/protein +625,625,IL7R,NCBI,3575,gene/protein +657,657,DEFA6,NCBI,1671,gene/protein +729,729,STAT3,NCBI,6774,gene/protein +772,772,RELA,NCBI,5970,gene/protein +989,989,PPARG,NCBI,5468,gene/protein +1004,1004,IL1B,NCBI,3553,gene/protein +1122,1122,PPARA,NCBI,5465,gene/protein +1299,1299,IL10RA,NCBI,3587,gene/protein +1480,1480,ADIPOQ,NCBI,9370,gene/protein +1567,1567,IL6,NCBI,3569,gene/protein +1618,1618,JAK2,NCBI,3717,gene/protein +1654,1654,IL1R2,NCBI,7850,gene/protein +1777,1777,HERC2,NCBI,8924,gene/protein +1990,1990,FCGR2A,NCBI,2212,gene/protein +2012,2012,CXCR1,NCBI,3577,gene/protein +2057,2057,FN1,NCBI,2335,gene/protein +2078,2078,SLC26A3,NCBI,1811,gene/protein +2111,2111,LRRK2,NCBI,120892,gene/protein +2139,2139,ARPC2,NCBI,10109,gene/protein +2329,2329,TNF,NCBI,7124,gene/protein +2384,2384,CRP,NCBI,1401,gene/protein +2543,2543,CDH1,NCBI,999,gene/protein +2643,2643,LSP1,NCBI,4046,gene/protein +2712,2712,CASP3,NCBI,836,gene/protein +2749,2749,LAMB1,NCBI,3912,gene/protein +2874,2874,PRDM1,NCBI,639,gene/protein +2889,2889,TGFB1,NCBI,7040,gene/protein 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+11523,11523,LEP,NCBI,3952,gene/protein +11588,11588,IL18RAP,NCBI,8807,gene/protein +12305,12305,NLRP3,NCBI,114548,gene/protein +12663,12663,SLC11A1,NCBI,6556,gene/protein +12740,12740,CCR6,NCBI,1235,gene/protein +12763,12763,ERAP2,NCBI,64167,gene/protein +12816,12816,MUC2,NCBI,4583,gene/protein +13014,13014,PHOX2B,NCBI,8929,gene/protein +13365,13365,CCNY,NCBI,219771,gene/protein +21972,21972,GHRL,NCBI,51738,gene/protein +22105,22105,GPBAR1,NCBI,151306,gene/protein +34623,34623,TNFSF15,NCBI,9966,gene/protein +34776,34776,GPR65,NCBI,8477,gene/protein +34777,34777,MASP2,NCBI,10747,gene/protein +34778,34778,IL23R,NCBI,149233,gene/protein +34779,34779,NKX2-3,NCBI,159296,gene/protein +34780,34780,IRGM,NCBI,345611,gene/protein +34781,34781,IL17REL,NCBI,400935,gene/protein +34814,34814,TAGAP,NCBI,117289,gene/protein +34887,34887,DENND1B,NCBI,163486,gene/protein +34967,34967,IL21,NCBI,59067,gene/protein +39914,39914,regulation of smooth muscle contraction,GO,6940,biological_process +39917,39917,cell migration,GO,16477,biological_process +39918,39918,chemotaxis,GO,6935,biological_process +39920,39920,immune system process,GO,2376,biological_process +39942,39942,lipid metabolic process,GO,6629,biological_process +39945,39945,carbohydrate metabolic process,GO,5975,biological_process +39946,39946,hormone metabolic process,GO,42445,biological_process +39950,39950,import into nucleus,GO,51170,biological_process +39954,39954,intracellular protein transport,GO,6886,biological_process +39967,39967,negative regulation of lipid metabolic process,GO,45833,biological_process +39968,39968,regulation of lipoprotein lipid oxidation,GO,60587,biological_process +39969,39969,basement membrane assembly,GO,70831,biological_process +39991,39991,aging,GO,7568,biological_process +39993,39993,hair cycle process,GO,22405,biological_process +39995,39995,immune response,GO,6955,biological_process +39997,39997,defense response,GO,6952,biological_process +39999,39999,inflammatory response,GO,6954,biological_process +40004,40004,positive regulation of innate immune response,GO,45089,biological_process +40005,40005,positive regulation of cytokine-mediated signaling pathway,GO,1961,biological_process +40007,40007,negative regulation of cytokine-mediated signaling pathway,GO,1960,biological_process +40015,40015,positive regulation of oxidoreductase activity,GO,51353,biological_process +40047,40047,regulation of T-helper cell differentiation,GO,45622,biological_process +40052,40052,regulation of complement activation,GO,30449,biological_process +40058,40058,negative regulation of inflammatory response,GO,50728,biological_process +40062,40062,negative regulation of phagocytosis,GO,50765,biological_process +40074,40074,negative regulation of gene expression,GO,10629,biological_process +40079,40079,anatomical structure development,GO,48856,biological_process +40080,40080,post-embryonic development,GO,9791,biological_process +40081,40081,extracellular matrix organization,GO,30198,biological_process +40082,40082,neuron projection development,GO,31175,biological_process +40085,40085,maternal process involved in female pregnancy,GO,60135,biological_process +40092,40092,phosphate-containing compound metabolic process,GO,6796,biological_process +40124,40124,fatty acid metabolic process,GO,6631,biological_process +40136,40136,xenobiotic metabolic process,GO,6805,biological_process +40200,40200,"positive regulation of CD4-positive, alpha-beta T cell activation",GO,2000516,biological_process +40201,40201,positive regulation of alpha-beta T cell proliferation,GO,46641,biological_process +40210,40210,positive regulation of ion transport,GO,43270,biological_process +40214,40214,positive regulation of inflammatory response,GO,50729,biological_process +40225,40225,positive regulation of cell population proliferation,GO,8284,biological_process +40237,40237,positive regulation of cell differentiation,GO,45597,biological_process +40247,40247,positive regulation of cell migration,GO,30335,biological_process +40257,40257,positive regulation of protein-containing complex assembly,GO,31334,biological_process +40264,40264,positive regulation of epidermal growth factor receptor signaling pathway,GO,45742,biological_process +40269,40269,regulation of multicellular organism growth,GO,40014,biological_process +40270,40270,positive regulation of developmental growth,GO,48639,biological_process +40281,40281,positive regulation of protein secretion,GO,50714,biological_process +40283,40283,regulation of branching morphogenesis of a nerve,GO,2000172,biological_process +40301,40301,positive regulation of epithelial cell proliferation,GO,50679,biological_process +40315,40315,positive regulation of immunoglobulin production,GO,2639,biological_process +40316,40316,regulation of isotype switching,GO,45191,biological_process +40318,40318,positive regulation of B cell activation,GO,50871,biological_process +40343,40343,positive regulation of canonical Wnt signaling pathway,GO,90263,biological_process +40359,40359,positive regulation of insulin receptor signaling pathway,GO,46628,biological_process +40373,40373,positive regulation of neuron differentiation,GO,45666,biological_process +40378,40378,regulation of cytokine production,GO,1817,biological_process +40379,40379,positive regulation of gene expression,GO,10628,biological_process +40387,40387,oxalate transport,GO,19532,biological_process +40397,40397,regulation of leukocyte mediated cytotoxicity,GO,1910,biological_process +40401,40401,positive regulation of cytokine production involved in immune response,GO,2720,biological_process +40402,40402,regulation of dendritic cell cytokine production,GO,2730,biological_process +40405,40405,cell differentiation,GO,30154,biological_process +40411,40411,chromatin organization,GO,6325,biological_process +40412,40412,Wnt signaling pathway,GO,16055,biological_process +40415,40415,cell division,GO,51301,biological_process +40418,40418,positive regulation of actin filament polymerization,GO,30838,biological_process +40423,40423,cell maturation,GO,48469,biological_process +40438,40438,cell-cell signaling,GO,7267,biological_process +40439,40439,G protein-coupled receptor signaling pathway,GO,7186,biological_process +40445,40445,DNA methylation,GO,6306,biological_process +40451,40451,cell population proliferation,GO,8283,biological_process +40454,40454,cell fate commitment,GO,45165,biological_process +40462,40462,cell chemotaxis,GO,60326,biological_process +40463,40463,positive chemotaxis,GO,50918,biological_process +40469,40469,epithelial cell differentiation,GO,30855,biological_process +40494,40494,amine metabolic process,GO,9308,biological_process +40548,40548,tissue development,GO,9888,biological_process +40549,40549,animal organ morphogenesis,GO,9887,biological_process +40558,40558,extracellular matrix assembly,GO,85029,biological_process +40561,40561,gland morphogenesis,GO,22612,biological_process +40578,40578,developmental growth,GO,48589,biological_process +40583,40583,blood vessel development,GO,1568,biological_process +40588,40588,anatomical structure morphogenesis,GO,9653,biological_process +40605,40605,hydrogen peroxide catabolic process,GO,42744,biological_process +40608,40608,peptide catabolic process,GO,43171,biological_process +40611,40611,regulation of epithelial cell proliferation,GO,50678,biological_process +40612,40612,negative regulation of cell population proliferation,GO,8285,biological_process +40621,40621,regulation of cellular ketone metabolic process,GO,10565,biological_process +40628,40628,regulation of lipid metabolic process,GO,19216,biological_process +40633,40633,regulation of steroid biosynthetic process,GO,50810,biological_process +40658,40658,negative regulation of epithelial cell differentiation,GO,30857,biological_process +40679,40679,cell morphogenesis,GO,902,biological_process +40691,40691,innate immune response,GO,45087,biological_process +40692,40692,complement activation,GO,6956,biological_process +40694,40694,defense response to fungus,GO,50832,biological_process +40696,40696,defense response to bacterium,GO,42742,biological_process +40700,40700,humoral immune response,GO,6959,biological_process +40703,40703,cellular response to stress,GO,33554,biological_process +40706,40706,defense response to virus,GO,51607,biological_process +40715,40715,positive regulation of cellular biosynthetic process,GO,31328,biological_process +40716,40716,positive regulation of nitrogen compound metabolic process,GO,51173,biological_process +40728,40728,positive regulation of lipid catabolic process,GO,50996,biological_process +40731,40731,positive regulation of cellular respiration,GO,1901857,biological_process +40736,40736,positive regulation of lipid biosynthetic process,GO,46889,biological_process +40738,40738,positive regulation of fatty acid metabolic process,GO,45923,biological_process +40751,40751,response to salt stress,GO,9651,biological_process +40753,40753,hyperosmotic response,GO,6972,biological_process +40767,40767,positive regulation of protein binding,GO,32092,biological_process +40792,40792,cholesterol metabolic process,GO,8203,biological_process +40807,40807,regulation of cell migration,GO,30334,biological_process +40827,40827,salivary gland morphogenesis,GO,7435,biological_process +40873,40873,response to progesterone,GO,32570,biological_process +40877,40877,cellular response to organic cyclic compound,GO,71407,biological_process +40878,40878,cellular response to organonitrogen compound,GO,71417,biological_process +40892,40892,cellular response to organic substance,GO,71310,biological_process +40916,40916,negative regulation of lipid catabolic process,GO,50995,biological_process +40924,40924,response to glucocorticoid,GO,51384,biological_process +40925,40925,response to organic cyclic compound,GO,14070,biological_process +40930,40930,response to lipid,GO,33993,biological_process +40937,40937,positive regulation of programmed cell death,GO,43068,biological_process +40941,40941,negative regulation of hydrogen peroxide-induced cell death,GO,1903206,biological_process +40962,40962,regulation of type 2 immune response,GO,2828,biological_process +40967,40967,regulation of adaptive immune response,GO,2819,biological_process +40975,40975,anion transport,GO,6820,biological_process +40976,40976,regulation of membrane potential,GO,42391,biological_process +40980,40980,negative regulation of platelet-derived growth factor receptor signaling pathway,GO,10642,biological_process +40983,40983,cellular response to amino acid stimulus,GO,71230,biological_process +40996,40996,negative regulation of cell differentiation,GO,45596,biological_process +40998,40998,regulation of endocytosis,GO,30100,biological_process +41003,41003,regulation of phagocytosis,GO,50764,biological_process +41023,41023,S-adenosylmethionine metabolic process,GO,46500,biological_process +41047,41047,protein transport,GO,15031,biological_process +41059,41059,receptor-mediated endocytosis,GO,6898,biological_process +41065,41065,transmembrane transport,GO,55085,biological_process +41078,41078,negative regulation of ATPase activity,GO,32780,biological_process +41084,41084,Golgi organization,GO,7030,biological_process +41100,41100,membrane organization,GO,61024,biological_process +41109,41109,cortical actin cytoskeleton organization,GO,30866,biological_process +41129,41129,peptide cross-linking,GO,18149,biological_process +41133,41133,protein phosphorylation,GO,6468,biological_process +41157,41157,positive regulation of osteoclast differentiation,GO,45672,biological_process +41163,41163,positive regulation of cardiac muscle cell differentiation,GO,2000727,biological_process +41167,41167,positive regulation of chondrocyte differentiation,GO,32332,biological_process +41181,41181,regulation of neurogenesis,GO,50767,biological_process +41188,41188,hematopoietic progenitor cell differentiation,GO,2244,biological_process +41259,41259,regulation of dendritic spine morphogenesis,GO,61001,biological_process +41289,41289,regulation of DNA binding,GO,51101,biological_process +41292,41292,negative regulation of T cell apoptotic process,GO,70233,biological_process +41298,41298,regulation of immune response,GO,50776,biological_process +41304,41304,negative regulation of cell migration,GO,30336,biological_process +41315,41315,regulation of natural killer cell mediated cytotoxicity,GO,42269,biological_process +41318,41318,negative regulation of T cell mediated immunity,GO,2710,biological_process +41320,41320,cellular response to DNA damage stimulus,GO,6974,biological_process +41325,41325,regulation of transcription by RNA polymerase II,GO,6357,biological_process +41362,41362,double-strand break repair,GO,6302,biological_process +41430,41430,regulation of transforming growth factor beta receptor signaling pathway,GO,17015,biological_process +41433,41433,regulation of SMAD protein signal transduction,GO,60390,biological_process +41434,41434,positive regulation of protein phosphorylation,GO,1934,biological_process +41480,41480,regulation of cell shape,GO,8360,biological_process +41481,41481,regulation of canonical Wnt signaling pathway,GO,60828,biological_process +41524,41524,regulation of gene expression,GO,10468,biological_process +41537,41537,positive regulation of protein-containing complex disassembly,GO,43243,biological_process +41607,41607,positive regulation of protein transport,GO,51222,biological_process +41621,41621,positive regulation of dopamine receptor signaling pathway,GO,60161,biological_process +41628,41628,negative regulation of protein phosphorylation,GO,1933,biological_process +41638,41638,cellular protein metabolic process,GO,44267,biological_process +41670,41670,glucose metabolic process,GO,6006,biological_process +41684,41684,lysosome organization,GO,7040,biological_process +41707,41707,regulation of gastrulation,GO,10470,biological_process +41716,41716,regulation of reactive oxygen species metabolic process,GO,2000377,biological_process +41720,41720,regulation of fatty acid metabolic process,GO,19217,biological_process +41751,41751,phosphorylation,GO,16310,biological_process +41780,41780,negative regulation of neuron differentiation,GO,45665,biological_process +41845,41845,regulation of nitric oxide biosynthetic process,GO,45428,biological_process +41852,41852,regulation of gluconeogenesis,GO,6111,biological_process +41857,41857,regulation of fatty acid biosynthetic process,GO,42304,biological_process +41894,41894,positive regulation of reactive oxygen species biosynthetic process,GO,1903428,biological_process +41907,41907,positive regulation of cellular protein metabolic process,GO,32270,biological_process +41918,41918,regulation of bile acid biosynthetic process,GO,70857,biological_process +41968,41968,immune response-regulating cell surface receptor signaling pathway,GO,2768,biological_process +41981,41981,hormone-mediated signaling pathway,GO,9755,biological_process +41990,41990,positive regulation of protein ubiquitination,GO,31398,biological_process +41996,41996,glycolate metabolic process,GO,9441,biological_process +42011,42011,negative regulation of protein secretion,GO,50709,biological_process +42013,42013,regulation of transmission of nerve impulse,GO,51969,biological_process +42025,42025,modulation of chemical synaptic transmission,GO,50804,biological_process +42036,42036,cellular response to drug,GO,35690,biological_process +42063,42063,cellular response to hormone stimulus,GO,32870,biological_process +42073,42073,response to cobalamin,GO,33590,biological_process +42088,42088,response to estradiol,GO,32355,biological_process +42100,42100,cellular response to alkaloid,GO,71312,biological_process +42104,42104,response to vitamin E,GO,33197,biological_process +42113,42113,response to cAMP,GO,51591,biological_process +42119,42119,response to folic acid,GO,51593,biological_process +42120,42120,response to vitamin B2,GO,33274,biological_process +42127,42127,cellular response to fatty acid,GO,71398,biological_process +42134,42134,response to cocaine,GO,42220,biological_process +42151,42151,xenobiotic transport,GO,42908,biological_process +42157,42157,transepithelial transport,GO,70633,biological_process +42161,42161,quaternary ammonium group transport,GO,15697,biological_process +42162,42162,terpenoid transport,GO,46865,biological_process +42164,42164,negative regulation of stem cell differentiation,GO,2000737,biological_process +42173,42173,negative regulation of BMP signaling pathway,GO,30514,biological_process +42179,42179,negative regulation of epithelial cell proliferation,GO,50680,biological_process +42183,42183,negative regulation of cell-cell adhesion,GO,22408,biological_process +42186,42186,negative regulation of hormone secretion,GO,46888,biological_process +42188,42188,negative regulation of insulin receptor signaling pathway,GO,46627,biological_process +42193,42193,negative regulation of G protein-coupled receptor signaling pathway,GO,45744,biological_process +42210,42210,negative regulation of epidermal growth factor receptor signaling pathway,GO,42059,biological_process +42222,42222,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,GO,1902042,biological_process +42240,42240,regulation of macroautophagy,GO,16241,biological_process +42241,42241,regulation of protein-containing complex assembly,GO,43254,biological_process +42244,42244,regulation of postsynapse organization,GO,99175,biological_process +42246,42246,methylation,GO,32259,biological_process +42258,42258,negative regulation of extrinsic apoptotic signaling pathway,GO,2001237,biological_process +42266,42266,negative regulation of apoptotic signaling pathway,GO,2001234,biological_process +42276,42276,regulation of natural killer cell proliferation,GO,32817,biological_process +42282,42282,response to antibiotic,GO,46677,biological_process +42283,42283,response to amino acid,GO,43200,biological_process +42287,42287,response to hormone,GO,9725,biological_process +42295,42295,bile acid metabolic process,GO,8206,biological_process +42296,42296,response to drug,GO,42493,biological_process +42297,42297,response to organic substance,GO,10033,biological_process +42321,42321,carboxylic acid transmembrane transport,GO,1905039,biological_process +42328,42328,regulation of cell population proliferation,GO,42127,biological_process +42335,42335,positive regulation of acute inflammatory response,GO,2675,biological_process +42337,42337,negative regulation of acute inflammatory response,GO,2674,biological_process +42340,42340,regulation of B cell differentiation,GO,45577,biological_process +42351,42351,"positive regulation of transcription, DNA-templated",GO,45893,biological_process +42370,42370,cellular protein localization,GO,34613,biological_process +42378,42378,organic cation transport,GO,15695,biological_process +42383,42383,signal transduction,GO,7165,biological_process +42385,42385,response to endoplasmic reticulum stress,GO,34976,biological_process +42386,42386,regulation of blood pressure,GO,8217,biological_process +42408,42408,positive regulation of cytosolic calcium ion concentration,GO,7204,biological_process +42417,42417,negative regulation of protein targeting to mitochondrion,GO,1903215,biological_process +42420,42420,negative regulation of intracellular protein transport,GO,90317,biological_process +42421,42421,regulation of protein import into nucleus,GO,42306,biological_process +42425,42425,long-chain fatty acid transport,GO,15909,biological_process +42428,42428,amino acid import across plasma membrane,GO,89718,biological_process +42604,42604,B cell differentiation,GO,30183,biological_process +42605,42605,morphogenesis of a branching structure,GO,1763,biological_process +42627,42627,positive regulation of signal transduction,GO,9967,biological_process +42630,42630,regulation of fatty acid transport,GO,2000191,biological_process +42659,42659,response to vitamin A,GO,33189,biological_process +42668,42668,response to lipopolysaccharide,GO,32496,biological_process +42680,42680,protein processing,GO,16485,biological_process +42713,42713,sphingolipid metabolic process,GO,6665,biological_process +42745,42745,regulation of macrophage chemotaxis,GO,10758,biological_process +42746,42746,positive regulation of leukocyte chemotaxis,GO,2690,biological_process +42774,42774,negative regulation of neuron projection development,GO,10977,biological_process +42776,42776,negative regulation of neurogenesis,GO,50768,biological_process +42809,42809,GTP metabolic process,GO,46039,biological_process +42844,42844,negative regulation of transcription by RNA polymerase II,GO,122,biological_process +42846,42846,negative regulation of insulin secretion,GO,46676,biological_process +42847,42847,regulation of insulin secretion involved in cellular response to glucose stimulus,GO,61178,biological_process +42876,42876,regulation of response to wounding,GO,1903034,biological_process +42880,42880,cellular homeostasis,GO,19725,biological_process +42887,42887,receptor internalization,GO,31623,biological_process +42928,42928,regulation of binding,GO,51098,biological_process +42937,42937,viral entry into host cell,GO,46718,biological_process +42939,42939,endocytosis,GO,6897,biological_process +42955,42955,negative regulation of mitotic cell cycle,GO,45930,biological_process +42957,42957,positive regulation of mitotic cell cycle,GO,45931,biological_process +42999,42999,regulation of glucose metabolic process,GO,10906,biological_process +43037,43037,negative regulation of T cell receptor signaling pathway,GO,50860,biological_process +43040,43040,response to toxic substance,GO,9636,biological_process +43054,43054,response to nicotine,GO,35094,biological_process +43056,43056,cellular response to nutrient levels,GO,31669,biological_process +43057,43057,response to nutrient,GO,7584,biological_process +43061,43061,response to food,GO,32094,biological_process +43079,43079,cell activation,GO,1775,biological_process +43083,43083,activation of innate immune response,GO,2218,biological_process +43084,43084,leukocyte migration,GO,50900,biological_process +43085,43085,activation of immune response,GO,2253,biological_process +43086,43086,respiratory burst,GO,45730,biological_process +43091,43091,protein acetylation,GO,6473,biological_process +43117,43117,lipoprotein metabolic process,GO,42157,biological_process +43120,43120,autophagy,GO,6914,biological_process +43148,43148,negative regulation of cytokine production,GO,1818,biological_process +43149,43149,positive regulation of cytokine production,GO,1819,biological_process +43151,43151,"negative regulation of transcription, DNA-templated",GO,45892,biological_process +43153,43153,"negative regulation of gene expression, epigenetic",GO,45814,biological_process +43163,43163,regulation of apoptotic process,GO,42981,biological_process +43173,43173,ion transport,GO,6811,biological_process +43196,43196,regulation of cholesterol metabolic process,GO,90181,biological_process +43228,43228,reactive oxygen species biosynthetic process,GO,1903409,biological_process +43258,43258,sulfate transmembrane transport,GO,1902358,biological_process +43260,43260,iron ion transmembrane transport,GO,34755,biological_process +43286,43286,manganese ion transmembrane transport,GO,71421,biological_process +43299,43299,response to hydroperoxide,GO,33194,biological_process +43307,43307,positive regulation of protein catabolic process,GO,45732,biological_process +43313,43313,positive regulation of miRNA metabolic process,GO,2000630,biological_process +43330,43330,regulation of autophagy,GO,10506,biological_process +43337,43337,positive regulation of fatty acid oxidation,GO,46321,biological_process +43347,43347,regulation of mitochondrial fission,GO,90140,biological_process +43385,43385,positive regulation of extracellular matrix assembly,GO,1901203,biological_process +43403,43403,positive regulation of apoptotic process,GO,43065,biological_process +43410,43410,regulation of mitochondrial membrane permeability,GO,46902,biological_process +43446,43446,regulation of synaptic vesicle transport,GO,1902803,biological_process +43456,43456,platelet-derived growth factor receptor signaling pathway,GO,48008,biological_process +43474,43474,negative regulation of chemotaxis,GO,50922,biological_process +43485,43485,negative regulation of cytokine activity,GO,60302,biological_process +43505,43505,cell surface receptor signaling pathway involved in cell-cell signaling,GO,1905114,biological_process +43532,43532,positive regulation of T cell mediated immune response to tumor cell,GO,2842,biological_process +43538,43538,positive regulation of autophagy,GO,10508,biological_process +43539,43539,positive regulation by symbiont of host autophagy,GO,75044,biological_process +43540,43540,negative regulation of autophagy,GO,10507,biological_process +43542,43542,metal ion export,GO,70839,biological_process +43545,43545,export across plasma membrane,GO,140115,biological_process +43561,43561,regulation of fat cell differentiation,GO,45598,biological_process +43587,43587,"regulation of transcription, DNA-templated",GO,6355,biological_process +43596,43596,leukocyte apoptotic process,GO,71887,biological_process +43610,43610,response to cholesterol,GO,70723,biological_process +43614,43614,response to ethanol,GO,45471,biological_process +43622,43622,positive regulation of neurogenesis,GO,50769,biological_process +43629,43629,neuron differentiation,GO,30182,biological_process +43630,43630,glial cell differentiation,GO,10001,biological_process +43633,43633,striated muscle cell differentiation,GO,51146,biological_process +43638,43638,siderophore-dependent iron import into cell,GO,33214,biological_process +43655,43655,positive regulation of cell growth,GO,30307,biological_process +43656,43656,negative regulation of cell growth,GO,30308,biological_process +43674,43674,positive regulation of translation,GO,45727,biological_process +43739,43739,methionine metabolic process,GO,6555,biological_process +43744,43744,ornithine metabolic process,GO,6591,biological_process +43746,43746,homocysteine metabolic process,GO,50667,biological_process +43771,43771,response to peptidoglycan,GO,32494,biological_process +43791,43791,calcium-mediated signaling,GO,19722,biological_process +43804,43804,negative regulation of cell cycle,GO,45786,biological_process +43805,43805,positive regulation of cell cycle,GO,45787,biological_process +43811,43811,regulation of DNA recombination,GO,18,biological_process +43816,43816,embryonic pattern specification,GO,9880,biological_process +43826,43826,negative regulation of protein binding,GO,32091,biological_process +43835,43835,positive regulation of MAPK cascade,GO,43410,biological_process +43870,43870,positive regulation of epithelial cell migration,GO,10634,biological_process +43884,43884,regulation of chloride transport,GO,2001225,biological_process +43899,43899,positive regulation of cell division,GO,51781,biological_process +43916,43916,circadian rhythm,GO,7623,biological_process +43923,43923,glycolipid metabolic process,GO,6664,biological_process +43977,43977,positive regulation of protein dephosphorylation,GO,35307,biological_process +43996,43996,negative regulation of apoptotic process,GO,43066,biological_process +44025,44025,neuron projection morphogenesis,GO,48812,biological_process +44030,44030,negative regulation of signaling receptor activity,GO,2000272,biological_process +44033,44033,negative regulation of protein tyrosine kinase activity,GO,61099,biological_process +44074,44074,positive regulation of mononuclear cell migration,GO,71677,biological_process +44094,44094,actin polymerization or depolymerization,GO,8154,biological_process +44106,44106,regulation of feeding behavior,GO,60259,biological_process +44107,44107,mitochondrion organization,GO,7005,biological_process +44157,44157,response to bacterium,GO,9617,biological_process +44171,44171,response to peptide hormone,GO,43434,biological_process +44172,44172,response to gonadotropin,GO,34698,biological_process +44176,44176,positive regulation of receptor binding,GO,1900122,biological_process +44179,44179,positive regulation of signaling receptor activity,GO,2000273,biological_process +44192,44192,iron ion homeostasis,GO,55072,biological_process +44200,44200,protein localization to mitochondrion,GO,70585,biological_process +44207,44207,radial glial cell differentiation,GO,60019,biological_process +44217,44217,cellular response to oxidative stress,GO,34599,biological_process +44256,44256,iron ion transport,GO,6826,biological_process +44257,44257,cellular iron ion homeostasis,GO,6879,biological_process +44266,44266,neuron cellular homeostasis,GO,70050,biological_process +44270,44270,insulin secretion,GO,30073,biological_process +44284,44284,regulation of bone remodeling,GO,46850,biological_process +44298,44298,odontogenesis of dentin-containing tooth,GO,42475,biological_process +44303,44303,epithelial to mesenchymal transition,GO,1837,biological_process +44330,44330,negative regulation of endopeptidase activity,GO,10951,biological_process +44347,44347,negative regulation of protein sumoylation,GO,33234,biological_process +44348,44348,negative regulation of glycolytic process,GO,45820,biological_process +44366,44366,negative regulation of DNA biosynthetic process,GO,2000279,biological_process +44372,44372,regulation of T cell tolerance induction,GO,2664,biological_process +44405,44405,mesoderm development,GO,7498,biological_process +44417,44417,carnitine transport,GO,15879,biological_process +44426,44426,positive regulation of reactive oxygen species metabolic process,GO,2000379,biological_process +44433,44433,temperature homeostasis,GO,1659,biological_process +44441,44441,glycerol biosynthetic process,GO,6114,biological_process +44447,44447,purinergic nucleotide receptor signaling pathway,GO,35590,biological_process +44455,44455,complement receptor mediated signaling pathway,GO,2430,biological_process +44461,44461,activation of protein kinase activity,GO,32147,biological_process +44462,44462,intestinal absorption,GO,50892,biological_process +44486,44486,positive regulation of chemokine production,GO,32722,biological_process +44487,44487,negative regulation of chemokine production,GO,32682,biological_process +44495,44495,cellular response to growth factor stimulus,GO,71363,biological_process +44501,44501,negative regulation of toll-like receptor signaling pathway,GO,34122,biological_process +44502,44502,positive regulation of toll-like receptor signaling pathway,GO,34123,biological_process +44520,44520,response to oxidative stress,GO,6979,biological_process +44522,44522,response to molecule of bacterial origin,GO,2237,biological_process +44538,44538,regulation of immunoglobulin production,GO,2637,biological_process +44539,44539,positive regulation of prostaglandin secretion,GO,32308,biological_process +44545,44545,macrophage differentiation,GO,30225,biological_process +44559,44559,regulation of protein phosphorylation,GO,1932,biological_process +44569,44569,regulation of NIK/NF-kappaB signaling,GO,1901222,biological_process +44599,44599,positive regulation of proteasomal ubiquitin-dependent protein catabolic process,GO,32436,biological_process +44634,44634,protein glycosylation,GO,6486,biological_process +44646,44646,neutrophil mediated immunity,GO,2446,biological_process +44651,44651,inflammatory response to antigenic stimulus,GO,2437,biological_process +44652,44652,acute inflammatory response,GO,2526,biological_process +44653,44653,chronic inflammatory response,GO,2544,biological_process +44674,44674,gene expression,GO,10467,biological_process +44685,44685,regulation of interleukin-2 production,GO,32663,biological_process +44686,44686,regulation of interleukin-8 production,GO,32677,biological_process +44690,44690,regulation of vascular endothelial growth factor production,GO,10574,biological_process +44701,44701,regulation of interleukin-10 production,GO,32653,biological_process +44709,44709,regulation of cytokine production involved in inflammatory response,GO,1900015,biological_process +44730,44730,regulation of interleukin-4 production,GO,32673,biological_process +44733,44733,regulation of intestinal cholesterol absorption,GO,30300,biological_process +44755,44755,negative regulation of receptor binding,GO,1900121,biological_process +44797,44797,regulation of hepatocyte growth factor receptor signaling pathway,GO,1902202,biological_process +44802,44802,regulation of dopamine receptor signaling pathway,GO,60159,biological_process +44807,44807,negative regulation of synaptic transmission,GO,50805,biological_process +44832,44832,positive regulation of synaptic transmission,GO,50806,biological_process +44837,44837,regulation of transcription initiation from RNA polymerase II promoter,GO,60260,biological_process +44847,44847,negative regulation of dopamine metabolic process,GO,45963,biological_process +44855,44855,negative regulation of reactive oxygen species biosynthetic process,GO,1903427,biological_process +44887,44887,negative regulation of protein-containing complex disassembly,GO,43242,biological_process +44917,44917,positive regulation of RNA biosynthetic process,GO,1902680,biological_process +44955,44955,MAPK cascade,GO,165,biological_process +44959,44959,protein dephosphorylation,GO,6470,biological_process +44971,44971,regulation of growth,GO,40008,biological_process +44973,44973,regulation of angiogenesis,GO,45765,biological_process +44979,44979,response to wounding,GO,9611,biological_process +44980,44980,cognition,GO,50890,biological_process +44982,44982,rhythmic process,GO,48511,biological_process +44997,44997,negative regulation of blood coagulation,GO,30195,biological_process +45000,45000,regulation of circadian rhythm,GO,42752,biological_process +45004,45004,regulation of locomotion,GO,40012,biological_process +45017,45017,positive regulation of epithelial to mesenchymal transition,GO,10718,biological_process +45053,45053,response to sulfur dioxide,GO,10477,biological_process +45063,45063,response to carbon monoxide,GO,34465,biological_process +45089,45089,positive regulation of protein serine/threonine kinase activity,GO,71902,biological_process +45097,45097,negative regulation of type I interferon-mediated signaling pathway,GO,60339,biological_process +45099,45099,peptidyl-tyrosine dephosphorylation,GO,35335,biological_process +45103,45103,regulation of catalytic activity,GO,50790,biological_process +45118,45118,positive regulation of angiogenesis,GO,45766,biological_process +45124,45124,elastin metabolic process,GO,51541,biological_process +45129,45129,body fluid secretion,GO,7589,biological_process +45162,45162,excretion,GO,7588,biological_process +45163,45163,sodium ion transport,GO,6814,biological_process +45167,45167,cellular response to starvation,GO,9267,biological_process +45169,45169,dendrite development,GO,16358,biological_process +45173,45173,toll-like receptor 4 signaling pathway,GO,34142,biological_process +45175,45175,positive regulation of protein kinase activity,GO,45860,biological_process +45177,45177,positive regulation of peptidyl-tyrosine phosphorylation,GO,50731,biological_process +45193,45193,positive regulation of transcription by RNA polymerase II,GO,45944,biological_process +45199,45199,positive regulation of receptor-mediated endocytosis,GO,48260,biological_process +45200,45200,positive regulation of protein export from nucleus,GO,46827,biological_process +45230,45230,regulation of blood vessel remodeling,GO,60312,biological_process +45252,45252,oligosaccharide biosynthetic process,GO,9312,biological_process +45253,45253,negative regulation of viral process,GO,48525,biological_process +45261,45261,negative regulation by host of viral process,GO,44793,biological_process +45262,45262,retina homeostasis,GO,1895,biological_process +45270,45270,negative regulation of epithelial cell differentiation involved in kidney development,GO,2000697,biological_process +45278,45278,negative regulation of glutamine transport,GO,2000486,biological_process +45284,45284,negative regulation of calcium ion transport,GO,51926,biological_process +45312,45312,vasoconstriction,GO,42310,biological_process +45337,45337,positive regulation of vascular permeability,GO,43117,biological_process +45370,45370,negative regulation of cation channel activity,GO,2001258,biological_process +45381,45381,regulation of cell cycle,GO,51726,biological_process +45399,45399,negative regulation of cartilage development,GO,61037,biological_process +45408,45408,regulation of entry of bacterium into host cell,GO,2000535,biological_process +45410,45410,positive regulation of DNA binding,GO,43388,biological_process +45463,45463,neuron migration,GO,1764,biological_process +45481,45481,microtubule-based movement,GO,7018,biological_process +45502,45502,intracellular receptor signaling pathway,GO,30522,biological_process +45503,45503,steroid hormone mediated signaling pathway,GO,43401,biological_process +45504,45504,bile acid signaling pathway,GO,38183,biological_process +45505,45505,pattern recognition receptor signaling pathway,GO,2221,biological_process +45506,45506,intracellular signal transduction,GO,35556,biological_process +45513,45513,regulation of nitric-oxide synthase activity,GO,50999,biological_process +45521,45521,multicellular organism development,GO,7275,biological_process +45525,45525,natural killer cell activation,GO,30101,biological_process +45526,45526,T cell activation,GO,42110,biological_process +45527,45527,B cell activation,GO,42113,biological_process +45562,45562,immunoglobulin mediated immune response,GO,16064,biological_process +45565,45565,negative regulation of blood pressure,GO,45776,biological_process +45576,45576,actin filament polymerization,GO,30041,biological_process +45583,45583,positive regulation of T cell activation,GO,50870,biological_process +45624,45624,regulation of gamma-delta T cell differentiation,GO,45586,biological_process +45630,45630,regulation of extrathymic T cell differentiation,GO,33082,biological_process +45631,45631,regulation of regulatory T cell differentiation,GO,45589,biological_process +45644,45644,activation of MAPKK activity,GO,186,biological_process +45645,45645,positive regulation of JUN kinase activity,GO,43507,biological_process +45652,45652,antibacterial humoral response,GO,19731,biological_process +45675,45675,response to electrical stimulus,GO,51602,biological_process +45678,45678,positive regulation of cell activation,GO,50867,biological_process +45681,45681,response to glucose,GO,9749,biological_process +45692,45692,receptor catabolic process,GO,32801,biological_process +45694,45694,negative regulation of G1/S transition of mitotic cell cycle,GO,2000134,biological_process +45702,45702,reactive oxygen species metabolic process,GO,72593,biological_process +45712,45712,endoplasmic reticulum organization,GO,7029,biological_process +45745,45745,regulation of insulin secretion,GO,50796,biological_process +45793,45793,artery morphogenesis,GO,48844,biological_process +45796,45796,negative regulation of peptidase activity,GO,10466,biological_process +45799,45799,positive regulation of peptidase activity,GO,10952,biological_process +45814,45814,regulation of mitochondrial depolarization,GO,51900,biological_process +45815,45815,negative regulation of DNA binding,GO,43392,biological_process +45843,45843,positive regulation of chemotaxis,GO,50921,biological_process +45845,45845,positive regulation of axon extension,GO,45773,biological_process +45848,45848,positive regulation of smooth muscle cell migration,GO,14911,biological_process +45850,45850,extracellular matrix disassembly,GO,22617,biological_process +45856,45856,positive regulation of protein tyrosine kinase activity,GO,61098,biological_process +45860,45860,positive regulation of DNA-binding transcription factor activity,GO,51091,biological_process +45870,45870,negative regulation of cytolysis,GO,45918,biological_process +45889,45889,negative regulation of leukocyte cell-cell adhesion,GO,1903038,biological_process +45890,45890,positive regulation of natural killer cell activation,GO,32816,biological_process +45891,45891,positive regulation of lymphocyte proliferation,GO,50671,biological_process +45892,45892,regulation of natural killer cell differentiation,GO,32823,biological_process +45894,45894,positive regulation of natural killer cell mediated cytotoxicity,GO,45954,biological_process +45902,45902,positive regulation of cell adhesion,GO,45785,biological_process +45903,45903,regulation of synapse organization,GO,50807,biological_process +45919,45919,amyloid-beta clearance,GO,97242,biological_process +45927,45927,negative regulation of protein localization to plasma membrane,GO,1903077,biological_process +45968,45968,negative regulation of macroautophagy,GO,16242,biological_process +45981,45981,extrinsic apoptotic signaling pathway,GO,97191,biological_process +45994,45994,dendritic cell chemotaxis,GO,2407,biological_process +46014,46014,response to lead ion,GO,10288,biological_process +46017,46017,response to copper ion,GO,46688,biological_process +46018,46018,response to cobalt ion,GO,32025,biological_process +46025,46025,response to zinc ion,GO,10043,biological_process +46041,46041,response to insulin,GO,32868,biological_process +46049,46049,positive regulation of kinase activity,GO,33674,biological_process +46064,46064,negative regulation of wound healing,GO,61045,biological_process +46080,46080,negative regulation of branching involved in lung morphogenesis,GO,61048,biological_process +46082,46082,negative regulation of granulocyte differentiation,GO,30853,biological_process +46087,46087,positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus,GO,1901522,biological_process +46088,46088,cellular response to amino acid starvation,GO,34198,biological_process +46101,46101,regulation of inflammatory response,GO,50727,biological_process +46113,46113,positive regulation of neuron death,GO,1901216,biological_process +46145,46145,response to UV,GO,9411,biological_process +46152,46152,regulation of synaptic vesicle exocytosis,GO,2000300,biological_process +46168,46168,cell surface receptor signaling pathway,GO,7166,biological_process +46169,46169,apoptotic signaling pathway,GO,97190,biological_process +46198,46198,regulation of cell adhesion,GO,30155,biological_process +46215,46215,intracellular pH elevation,GO,51454,biological_process +46268,46268,positive regulation of complement activation,GO,45917,biological_process +46294,46294,positive regulation of gamma-delta T cell activation,GO,46645,biological_process +46295,46295,positive regulation of T cell proliferation,GO,42102,biological_process +46296,46296,negative regulation of T cell proliferation,GO,42130,biological_process +46332,46332,positive regulation of phosphoprotein phosphatase activity,GO,32516,biological_process +46338,46338,protein localization to plasma membrane,GO,72659,biological_process +46345,46345,negative regulation of ceramide biosynthetic process,GO,1900060,biological_process +46346,46346,positive regulation of ceramide biosynthetic process,GO,2000304,biological_process +46356,46356,negative regulation of heart contraction,GO,45822,biological_process +46361,46361,regulation of signal transduction by p53 class mediator,GO,1901796,biological_process +46368,46368,negative regulation of gene silencing by miRNA,GO,60965,biological_process +46375,46375,cell-cell adhesion,GO,98609,biological_process +46378,46378,lymphocyte differentiation,GO,30098,biological_process +46379,46379,gastric acid secretion,GO,1696,biological_process +46387,46387,folic acid metabolic process,GO,46655,biological_process +46397,46397,regulation of I-kappaB kinase/NF-kappaB signaling,GO,43122,biological_process +46403,46403,regulation of small GTPase mediated signal transduction,GO,51056,biological_process +46406,46406,regulation of TOR signaling,GO,32006,biological_process +46414,46414,regulation of glucagon secretion,GO,70092,biological_process +46471,46471,homeostasis of number of cells,GO,48872,biological_process +46483,46483,regulation of natural killer cell activation,GO,32814,biological_process +46503,46503,positive regulation of viral entry into host cell,GO,46598,biological_process +46529,46529,BMP signaling pathway,GO,30509,biological_process +46531,46531,Notch signaling pathway,GO,7219,biological_process +46533,46533,activin receptor signaling pathway,GO,32924,biological_process +46534,46534,transforming growth factor beta receptor signaling pathway,GO,7179,biological_process +46537,46537,triglyceride homeostasis,GO,70328,biological_process +46539,46539,glucose homeostasis,GO,42593,biological_process +46540,46540,lipid homeostasis,GO,55088,biological_process +46570,46570,"transcription, DNA-templated",GO,6351,biological_process +46576,46576,postsynaptic modulation of chemical synaptic transmission,GO,99170,biological_process +46622,46622,antigen processing and presentation of peptide antigen,GO,48002,biological_process +46625,46625,positive regulation of killing of cells of other organism,GO,51712,biological_process +46630,46630,regulation of cholesterol transporter activity,GO,60694,biological_process +46638,46638,regulation of histone methylation,GO,31060,biological_process +46647,46647,inner ear development,GO,48839,biological_process +46648,46648,epidermis development,GO,8544,biological_process +46674,46674,cellular response to reactive oxygen species,GO,34614,biological_process +46693,46693,myelination,GO,42552,biological_process +46706,46706,canonical Wnt signaling pathway,GO,60070,biological_process +46724,46724,negative regulation of osteoclast differentiation,GO,45671,biological_process +46725,46725,positive regulation of protein localization to nucleus,GO,1900182,biological_process +46730,46730,positive regulation of cyclin-dependent protein serine/threonine kinase activity,GO,45737,biological_process +46734,46734,cell adhesion mediated by integrin,GO,33627,biological_process +46767,46767,cellular response to cytokine stimulus,GO,71345,biological_process +46768,46768,positive regulation of lipid transporter activity,GO,110113,biological_process +46772,46772,transport across blood-brain barrier,GO,150104,biological_process +46796,46796,negative regulation of endothelial cell proliferation,GO,1937,biological_process +46806,46806,T cell costimulation,GO,31295,biological_process +46811,46811,negative regulation of cytokine production involved in immune response,GO,2719,biological_process +46816,46816,positive regulation of tissue remodeling,GO,34105,biological_process +46817,46817,positive regulation of cellular extravasation,GO,2693,biological_process +46818,46818,positive regulation of T cell migration,GO,2000406,biological_process +46870,46870,proteoglycan biosynthetic process,GO,30166,biological_process +46874,46874,response to estrogen,GO,43627,biological_process +46877,46877,response to leptin,GO,44321,biological_process +46889,46889,killing by host of symbiont cells,GO,51873,biological_process +46893,46893,primary miRNA processing,GO,31053,biological_process +46910,46910,adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway,GO,7193,biological_process +46911,46911,phospholipase C-activating G protein-coupled receptor signaling pathway,GO,7200,biological_process +46923,46923,regulation of tyrosine phosphorylation of STAT protein,GO,42509,biological_process +46938,46938,manganese ion transport,GO,6828,biological_process +46949,46949,energy reserve metabolic process,GO,6112,biological_process +46956,46956,adherens junction organization,GO,34332,biological_process +46960,46960,response to mechanical stimulus,GO,9612,biological_process +46963,46963,negative regulation of intrinsic apoptotic signaling pathway,GO,2001243,biological_process +46999,46999,biological process involved in interaction with symbiont,GO,51702,biological_process +47011,47011,positive regulation of cell death,GO,10942,biological_process +47024,47024,regulation of protein kinase A signaling,GO,10738,biological_process +47029,47029,myoblast differentiation,GO,45445,biological_process +47064,47064,protein deubiquitination,GO,16579,biological_process +47066,47066,protein ubiquitination,GO,16567,biological_process +47093,47093,negative regulation of production of miRNAs involved in gene silencing by miRNA,GO,1903799,biological_process +47119,47119,regulation of cell size,GO,8361,biological_process +47126,47126,establishment of endothelial barrier,GO,61028,biological_process +47128,47128,"CD4-positive, alpha-beta T cell differentiation",GO,43367,biological_process +47164,47164,regulation of toll-like receptor 9 signaling pathway,GO,34163,biological_process +47231,47231,positive regulation of interleukin-1 production,GO,32732,biological_process +47232,47232,regulation of interleukin-1 beta production,GO,32651,biological_process +47239,47239,carnitine metabolic process,GO,9437,biological_process +47242,47242,cytokine-mediated signaling pathway,GO,19221,biological_process +47283,47283,bile acid and bile salt transport,GO,15721,biological_process +47300,47300,negative regulation of protein catabolic process,GO,42177,biological_process +47308,47308,negative regulation of locomotion,GO,40013,biological_process +47353,47353,regulation of endothelial cell apoptotic process,GO,2000351,biological_process +47355,47355,positive regulation of epithelial cell apoptotic process,GO,1904037,biological_process +47378,47378,epidermal growth factor receptor signaling pathway,GO,7173,biological_process +47382,47382,positive regulation of smooth muscle contraction,GO,45987,biological_process +47462,47462,negative regulation of neuron death,GO,1901215,biological_process +47543,47543,regulation of protein ADP-ribosylation,GO,10835,biological_process +47547,47547,positive regulation of transforming growth factor beta3 production,GO,32916,biological_process +47559,47559,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process,GO,43280,biological_process +47564,47564,prostaglandin secretion,GO,32310,biological_process +47585,47585,intrinsic apoptotic signaling pathway in response to DNA damage,GO,8630,biological_process +47602,47602,regulation of neuron death,GO,1901214,biological_process +47622,47622,positive regulation of fatty acid beta-oxidation,GO,32000,biological_process +47633,47633,detection of biotic stimulus,GO,9595,biological_process +47671,47671,negative regulation of B cell apoptotic process,GO,2903,biological_process +47672,47672,positive regulation of B cell apoptotic process,GO,2904,biological_process +47676,47676,antigen processing and presentation of peptide antigen via MHC class I,GO,2474,biological_process +47682,47682,positive regulation of wound healing,GO,90303,biological_process +47683,47683,positive regulation of cell-substrate adhesion,GO,10811,biological_process +47685,47685,regulation of fibroblast migration,GO,10762,biological_process +47704,47704,regulation of T cell migration,GO,2000404,biological_process +47716,47716,extrinsic apoptotic signaling pathway via death domain receptors,GO,8625,biological_process +47733,47733,response to cytokine,GO,34097,biological_process +47737,47737,regulation of NK T cell differentiation,GO,51136,biological_process +47754,47754,positive regulation of myeloid cell apoptotic process,GO,33034,biological_process +47767,47767,cell differentiation in hindbrain,GO,21533,biological_process +47778,47778,cell-cell junction organization,GO,45216,biological_process +47784,47784,cell cycle,GO,7049,biological_process +47807,47807,cell adhesion,GO,7155,biological_process +47818,47818,positive regulation of hair follicle development,GO,51798,biological_process +47821,47821,response to linoleic acid,GO,70543,biological_process +47828,47828,muscle hypertrophy,GO,14896,biological_process +47829,47829,cellular response to virus,GO,98586,biological_process +47831,47831,respiratory burst involved in defense response,GO,2679,biological_process +47844,47844,sphingolipid biosynthetic process,GO,30148,biological_process +47884,47884,regulation of astrocyte activation,GO,61888,biological_process +47885,47885,positive regulation of neuroinflammatory response,GO,150078,biological_process +47893,47893,regulation of low-density lipoprotein particle clearance,GO,10988,biological_process +47900,47900,protein autophosphorylation,GO,46777,biological_process +47901,47901,peptidyl-serine phosphorylation,GO,18105,biological_process +47902,47902,peptidyl-threonine phosphorylation,GO,18107,biological_process +47903,47903,peptidyl-tyrosine phosphorylation,GO,18108,biological_process +47937,47937,response to heat,GO,9408,biological_process +47945,47945,positive regulation of protein localization to plasma membrane,GO,1903078,biological_process +48023,48023,regulation of response to osmotic stress,GO,47484,biological_process +48044,48044,ossification,GO,1503,biological_process +48057,48057,positive regulation of TOR signaling,GO,32008,biological_process +48071,48071,positive regulation of membrane permeability,GO,1905710,biological_process +48083,48083,positive regulation of gene silencing by miRNA,GO,2000637,biological_process +48102,48102,negative regulation of neuron apoptotic process,GO,43524,biological_process +48112,48112,positive regulation of dendritic cell cytokine production,GO,2732,biological_process +48116,48116,mitotic cell cycle,GO,278,biological_process +48135,48135,positive regulation of cardiac muscle hypertrophy,GO,10613,biological_process +48144,48144,regulation of endothelial cell proliferation,GO,1936,biological_process +48164,48164,response to virus,GO,9615,biological_process +48170,48170,synapse assembly,GO,7416,biological_process +48171,48171,neuromuscular junction development,GO,7528,biological_process +48175,48175,negative regulation of myoblast differentiation,GO,45662,biological_process +48182,48182,liver development,GO,1889,biological_process +48186,48186,astrocyte cell migration,GO,43615,biological_process +48206,48206,T-helper cell differentiation,GO,42093,biological_process +48207,48207,positive regulation of calcium ion import,GO,90280,biological_process +48208,48208,regulation of ER to Golgi vesicle-mediated transport,GO,60628,biological_process +48244,48244,cell-cell adhesion via plasma-membrane adhesion molecules,GO,98742,biological_process +48245,48245,dopaminergic neuron differentiation,GO,71542,biological_process +48248,48248,generation of precursor metabolites and energy,GO,6091,biological_process +48252,48252,negative regulation of protein processing,GO,10955,biological_process +48263,48263,nodal signaling pathway,GO,38092,biological_process +48270,48270,sphingosine metabolic process,GO,6670,biological_process +48284,48284,regulation of branching involved in salivary gland morphogenesis,GO,60693,biological_process +48285,48285,positive regulation of extrinsic apoptotic signaling pathway,GO,2001238,biological_process +48293,48293,neuron apoptotic process,GO,51402,biological_process +48326,48326,heterotypic cell-cell adhesion,GO,34113,biological_process +48352,48352,regulation of cAMP-dependent protein kinase activity,GO,2000479,biological_process +48381,48381,"regulation of synaptic transmission, glutamatergic",GO,51966,biological_process +48396,48396,regulation of bicellular tight junction assembly,GO,2000810,biological_process +48409,48409,negative regulation of transforming growth factor beta receptor signaling pathway,GO,30512,biological_process +48424,48424,astrocyte activation,GO,48143,biological_process +48436,48436,regulation of endosomal vesicle fusion,GO,1905364,biological_process +48456,48456,positive regulation of T cell mediated cytotoxicity,GO,1916,biological_process +48457,48457,negative regulation of T cell mediated cytotoxicity,GO,1915,biological_process +48494,48494,viral genome replication,GO,19079,biological_process +48497,48497,acute inflammatory response to antigenic stimulus,GO,2438,biological_process +48526,48526,leukocyte homeostasis,GO,1776,biological_process +48532,48532,positive regulation of T cell differentiation,GO,45582,biological_process +48540,48540,membrane disruption in other organism,GO,51673,biological_process +48582,48582,negative regulation of neuroinflammatory response,GO,150079,biological_process +48583,48583,regulation of microglial cell activation,GO,1903978,biological_process +48596,48596,positive regulation of T cell mediated immunity,GO,2711,biological_process +48602,48602,ATP biosynthetic process,GO,6754,biological_process +48604,48604,positive regulation of phagocytosis,GO,50766,biological_process +48617,48617,positive regulation of oxidative stress-induced neuron death,GO,1903223,biological_process +48618,48618,positive regulation of neuron apoptotic process,GO,43525,biological_process +48630,48630,neutrophil activation,GO,42119,biological_process +48632,48632,macrophage activation,GO,42116,biological_process +48638,48638,helper T cell extravasation,GO,35684,biological_process +48639,48639,mitochondrion localization,GO,51646,biological_process +48656,48656,positive regulation of T-helper 1 type immune response,GO,2827,biological_process +48675,48675,proteolysis,GO,6508,biological_process +48680,48680,cellular response to manganese ion,GO,71287,biological_process +48685,48685,negative regulation of inflammatory response to antigenic stimulus,GO,2862,biological_process +48696,48696,positive regulation of fat cell differentiation,GO,45600,biological_process +48697,48697,regulation of brown fat cell differentiation,GO,90335,biological_process +48745,48745,acetaldehyde metabolic process,GO,6117,biological_process +48765,48765,positive regulation of protein deacetylation,GO,90312,biological_process +48787,48787,positive regulation of MAP kinase activity,GO,43406,biological_process +48798,48798,negative regulation of skeletal muscle tissue development,GO,48642,biological_process +48799,48799,negative regulation of angiogenesis,GO,16525,biological_process +48814,48814,regulation of urea metabolic process,GO,34255,biological_process +48826,48826,regulation of ERK1 and ERK2 cascade,GO,70372,biological_process +48838,48838,TRIF-dependent toll-like receptor signaling pathway,GO,35666,biological_process +48849,48849,response to hypoxia,GO,1666,biological_process +48852,48852,cell aging,GO,7569,biological_process +48883,48883,MyD88-independent toll-like receptor signaling pathway,GO,2756,biological_process +48887,48887,T cell extravasation,GO,72683,biological_process +48888,48888,regulation of interferon-gamma-mediated signaling pathway,GO,60334,biological_process +48914,48914,T cell migration,GO,72678,biological_process +48928,48928,regulation of lysosomal lumen pH,GO,35751,biological_process +48944,48944,cytoskeleton organization,GO,7010,biological_process +48958,48958,antimicrobial humoral response,GO,19730,biological_process +49005,49005,protein folding,GO,6457,biological_process +49031,49031,positive regulation of vasoconstriction,GO,45907,biological_process +49032,49032,negative regulation of vasoconstriction,GO,45906,biological_process +49048,49048,leptin-mediated signaling pathway,GO,33210,biological_process +49049,49049,negative regulation of appetite,GO,32099,biological_process +49083,49083,positive regulation of Ras protein signal transduction,GO,46579,biological_process +49087,49087,ceramide metabolic process,GO,6672,biological_process +49099,49099,intrinsic apoptotic signaling pathway in response to oxidative stress,GO,8631,biological_process +49144,49144,negative regulation of smooth muscle cell proliferation,GO,48662,biological_process +49151,49151,response to inactivity,GO,14854,biological_process +49152,49152,response to activity,GO,14823,biological_process +49163,49163,positive regulation of protein K63-linked ubiquitination,GO,1902523,biological_process +49178,49178,positive regulation of glycoprotein biosynthetic process,GO,10560,biological_process +49180,49180,negative regulation of I-kappaB kinase/NF-kappaB signaling,GO,43124,biological_process +49182,49182,positive regulation of leukocyte adhesion to vascular endothelial cell,GO,1904996,biological_process +49195,49195,negative regulation of macrophage differentiation,GO,45650,biological_process +49206,49206,negative regulation of hydrogen peroxide-induced neuron death,GO,1903208,biological_process +49218,49218,killing of cells of other organism,GO,31640,biological_process +49243,49243,regulation of neuroinflammatory response,GO,150077,biological_process +49258,49258,detection of fungus,GO,16046,biological_process +49303,49303,positive regulation of smooth muscle cell proliferation,GO,48661,biological_process +49308,49308,positive regulation of histone acetylation,GO,35066,biological_process +49314,49314,antigen processing and presentation of endogenous peptide antigen via MHC class I,GO,19885,biological_process +49317,49317,positive regulation of glutamate metabolic process,GO,2000213,biological_process +49330,49330,muscle organ development,GO,7517,biological_process +49411,49411,tangential migration from the subventricular zone to the olfactory bulb,GO,22028,biological_process +49418,49418,negative regulation of lipid storage,GO,10888,biological_process +49440,49440,response to amyloid-beta,GO,1904645,biological_process +49441,49441,response to muramyl dipeptide,GO,32495,biological_process +49465,49465,regulation of protein stability,GO,31647,biological_process +49481,49481,motor behavior,GO,61744,biological_process +49485,49485,nucleotide-binding oligomerization domain containing signaling pathway,GO,70423,biological_process +49504,49504,positive regulation of type 2 immune response,GO,2830,biological_process +49506,49506,positive regulation of T-helper 17 type immune response,GO,2000318,biological_process +49509,49509,"positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation",GO,32831,biological_process +49516,49516,superoxide metabolic process,GO,6801,biological_process +49524,49524,metanephric tubule morphogenesis,GO,72173,biological_process +49540,49540,cell-matrix adhesion,GO,7160,biological_process +49551,49551,positive regulation of synapse assembly,GO,51965,biological_process +49558,49558,T cell differentiation,GO,30217,biological_process +49568,49568,positive regulation of humoral immune response mediated by circulating immunoglobulin,GO,2925,biological_process +49591,49591,vascular endothelial growth factor receptor signaling pathway,GO,48010,biological_process +49621,49621,negative regulation of cysteine-type endopeptidase activity,GO,2000117,biological_process +49625,49625,adenylate cyclase-activating G protein-coupled receptor signaling pathway,GO,7189,biological_process +49636,49636,negative regulation of protein autophosphorylation,GO,31953,biological_process +49658,49658,sexual reproduction,GO,19953,biological_process +49682,49682,response to tumor necrosis factor,GO,34612,biological_process +49683,49683,response to interferon-gamma,GO,34341,biological_process +49684,49684,response to interleukin-1,GO,70555,biological_process +49687,49687,response to interleukin-18,GO,70673,biological_process +49698,49698,response to interleukin-12,GO,70671,biological_process +49712,49712,phospholipid translocation,GO,45332,biological_process +49718,49718,chemokine-mediated signaling pathway,GO,70098,biological_process +49758,49758,positive regulation of positive chemotaxis,GO,50927,biological_process +49763,49763,regulation of neuroblast proliferation,GO,1902692,biological_process +49771,49771,positive regulation of natural killer cell proliferation,GO,32819,biological_process +49783,49783,regulation of DNA-templated transcription in response to stress,GO,43620,biological_process +49788,49788,toll-like receptor signaling pathway,GO,2224,biological_process +49789,49789,regulation of proteasomal ubiquitin-dependent protein catabolic process,GO,32434,biological_process +49829,49829,positive regulation of smooth muscle cell apoptotic process,GO,34393,biological_process +49839,49839,negative regulation of transforming growth factor beta production,GO,71635,biological_process +49840,49840,regulation of transforming growth factor beta2 production,GO,32909,biological_process +49845,49845,positive regulation of endothelial cell proliferation,GO,1938,biological_process +49849,49849,T cell proliferation,GO,42098,biological_process +49862,49862,negative regulation of transforming growth factor beta2 production,GO,32912,biological_process +49878,49878,axon regeneration,GO,31103,biological_process +49887,49887,Ras protein signal transduction,GO,7265,biological_process +49908,49908,eye photoreceptor cell differentiation,GO,1754,biological_process +49927,49927,positive regulation of anion channel activity,GO,1901529,biological_process +49956,49956,positive regulation of stress-activated MAPK cascade,GO,32874,biological_process +49960,49960,adhesion of symbiont to host,GO,44406,biological_process +49971,49971,B cell proliferation,GO,42100,biological_process +50037,50037,biomineral tissue development,GO,31214,biological_process +50041,50041,enzyme linked receptor protein signaling pathway,GO,7167,biological_process +50049,50049,skeletal muscle cell differentiation,GO,35914,biological_process +50051,50051,positive regulation of interleukin-17 production,GO,32740,biological_process +50068,50068,intrinsic apoptotic signaling pathway in response to osmotic stress,GO,8627,biological_process +50073,50073,neural crest cell migration involved in autonomic nervous system development,GO,1901166,biological_process +50107,50107,response to exogenous dsRNA,GO,43330,biological_process +50140,50140,negative regulation of interleukin-1 production,GO,32692,biological_process +50158,50158,cartilage development,GO,51216,biological_process +50170,50170,leukocyte chemotaxis,GO,30595,biological_process +50203,50203,vasculogenesis,GO,1570,biological_process +50227,50227,positive regulation of metalloendopeptidase activity,GO,1904685,biological_process +50229,50229,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,GO,43154,biological_process +50232,50232,central nervous system neuron development,GO,21954,biological_process +50237,50237,response to acidic pH,GO,10447,biological_process +50242,50242,fatty acid beta-oxidation,GO,6635,biological_process +50255,50255,leukocyte migration involved in inflammatory response,GO,2523,biological_process +50258,50258,lymphocyte migration,GO,72676,biological_process +50292,50292,insulin receptor signaling pathway,GO,8286,biological_process +50305,50305,odontogenesis,GO,42476,biological_process +50306,50306,positive regulation of GTPase activity,GO,43547,biological_process +50318,50318,regulation of neuron maturation,GO,14041,biological_process +50328,50328,positive regulation of macrophage activation,GO,43032,biological_process +50335,50335,wound healing,GO,42060,biological_process +50341,50341,fucosylation,GO,36065,biological_process +50349,50349,response to yeast,GO,1878,biological_process +50365,50365,negative regulation of mononuclear cell proliferation,GO,32945,biological_process +50366,50366,positive regulation of mononuclear cell proliferation,GO,32946,biological_process +50371,50371,regulation of establishment of endothelial barrier,GO,1903140,biological_process +50381,50381,response to UV-B,GO,10224,biological_process +50420,50420,regulation of bone mineralization,GO,30500,biological_process +50449,50449,L-arginine transport,GO,1902023,biological_process +50454,50454,positive regulation of immature T cell proliferation,GO,33091,biological_process +50476,50476,T cell proliferation involved in immune response,GO,2309,biological_process +50484,50484,positive regulation of protein targeting to membrane,GO,90314,biological_process +50496,50496,heart development,GO,7507,biological_process +50498,50498,hemopoiesis,GO,30097,biological_process +50499,50499,endocytic recycling,GO,32456,biological_process +50506,50506,negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway,GO,1902236,biological_process +50512,50512,negative regulation of lipopolysaccharide-mediated signaling pathway,GO,31665,biological_process +50522,50522,exploration behavior,GO,35640,biological_process +50542,50542,regulation of gene expression by genetic imprinting,GO,6349,biological_process +50547,50547,regulation of receptor signaling pathway via JAK-STAT,GO,46425,biological_process +50549,50549,double-strand break repair via nonhomologous end joining,GO,6303,biological_process +50576,50576,tumor necrosis factor-mediated signaling pathway,GO,33209,biological_process +50606,50606,positive regulation of mitotic nuclear division,GO,45840,biological_process +50615,50615,negative regulation of glucose transmembrane transport,GO,10829,biological_process +50624,50624,fatty acid oxidation,GO,19395,biological_process +50625,50625,heart valve morphogenesis,GO,3179,biological_process +50659,50659,vacuolar acidification,GO,7035,biological_process +50711,50711,O-glycan processing,GO,16266,biological_process +50734,50734,actin polymerization-dependent cell motility,GO,70358,biological_process +50739,50739,activation of MAPK activity,GO,187,biological_process +50757,50757,regulation of response to food,GO,32095,biological_process +50774,50774,positive regulation of glial cell proliferation,GO,60252,biological_process +50798,50798,efferent axon development in a lateral line nerve,GO,48894,biological_process +50817,50817,toll-like receptor 2 signaling pathway,GO,34134,biological_process +50818,50818,MyD88-dependent toll-like receptor signaling pathway,GO,2755,biological_process +50846,50846,smooth muscle adaptation,GO,14805,biological_process +50870,50870,negative regulation of NF-kappaB transcription factor activity,GO,32088,biological_process +50904,50904,positive regulation of bone mineralization,GO,30501,biological_process +50920,50920,protein homooligomerization,GO,51260,biological_process +50958,50958,regulation of CAMKK-AMPK signaling cascade,GO,1905289,biological_process +50960,50960,skeletal system development,GO,1501,biological_process +50963,50963,sphingoid catabolic process,GO,46521,biological_process +50965,50965,positive regulation of type I interferon production,GO,32481,biological_process +50972,50972,sex differentiation,GO,7548,biological_process +51009,51009,positive regulation of phosphatidylinositol 3-kinase activity,GO,43552,biological_process +51025,51025,positive regulation of NK T cell activation,GO,51135,biological_process +51049,51049,negative regulation of excitatory postsynaptic potential,GO,90394,biological_process +51071,51071,regulation of ruffle assembly,GO,1900027,biological_process +51085,51085,excitatory postsynaptic potential,GO,60079,biological_process +51091,51091,Fc-epsilon receptor signaling pathway,GO,38095,biological_process +51115,51115,keratinocyte differentiation,GO,30216,biological_process +51131,51131,regulation of neutrophil chemotaxis,GO,90022,biological_process +51143,51143,regulation of tumor necrosis factor-mediated signaling pathway,GO,10803,biological_process +51155,51155,lymphocyte chemotaxis,GO,48247,biological_process +51160,51160,neuron projection arborization,GO,140058,biological_process +51164,51164,regulation of T cell homeostatic proliferation,GO,46013,biological_process +51209,51209,angiogenesis,GO,1525,biological_process +51245,51245,negative regulation of bone mineralization,GO,30502,biological_process +51279,51279,adaptive immune response,GO,2250,biological_process +51314,51314,lipid localization,GO,10876,biological_process +51327,51327,positive regulation of blood microparticle formation,GO,2000334,biological_process +51338,51338,positive regulation of insulin secretion,GO,32024,biological_process +51359,51359,response to hydrogen peroxide,GO,42542,biological_process +51361,51361,apoptotic process,GO,6915,biological_process +51362,51362,neuron death,GO,70997,biological_process +51387,51387,"positive regulation of synaptic transmission, glutamatergic",GO,51968,biological_process +51389,51389,positive regulation of receptor signaling pathway via STAT,GO,1904894,biological_process +51401,51401,negative regulation of biomineral tissue development,GO,70168,biological_process +51415,51415,protein tetramerization,GO,51262,biological_process +51419,51419,regulation of striated muscle tissue development,GO,16202,biological_process +51424,51424,cell-substrate junction assembly,GO,7044,biological_process +51429,51429,axonal fasciculation,GO,7413,biological_process +51433,51433,ventricular cardiac muscle tissue morphogenesis,GO,55010,biological_process +51449,51449,germ cell development,GO,7281,biological_process +51457,51457,protein export from nucleus,GO,6611,biological_process +51463,51463,response to ionizing radiation,GO,10212,biological_process +51487,51487,negative regulation of cyclin-dependent protein serine/threonine kinase activity,GO,45736,biological_process +51516,51516,thymocyte migration,GO,72679,biological_process +51522,51522,triglyceride metabolic process,GO,6641,biological_process +51532,51532,gamma-delta T cell differentiation,GO,42492,biological_process +51533,51533,receptor-mediated virion attachment to host cell,GO,46813,biological_process +51555,51555,positive regulation of production of miRNAs involved in gene silencing by miRNA,GO,1903800,biological_process +51565,51565,membrane protein intracellular domain proteolysis,GO,31293,biological_process +51566,51566,response to muscle stretch,GO,35994,biological_process +51573,51573,aorta development,GO,35904,biological_process +51598,51598,positive regulation of fibroblast proliferation,GO,48146,biological_process +51599,51599,negative regulation of peroxidase activity,GO,2000469,biological_process +51603,51603,response to morphine,GO,43278,biological_process +51675,51675,regulation of gastric motility,GO,1905333,biological_process +51679,51679,post-translational protein modification,GO,43687,biological_process +51701,51701,response to sucrose,GO,9744,biological_process +51735,51735,protein import into nucleus,GO,6606,biological_process +51770,51770,positive regulation of transcription regulatory region DNA binding,GO,2000679,biological_process +51788,51788,positive regulation of dendritic cell antigen processing and presentation,GO,2606,biological_process +51796,51796,positive regulation of I-kappaB kinase/NF-kappaB signaling,GO,43123,biological_process +51806,51806,hindbrain tangential cell migration,GO,21934,biological_process +51820,51820,glial cell apoptotic process,GO,34349,biological_process +51895,51895,negative regulation of blood vessel endothelial cell migration,GO,43537,biological_process +51896,51896,positive regulation of blood vessel endothelial cell migration,GO,43536,biological_process +51935,51935,negative regulation of glial cell apoptotic process,GO,34351,biological_process +51937,51937,positive regulation of glycolytic process,GO,45821,biological_process +51972,51972,positive regulation of eating behavior,GO,1904000,biological_process +52019,52019,"regulation of retrograde transport, endosome to Golgi",GO,1905279,biological_process +52065,52065,negative regulation of neuron migration,GO,2001223,biological_process +52068,52068,cardiac muscle hypertrophy,GO,3300,biological_process +52094,52094,kidney development,GO,1822,biological_process +52115,52115,osteoclast differentiation,GO,30316,biological_process +52135,52135,detection of bacterium,GO,16045,biological_process +52136,52136,response to symbiotic bacterium,GO,9609,biological_process +52150,52150,bone morphogenesis,GO,60349,biological_process +52155,52155,bone growth,GO,98868,biological_process +52168,52168,regulation of tumor necrosis factor production,GO,32680,biological_process +52182,52182,noradrenergic neuron differentiation,GO,3357,biological_process +52206,52206,positive regulation of fever generation,GO,31622,biological_process +52209,52209,leukocyte cell-cell adhesion,GO,7159,biological_process +52234,52234,carnitine transmembrane transport,GO,1902603,biological_process +52237,52237,maintenance of gastrointestinal epithelium,GO,30277,biological_process +52240,52240,somatic stem cell population maintenance,GO,35019,biological_process +52241,52241,skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration,GO,14834,biological_process +52263,52263,positive regulation of fibroblast migration,GO,10763,biological_process +52268,52268,white fat cell differentiation,GO,50872,biological_process +52304,52304,positive regulation of ERK1 and ERK2 cascade,GO,70374,biological_process +52337,52337,eye photoreceptor cell development,GO,42462,biological_process +52340,52340,positive regulation of viral genome replication,GO,45070,biological_process +52341,52341,regulation of single stranded viral RNA replication via double stranded DNA intermediate,GO,45091,biological_process +52349,52349,natural killer cell activation involved in immune response,GO,2323,biological_process +52353,52353,heart valve development,GO,3170,biological_process +52358,52358,regulation of kidney size,GO,35564,biological_process +52427,52427,myotube cell development,GO,14904,biological_process +52438,52438,DNA biosynthetic process,GO,71897,biological_process +52532,52532,retinoic acid receptor signaling pathway,GO,48384,biological_process +52555,52555,adipose tissue development,GO,60612,biological_process +52564,52564,"G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger",GO,7187,biological_process +52574,52574,learning or memory,GO,7611,biological_process +52646,52646,astrocyte development,GO,14002,biological_process +52649,52649,positive regulation of prostaglandin biosynthetic process,GO,31394,biological_process +52659,52659,positive regulation of peptidyl-serine phosphorylation,GO,33138,biological_process +52695,52695,autonomic nervous system development,GO,48483,biological_process +52699,52699,visual perception,GO,7601,biological_process +52705,52705,death-inducing signaling complex assembly,GO,71550,biological_process +52712,52712,chondrocyte differentiation,GO,2062,biological_process +52735,52735,response to amphetamine,GO,1975,biological_process +52739,52739,positive regulation of Notch signaling pathway,GO,45747,biological_process +52751,52751,transforming growth factor beta receptor signaling pathway involved in heart development,GO,1905313,biological_process +52771,52771,astrocyte differentiation,GO,48708,biological_process +52812,52812,negative regulation of MAP kinase activity,GO,43407,biological_process +52839,52839,B cell homeostasis,GO,1782,biological_process +52843,52843,mesoderm formation,GO,1707,biological_process +52854,52854,respiratory system development,GO,60541,biological_process +52893,52893,positive regulation of apoptotic cell clearance,GO,2000427,biological_process +52926,52926,negative regulation of cytosolic calcium ion concentration,GO,51481,biological_process +52932,52932,ventricular septum development,GO,3281,biological_process +52947,52947,embryonic digestive tract development,GO,48566,biological_process +52948,52948,stem cell proliferation,GO,72089,biological_process +53042,53042,positive regulation of T cell differentiation in thymus,GO,33089,biological_process +53047,53047,negative regulation of interleukin-17 production,GO,32700,biological_process +53053,53053,response to X-ray,GO,10165,biological_process +53071,53071,adenylate cyclase-modulating G protein-coupled receptor signaling pathway,GO,7188,biological_process +53078,53078,erythrocyte differentiation,GO,30218,biological_process +53092,53092,adherens junction maintenance,GO,34334,biological_process +53130,53130,neuroinflammatory response,GO,150076,biological_process +53169,53169,activation of MAPKKK activity,GO,185,biological_process +53185,53185,methionine biosynthetic process,GO,9086,biological_process +53213,53213,sensory perception of pain,GO,19233,biological_process +53221,53221,positive regulation of dendritic cell chemotaxis,GO,2000510,biological_process +53249,53249,"phagocytosis, engulfment",GO,6911,biological_process +53264,53264,DNA methylation involved in embryo development,GO,43045,biological_process +53268,53268,negative regulation of smooth muscle cell apoptotic process,GO,34392,biological_process +53284,53284,microglial cell activation,GO,1774,biological_process +53285,53285,macrophage activation involved in immune response,GO,2281,biological_process +53286,53286,negative regulation of fat cell differentiation,GO,45599,biological_process +53288,53288,acute-phase response,GO,6953,biological_process +53314,53314,chondrocyte development,GO,2063,biological_process +53320,53320,myoblast proliferation,GO,51450,biological_process +53379,53379,negative regulation of viral genome replication,GO,45071,biological_process +53389,53389,eating behavior,GO,42755,biological_process +53394,53394,phosphatidylinositol-mediated signaling,GO,48015,biological_process +53396,53396,Rho protein signal transduction,GO,7266,biological_process +53407,53407,mRNA stabilization,GO,48255,biological_process +53419,53419,activation of cysteine-type endopeptidase activity involved in apoptotic process,GO,6919,biological_process +53458,53458,growth hormone receptor signaling pathway,GO,60396,biological_process +53470,53470,positive regulation of G2/M transition of mitotic cell cycle,GO,10971,biological_process +53473,53473,macroautophagy,GO,16236,biological_process +53507,53507,phagocytosis,GO,6909,biological_process +53517,53517,methyltransferase activity,GO,8168,molecular_function +53528,53528,protein serine/threonine kinase activity,GO,4674,molecular_function +53551,53551,carboxylic acid transmembrane transporter activity,GO,46943,molecular_function +53562,53562,anion:anion antiporter activity,GO,15301,molecular_function +53616,53616,efflux transmembrane transporter activity,GO,15562,molecular_function +53620,53620,metal ion binding,GO,46872,molecular_function +53627,53627,acetyltransferase activity,GO,16407,molecular_function +53635,53635,ATPase-coupled transmembrane transporter activity,GO,42626,molecular_function +53637,53637,bicarbonate transmembrane transporter activity,GO,15106,molecular_function +53638,53638,symporter activity,GO,15293,molecular_function +53643,53643,sulfate transmembrane transporter activity,GO,15116,molecular_function +53651,53651,quaternary ammonium group transmembrane transporter activity,GO,15651,molecular_function +53662,53662,ABC-type xenobiotic transporter activity,GO,8559,molecular_function +53699,53699,protein binding,GO,5515,molecular_function +53700,53700,protein domain specific binding,GO,19904,molecular_function +53703,53703,proteoglycan binding,GO,43394,molecular_function +53704,53704,G protein-coupled receptor activity,GO,4930,molecular_function +53714,53714,bile acid receptor activity,GO,38181,molecular_function +53722,53722,amino acid transmembrane transporter activity,GO,15171,molecular_function +53726,53726,xenobiotic transmembrane transporter activity,GO,42910,molecular_function +53730,53730,prostaglandin receptor activity,GO,4955,molecular_function +53734,53734,cytokine binding,GO,19955,molecular_function +53756,53756,NADP binding,GO,50661,molecular_function +53767,53767,phosphatidylinositol phosphate binding,GO,1901981,molecular_function +53768,53768,nucleotide binding,GO,166,molecular_function +53775,53775,modified amino acid binding,GO,72341,molecular_function +53818,53818,bile acid binding,GO,32052,molecular_function +53827,53827,cytokine receptor binding,GO,5126,molecular_function +53847,53847,G protein-coupled receptor binding,GO,1664,molecular_function +53848,53848,peptide hormone receptor binding,GO,51428,molecular_function +53856,53856,kinase activity,GO,16301,molecular_function +53861,53861,lipid kinase activity,GO,1727,molecular_function +53866,53866,cation:cation antiporter activity,GO,15491,molecular_function +53876,53876,protein-containing complex binding,GO,44877,molecular_function +53878,53878,actin binding,GO,3779,molecular_function +53881,53881,signaling receptor binding,GO,5102,molecular_function +53882,53882,cell adhesion molecule binding,GO,50839,molecular_function +53883,53883,chromatin binding,GO,3682,molecular_function +53889,53889,protein tyrosine phosphatase activity,GO,4725,molecular_function +53890,53890,protein serine/threonine phosphatase activity,GO,4722,molecular_function +53920,53920,transmembrane signaling receptor activity,GO,4888,molecular_function +53934,53934,carnitine transmembrane transporter activity,GO,15226,molecular_function +53938,53938,protein kinase activity,GO,4672,molecular_function +53957,53957,drug binding,GO,8144,molecular_function +53958,53958,lipid binding,GO,8289,molecular_function +53960,53960,fatty acid binding,GO,5504,molecular_function +53992,53992,ATPase,GO,16887,molecular_function +53993,53993,fucosyltransferase activity,GO,8417,molecular_function +54005,54005,protein kinase binding,GO,19901,molecular_function +54006,54006,protein kinase A binding,GO,51018,molecular_function +54015,54015,RNA polymerase II-specific DNA-binding transcription factor binding,GO,61629,molecular_function +54024,54024,antigen binding,GO,3823,molecular_function +54035,54035,interleukin-1 binding,GO,19966,molecular_function +54040,54040,peptidase activity,GO,8233,molecular_function +54044,54044,cytokine activity,GO,5125,molecular_function +54048,54048,cadherin binding,GO,45296,molecular_function +54093,54093,cadmium ion transmembrane transporter activity,GO,15086,molecular_function +54096,54096,manganese ion transmembrane transporter activity,GO,5384,molecular_function +54097,54097,transition metal ion transmembrane transporter activity,GO,46915,molecular_function +54112,54112,cargo receptor activity,GO,38024,molecular_function +54148,54148,CCR chemokine receptor binding,GO,48020,molecular_function +54149,54149,polysaccharide binding,GO,30247,molecular_function +54175,54175,sequence-specific double-stranded DNA binding,GO,1990837,molecular_function +54186,54186,phosphatidylinositol 3-kinase binding,GO,43548,molecular_function +54190,54190,"alpha-(1,2)-fucosyltransferase activity",GO,31127,molecular_function +54222,54222,metallopeptidase activity,GO,8237,molecular_function +54223,54223,endopeptidase activity,GO,4175,molecular_function +54234,54234,peptide binding,GO,42277,molecular_function +54276,54276,zinc ion binding,GO,8270,molecular_function +54279,54279,calcium ion binding,GO,5509,molecular_function +54288,54288,transcription cis-regulatory region binding,GO,976,molecular_function +54290,54290,enzyme binding,GO,19899,molecular_function +54299,54299,structural molecule activity,GO,5198,molecular_function +54307,54307,collagen binding,GO,5518,molecular_function +54308,54308,laminin binding,GO,43236,molecular_function +54309,54309,integrin binding,GO,5178,molecular_function +54315,54315,secondary active sulfate transmembrane transporter activity,GO,8271,molecular_function +54332,54332,DNA-binding transcription factor activity,GO,3700,molecular_function +54339,54339,transmembrane receptor protein tyrosine kinase activity,GO,4714,molecular_function +54343,54343,interleukin-1 receptor activity,GO,4908,molecular_function +54344,54344,transmembrane transporter activity,GO,22857,molecular_function +54365,54365,molecular adaptor activity,GO,60090,molecular_function +54367,54367,double-stranded DNA binding,GO,3690,molecular_function +54385,54385,"DNA-binding transcription factor activity, RNA polymerase II-specific",GO,981,molecular_function +54387,54387,signaling receptor activity,GO,38023,molecular_function +54389,54389,DNA-binding transcription repressor activity,GO,1217,molecular_function +54392,54392,CXCR chemokine receptor binding,GO,45236,molecular_function +54396,54396,general transcription initiation factor binding,GO,140296,molecular_function +54420,54420,hormone activity,GO,5179,molecular_function +54435,54435,complement receptor activity,GO,4875,molecular_function +54440,54440,C-X-C chemokine receptor activity,GO,16494,molecular_function +54484,54484,DNA binding,GO,3677,molecular_function +54495,54495,peroxidase activity,GO,4601,molecular_function +54502,54502,extracellular matrix structural constituent,GO,5201,molecular_function +54507,54507,transcription factor binding,GO,8134,molecular_function +54535,54535,histone binding,GO,42393,molecular_function +54536,54536,chromatin DNA binding,GO,31490,molecular_function +54576,54576,death domain binding,GO,70513,molecular_function +54578,54578,transcription corepressor activity,GO,3714,molecular_function +54581,54581,GTPase activity,GO,3924,molecular_function +54588,54588,RNA polymerase II cis-regulatory region sequence-specific DNA binding,GO,978,molecular_function +54591,54591,microtubule motor activity,GO,3777,molecular_function +54593,54593,cysteine-type endopeptidase activity,GO,4197,molecular_function +54599,54599,sequence-specific DNA binding,GO,43565,molecular_function +54621,54621,cytokine receptor activity,GO,4896,molecular_function +54629,54629,nuclear receptor binding,GO,16922,molecular_function +54663,54663,RNA polymerase II transcription regulatory region sequence-specific DNA binding,GO,977,molecular_function +54669,54669,metal ion:proton antiporter activity,GO,51139,molecular_function +54671,54671,protease binding,GO,2020,molecular_function +54686,54686,structural constituent of cytoskeleton,GO,5200,molecular_function +54692,54692,superoxide-generating NAD(P)H oxidase activity,GO,16175,molecular_function +54700,54700,heat shock protein binding,GO,31072,molecular_function +54726,54726,MAP kinase kinase activity,GO,4708,molecular_function +54735,54735,aminopeptidase activity,GO,4177,molecular_function +54743,54743,ubiquitin binding,GO,43130,molecular_function +54758,54758,C-C chemokine binding,GO,19957,molecular_function +54761,54761,protein tyrosine kinase activity,GO,4713,molecular_function +54762,54762,adenylate cyclase activity,GO,4016,molecular_function +54763,54763,protein phosphatase binding,GO,19903,molecular_function +54781,54781,protein tyrosine kinase activator activity,GO,30296,molecular_function +54798,54798,methylenetetrahydrofolate reductase (NAD(P)H) activity,GO,4489,molecular_function +54821,54821,flavin adenine dinucleotide binding,GO,50660,molecular_function +54829,54829,pattern recognition receptor activity,GO,38187,molecular_function +54835,54835,microtubule binding,GO,8017,molecular_function +54866,54866,floppase activity,GO,140328,molecular_function +54886,54886,aspartic-type endopeptidase activity,GO,4190,molecular_function +54899,54899,glucocorticoid receptor binding,GO,35259,molecular_function +54902,54902,clathrin binding,GO,30276,molecular_function +54909,54909,cyclin-dependent protein serine/threonine kinase regulator activity,GO,16538,molecular_function +54940,54940,signaling receptor complex adaptor activity,GO,30159,molecular_function +54941,54941,receptor tyrosine kinase binding,GO,30971,molecular_function +54949,54949,peptidase activator activity,GO,16504,molecular_function +54959,54959,cis-regulatory region sequence-specific DNA binding,GO,987,molecular_function +54962,54962,death receptor binding,GO,5123,molecular_function +54973,54973,(R)-carnitine transmembrane transporter activity,GO,1901235,molecular_function +54979,54979,iron ion binding,GO,5506,molecular_function +55000,55000,GTPase activator activity,GO,5096,molecular_function +55006,55006,protein serine/threonine kinase activator activity,GO,43539,molecular_function +55029,55029,interleukin-8 receptor binding,GO,5153,molecular_function +55032,55032,actinin binding,GO,42805,molecular_function +55049,55049,syntaxin binding,GO,19905,molecular_function +55055,55055,transforming growth factor beta receptor binding,GO,5160,molecular_function +55065,55065,steroid hormone receptor activity,GO,3707,molecular_function +55081,55081,C-C chemokine receptor activity,GO,16493,molecular_function +55082,55082,transporter activity,GO,5215,molecular_function +55093,55093,cysteine-type endopeptidase activity involved in apoptotic process,GO,97153,molecular_function +55100,55100,interleukin-17 receptor activity,GO,30368,molecular_function +55136,55136,iron ion transmembrane transporter activity,GO,5381,molecular_function +55157,55157,DNA (cytosine-5-)-methyltransferase activity,GO,3886,molecular_function +55163,55163,ATP-dependent microtubule motor activity,GO,1990939,molecular_function +55196,55196,chemokine receptor activity,GO,4950,molecular_function +55237,55237,phosphatase binding,GO,19902,molecular_function +55266,55266,protein self-association,GO,43621,molecular_function +55268,55268,interleukin-1 receptor binding,GO,5149,molecular_function +55276,55276,cysteine-type endopeptidase inhibitor activity,GO,4869,molecular_function +55307,55307,alpha-actinin binding,GO,51393,molecular_function +55312,55312,non-membrane spanning protein tyrosine kinase activity,GO,4715,molecular_function +55320,55320,SUMO binding,GO,32183,molecular_function +55325,55325,metalloendopeptidase activity,GO,4222,molecular_function +55347,55347,DNA-binding transcription factor binding,GO,140297,molecular_function +55373,55373,tubulin binding,GO,15631,molecular_function +55389,55389,calcium-dependent protein binding,GO,48306,molecular_function +55436,55436,identical protein binding,GO,42802,molecular_function +55437,55437,protein dimerization activity,GO,46983,molecular_function +55482,55482,ubiquitin protein ligase activity,GO,61630,molecular_function +55497,55497,bHLH transcription factor binding,GO,43425,molecular_function +55500,55500,GTPase binding,GO,51020,molecular_function +55504,55504,actin filament binding,GO,51015,molecular_function +55512,55512,SNARE binding,GO,149,molecular_function +55514,55514,protein N-terminus binding,GO,47485,molecular_function +55517,55517,transport vesicle,GO,30133,cellular_component +55522,55522,integral component of membrane,GO,16021,cellular_component +55534,55534,cytoplasmic vesicle,GO,31410,cellular_component +55537,55537,inclusion body,GO,16234,cellular_component +55538,55538,intracellular membrane-bounded organelle,GO,43231,cellular_component +55573,55573,receptor complex,GO,43235,cellular_component +55581,55581,collagen trimer,GO,5581,cellular_component +55599,55599,RNA polymerase II transcription regulator complex,GO,90575,cellular_component +55601,55601,SMAD protein complex,GO,71141,cellular_component +55634,55634,vesicle,GO,31982,cellular_component +55635,55635,protein-containing complex,GO,32991,cellular_component +55647,55647,early endosome membrane,GO,31901,cellular_component +55649,55649,cell projection,GO,42995,cellular_component +55651,55651,endosome lumen,GO,31904,cellular_component +55657,55657,late endosome membrane,GO,31902,cellular_component +55662,55662,microvillus,GO,5902,cellular_component +55663,55663,ribonucleoprotein complex,GO,1990904,cellular_component +55675,55675,transcription regulator complex,GO,5667,cellular_component +55725,55725,membrane,GO,16020,cellular_component +55726,55726,intrinsic component of plasma membrane,GO,31226,cellular_component +55734,55734,kinesin complex,GO,5871,cellular_component +55741,55741,laminin complex,GO,43256,cellular_component +55754,55754,synapse,GO,45202,cellular_component +55757,55757,glutamatergic synapse,GO,98978,cellular_component +55760,55760,anchored component of plasma membrane,GO,46658,cellular_component +55767,55767,endoplasmic reticulum membrane,GO,5789,cellular_component +55770,55770,terminal bouton,GO,43195,cellular_component +55773,55773,endosome,GO,5768,cellular_component +55774,55774,lysosome,GO,5764,cellular_component +55775,55775,chaperone complex,GO,101031,cellular_component +55782,55782,Golgi-associated vesicle,GO,5798,cellular_component +55783,55783,clathrin-coated vesicle,GO,30136,cellular_component +55791,55791,phagocytic vesicle lumen,GO,97013,cellular_component +55806,55806,autophagosome,GO,5776,cellular_component +55807,55807,phagocytic vesicle,GO,45335,cellular_component +55831,55831,axon,GO,30424,cellular_component +55840,55840,microtubule,GO,5874,cellular_component +55842,55842,integral component of plasma membrane,GO,5887,cellular_component +55850,55850,cytoplasmic ribonucleoprotein granule,GO,36464,cellular_component +55851,55851,membrane raft,GO,45121,cellular_component +55888,55888,mitochondrial membrane,GO,31966,cellular_component +55898,55898,neuron projection,GO,43005,cellular_component +55901,55901,lamellipodium,GO,30027,cellular_component +55902,55902,filopodium,GO,30175,cellular_component +55905,55905,presynapse,GO,98793,cellular_component +55925,55925,dendrite,GO,30425,cellular_component +55943,55943,heterochromatin,GO,792,cellular_component +55951,55951,secretory granule membrane,GO,30667,cellular_component +55952,55952,lysosomal membrane,GO,5765,cellular_component +55959,55959,actin cytoskeleton,GO,15629,cellular_component +55971,55971,endosome membrane,GO,10008,cellular_component +55974,55974,integrin complex,GO,8305,cellular_component +55980,55980,secretory granule lumen,GO,34774,cellular_component +55981,55981,secretory granule,GO,30141,cellular_component +55983,55983,exocytic vesicle,GO,70382,cellular_component +55992,55992,extracellular matrix,GO,31012,cellular_component +56014,56014,insulin-like growth factor binding protein complex,GO,16942,cellular_component +56028,56028,adherens junction,GO,5912,cellular_component +56032,56032,endoplasmic reticulum,GO,5783,cellular_component +56034,56034,late endosome,GO,5770,cellular_component +56048,56048,autophagosome membrane,GO,421,cellular_component +56049,56049,phagocytic vesicle membrane,GO,30670,cellular_component +56052,56052,transport vesicle membrane,GO,30658,cellular_component +56063,56063,intermediate filament,GO,5882,cellular_component +56073,56073,nucleus,GO,5634,cellular_component +56075,56075,Golgi lumen,GO,5796,cellular_component +56085,56085,growth cone,GO,30426,cellular_component +56095,56095,death-inducing signaling complex,GO,31264,cellular_component +56099,56099,collagen-containing extracellular matrix,GO,62023,cellular_component +56101,56101,recycling endosome,GO,55037,cellular_component +56107,56107,nuclear speck,GO,16607,cellular_component +56112,56112,endocytic vesicle,GO,30139,cellular_component +56113,56113,clathrin-coated endocytic vesicle membrane,GO,30669,cellular_component +56117,56117,endoplasmic reticulum lumen,GO,5788,cellular_component +56150,56150,blood microparticle,GO,72562,cellular_component +56152,56152,cell junction,GO,30054,cellular_component +56156,56156,postsynapse,GO,98794,cellular_component +56160,56160,cytoskeleton,GO,5856,cellular_component +56173,56173,chromatin,GO,785,cellular_component +56174,56174,extracellular region,GO,5576,cellular_component +56175,56175,Golgi apparatus,GO,5794,cellular_component +56207,56207,nuclear body,GO,16604,cellular_component +56214,56214,cytoplasmic side of plasma membrane,GO,9898,cellular_component +56223,56223,perinuclear region of cytoplasm,GO,48471,cellular_component +56226,56226,endocytic vesicle membrane,GO,30666,cellular_component +56241,56241,cytoplasm,GO,5737,cellular_component +56263,56263,plasma membrane,GO,5886,cellular_component +56272,56272,late endosome lumen,GO,31906,cellular_component +56275,56275,Golgi cisterna membrane,GO,32580,cellular_component +56278,56278,pericentric heterochromatin,GO,5721,cellular_component +56282,56282,beta-catenin-TCF complex,GO,1990907,cellular_component +56319,56319,early endosome,GO,5769,cellular_component +56322,56322,external side of plasma membrane,GO,9897,cellular_component +56413,56413,dendrite cytoplasm,GO,32839,cellular_component +56424,56424,plasma membrane raft,GO,44853,cellular_component +56432,56432,Golgi membrane,GO,139,cellular_component +56436,56436,cytosol,GO,5829,cellular_component +56449,56449,postsynaptic density,GO,14069,cellular_component +56459,56459,phagolysosome,GO,32010,cellular_component +56460,56460,cortical actin cytoskeleton,GO,30864,cellular_component +56475,56475,"chromosome, centromeric region",GO,775,cellular_component +63112,63112,uterine cervix,UBERON,2,anatomy +63116,63116,islet of Langerhans,UBERON,6,anatomy +63117,63117,pituitary gland,UBERON,7,anatomy +63123,63123,zone of skin,UBERON,14,anatomy +63136,63136,lymph node,UBERON,29,anatomy +63148,63148,tendon,UBERON,43,anatomy +63149,63149,dorsal root ganglion,UBERON,44,anatomy +63164,63164,large intestine,UBERON,59,anatomy +63173,63173,renal glomerulus,UBERON,74,anatomy +63180,63180,metanephros,UBERON,81,anatomy +63181,63181,adult mammalian kidney,UBERON,82,anatomy +63223,63223,intestine,UBERON,160,anatomy +63235,63235,amniotic fluid,UBERON,173,anatomy +63240,63240,blood,UBERON,178,anatomy +63273,63273,colonic mucosa,UBERON,317,anatomy +63359,63359,prefrontal cortex,UBERON,451,anatomy +63370,63370,material anatomical entity,UBERON,465,anatomy +63372,63372,anatomical system,UBERON,467,anatomy +63376,63376,testis,UBERON,473,anatomy +63377,63377,female reproductive system,UBERON,474,anatomy +63407,63407,embryo,UBERON,922,anatomy +63423,63423,stomach,UBERON,945,anatomy +63425,63425,aorta,UBERON,947,anatomy +63426,63426,heart,UBERON,948,anatomy +63430,63430,brain,UBERON,955,anatomy +63431,63431,cerebral cortex,UBERON,956,anatomy +63441,63441,eye,UBERON,970,anatomy +63464,63464,uterus,UBERON,995,anatomy +63465,63465,vagina,UBERON,996,anatomy +63466,63466,mammalian vulva,UBERON,997,anatomy +63481,63481,adipose tissue,UBERON,1013,anatomy +63484,63484,central nervous system,UBERON,1017,anatomy +63488,63488,nerve,UBERON,1021,anatomy +63500,63500,esophagus,UBERON,1043,anatomy +63501,63501,saliva-secreting gland,UBERON,1044,anatomy +63584,63584,skeletal muscle tissue,UBERON,1134,anatomy +63585,63585,smooth muscle tissue,UBERON,1135,anatomy +63602,63602,caecum,UBERON,1153,anatomy +63603,63603,vermiform appendix,UBERON,1154,anatomy +63604,63604,colon,UBERON,1155,anatomy +63608,63608,sigmoid colon,UBERON,1159,anatomy +63609,63609,fundus of stomach,UBERON,1160,anatomy +63674,63674,cortex of kidney,UBERON,1225,anatomy +63680,63680,nephron tubule,UBERON,1231,anatomy +63684,63684,adrenal cortex,UBERON,1235,anatomy +63704,63704,urinary bladder,UBERON,1255,anatomy +63713,63713,pancreas,UBERON,1264,anatomy +63744,63744,endometrium,UBERON,1295,anatomy +63745,63745,myometrium,UBERON,1296,anatomy +63772,63772,tibial nerve,UBERON,1323,anatomy +63824,63824,quadriceps femoris,UBERON,1377,anatomy +63826,63826,vastus lateralis,UBERON,1379,anatomy +63830,63830,muscle of leg,UBERON,1383,anatomy +63920,63920,bone element,UBERON,1474,anatomy +63921,63921,deltoid,UBERON,1476,anatomy +63952,63952,biceps brachii,UBERON,1507,anatomy +64065,64065,coronary artery,UBERON,1621,anatomy +64074,64074,muscle organ,UBERON,1630,anatomy +64081,64081,artery,UBERON,1637,anatomy +64165,64165,tongue,UBERON,1723,anatomy +64170,64170,nasopharynx,UBERON,1728,anatomy +64253,64253,palpebral conjunctiva,UBERON,1812,anatomy +64258,64258,lacrimal gland,UBERON,1817,anatomy +64267,64267,nasal cavity mucosa,UBERON,1826,anatomy +64269,64269,gingiva,UBERON,1828,anatomy +64311,64311,frontal cortex,UBERON,1870,anatomy +64312,64312,temporal lobe,UBERON,1871,anatomy +64313,64313,parietal lobe,UBERON,1872,anatomy +64314,64314,caudate nucleus,UBERON,1873,anatomy +64315,64315,putamen,UBERON,1874,anatomy +64316,64316,globus pallidus,UBERON,1875,anatomy +64317,64317,amygdala,UBERON,1876,anatomy +64323,64323,nucleus accumbens,UBERON,1882,anatomy +64331,64331,forebrain,UBERON,1890,anatomy +64332,64332,midbrain,UBERON,1891,anatomy +64334,64334,telencephalon,UBERON,1893,anatomy +64337,64337,medulla oblongata,UBERON,1896,anatomy +64338,64338,dorsal plus ventral thalamus,UBERON,1897,anatomy +64339,64339,hypothalamus,UBERON,1898,anatomy +64352,64352,mammary gland,UBERON,1911,anatomy +64391,64391,neocortex,UBERON,1950,anatomy +64395,64395,Ammon's horn,UBERON,1954,anatomy +64416,64416,epithelium of esophagus,UBERON,1976,anatomy +64427,64427,placenta,UBERON,1987,anatomy +64460,64460,occipital lobe,UBERON,2021,anatomy +64470,64470,epithelium of bronchus,UBERON,2031,anatomy +64476,64476,cerebellum,UBERON,2037,anatomy +64477,64477,substantia nigra,UBERON,2038,anatomy +64485,64485,thyroid gland,UBERON,2046,anatomy +64487,64487,lung,UBERON,2048,anatomy +64512,64512,hair follicle,UBERON,2073,anatomy +64520,64520,cardiac atrium,UBERON,2081,anatomy +64521,64521,cardiac ventricle,UBERON,2082,anatomy +64523,64523,heart left ventricle,UBERON,2084,anatomy +64544,64544,spleen,UBERON,2106,anatomy +64545,64545,liver,UBERON,2107,anatomy +64546,64546,small intestine,UBERON,2108,anatomy +64548,64548,gall bladder,UBERON,2110,anatomy +64551,64551,kidney,UBERON,2113,anatomy +64552,64552,duodenum,UBERON,2114,anatomy +64553,64553,jejunum,UBERON,2115,anatomy +64565,64565,cerebellar cortex,UBERON,2129,anatomy +64621,64621,bronchus,UBERON,2185,anatomy +64626,64626,subcutaneous adipose tissue,UBERON,2190,anatomy +64653,64653,synovial joint,UBERON,2217,anatomy +64675,64675,spinal cord,UBERON,2240,anatomy +64680,64680,cerebellar hemisphere,UBERON,2245,anatomy +64766,64766,corpus callosum,UBERON,2336,anatomy +64778,64778,myocardium,UBERON,2349,anatomy +64787,64787,peritoneum,UBERON,2358,anatomy +64796,64796,prostate gland,UBERON,2367,anatomy +64798,64798,adrenal gland,UBERON,2369,anatomy +64799,64799,thymus,UBERON,2370,anatomy +64800,64800,bone marrow,UBERON,2371,anatomy +64801,64801,tonsil,UBERON,2372,anatomy +64813,64813,connective tissue,UBERON,2384,anatomy +64814,64814,muscle tissue,UBERON,2385,anatomy +64846,64846,cartilage tissue,UBERON,2418,anatomy +64863,64863,primary visual cortex,UBERON,2436,anatomy +64876,64876,decidua,UBERON,2450,anatomy +64894,64894,esophagus mucosa,UBERON,2469,anatomy +64902,64902,medial globus pallidus,UBERON,2477,anatomy +65076,65076,superior frontal gyrus,UBERON,2661,anatomy +65138,65138,entorhinal cortex,UBERON,2728,anatomy +65415,65415,cingulate cortex,UBERON,3027,anatomy +65509,65509,trachea,UBERON,3126,anatomy +65557,65557,epithelium of mammary gland,UBERON,3244,anatomy +65990,65990,mouth mucosa,UBERON,3729,anatomy +66050,66050,fallopian tube,UBERON,3889,anatomy +66747,66747,cerebellar vermis,UBERON,4720,anatomy +66760,66760,metanephric glomerulus,UBERON,4736,anatomy +66823,66823,cervix epithelium,UBERON,4801,anatomy +66826,66826,oviduct epithelium,UBERON,4804,anatomy +66841,66841,kidney epithelium,UBERON,4819,anatomy +67143,67143,thoracic mammary gland,UBERON,5200,anatomy +67302,67302,nasal cavity epithelium,UBERON,5384,anatomy +68030,68030,Brodmann (1909) area 46,UBERON,6483,anatomy +68316,68316,squamous epithelium,UBERON,6914,anatomy +68618,68618,layer of synovial tissue,UBERON,7616,anatomy +68729,68729,adipose tissue of abdominal region,UBERON,7808,anatomy +69442,69442,dorsolateral prefrontal cortex,UBERON,9834,anatomy +69443,69443,anterior cingulate cortex,UBERON,9835,anatomy +69864,69864,omental fat pad,UBERON,10414,anatomy +71196,71196,Brodmann (1909) area 9,UBERON,13540,anatomy +71729,71729,skeletal muscle organ,UBERON,14892,anatomy +72147,72147,frontal lobe,UBERON,16525,anatomy +100074,100074,type 2 immune response,GO,42092,biological_process +100078,100078,platelet aggregation,GO,70527,biological_process +100117,100117,forebrain development,GO,30900,biological_process +100118,100118,hair follicle development,GO,1942,biological_process +100120,100120,midbrain development,GO,30901,biological_process +100189,100189,brainstem development,GO,3360,biological_process +100201,100201,maternal placenta development,GO,1893,biological_process +100209,100209,endocrine pancreas development,GO,31018,biological_process +100232,100232,olfactory bulb development,GO,21772,biological_process +100233,100233,hippocampus development,GO,21766,biological_process +100236,100236,medullary reticular formation development,GO,21723,biological_process +100246,100246,striatum development,GO,21756,biological_process +100266,100266,growth hormone secretion,GO,30252,biological_process +100267,100267,glucagon secretion,GO,70091,biological_process +100308,100308,positive regulation of corticotropin secretion,GO,51461,biological_process +100321,100321,positive regulation of cold-induced thermogenesis,GO,120162,biological_process +100325,100325,positive regulation of multicellular organism growth,GO,40018,biological_process +100339,100339,positive regulation of adipose tissue development,GO,1904179,biological_process +100346,100346,positive regulation of mammary gland epithelial cell proliferation,GO,33601,biological_process +100359,100359,positive regulation of renal albumin absorption,GO,2000534,biological_process +100368,100368,positive regulation of bone development,GO,1903012,biological_process +100400,100400,sperm capacitation,GO,48240,biological_process +100416,100416,DNA methylation involved in gamete generation,GO,43046,biological_process +100481,100481,decidualization,GO,46697,biological_process +100514,100514,branching involved in labyrinthine layer morphogenesis,GO,60670,biological_process +100528,100528,spermatogenesis,GO,7283,biological_process +100616,100616,innate immune response in mucosa,GO,2227,biological_process +100617,100617,antifungal innate immune response,GO,61760,biological_process +100623,100623,"complement activation, lectin pathway",GO,1867,biological_process +100699,100699,post-embryonic digestive tract morphogenesis,GO,48621,biological_process +100733,100733,negative regulation of hyaluronan biosynthetic process,GO,1900126,biological_process +100759,100759,cellular response to dexamethasone stimulus,GO,71549,biological_process +100791,100791,negative regulation of platelet-derived growth factor receptor-beta signaling pathway,GO,2000587,biological_process +100924,100924,positive regulation of metanephric glomerular visceral epithelial cell development,GO,2000478,biological_process +100945,100945,negative regulation of osteoblast proliferation,GO,33689,biological_process +100999,100999,I-kappaB phosphorylation,GO,7252,biological_process +101002,101002,common-partner SMAD protein phosphorylation,GO,7182,biological_process +101003,101003,pathway-restricted SMAD protein phosphorylation,GO,60389,biological_process +101019,101019,sebum secreting cell proliferation,GO,1990654,biological_process +101088,101088,positive regulation of SMAD protein signal transduction,GO,60391,biological_process +101089,101089,positive regulation of pathway-restricted SMAD protein phosphorylation,GO,10862,biological_process +101090,101090,positive regulation of podosome assembly,GO,71803,biological_process +101114,101114,positive regulation of NLRP3 inflammasome complex assembly,GO,1900227,biological_process +101135,101135,positive regulation of osteoblast proliferation,GO,33690,biological_process +101140,101140,positive regulation of chondrocyte proliferation,GO,1902732,biological_process +101142,101142,positive regulation of synoviocyte proliferation,GO,1901647,biological_process +101143,101143,positive regulation of trophectodermal cell proliferation,GO,1904075,biological_process +101155,101155,positive regulation of autophagosome maturation,GO,1901098,biological_process +101156,101156,positive regulation of xenophagy,GO,1904417,biological_process +101311,101311,osteoblast development,GO,2076,biological_process +101323,101323,positive regulation of melanin biosynthetic process,GO,48023,biological_process +101327,101327,positive regulation of vitamin D biosynthetic process,GO,60557,biological_process +101330,101330,positive regulation of glycogen biosynthetic process,GO,45725,biological_process +101346,101346,positive regulation of nitric oxide biosynthetic process,GO,45429,biological_process +101352,101352,positive regulation of gluconeogenesis,GO,45722,biological_process +101434,101434,luteolysis,GO,1554,biological_process +101439,101439,ovulation from ovarian follicle,GO,1542,biological_process +101515,101515,cellular response to estradiol stimulus,GO,71392,biological_process +101535,101535,cellular response to cAMP,GO,71320,biological_process +101536,101536,cellular response to staurosporine,GO,72734,biological_process +101539,101539,cellular response to indole-3-methanol,GO,71681,biological_process +101550,101550,cellular response to bile acid,GO,1903413,biological_process +101610,101610,negative regulation of adiponectin secretion,GO,70164,biological_process +101628,101628,negative regulation of amyloid-beta clearance,GO,1900222,biological_process +101649,101649,negative regulation of cold-induced thermogenesis,GO,120163,biological_process +101655,101655,negative regulation of very-low-density lipoprotein particle remodeling,GO,10903,biological_process +101706,101706,negative regulation of B cell proliferation,GO,30889,biological_process +101786,101786,signal transduction involved in regulation of gene expression,GO,23019,biological_process +101790,101790,necroptotic signaling pathway,GO,97527,biological_process +101792,101792,SMAD protein signal transduction,GO,60395,biological_process +101905,101905,membrane hyperpolarization,GO,60081,biological_process +101974,101974,cellular response to retinoic acid,GO,71300,biological_process +101981,101981,cellular response to lipopolysaccharide,GO,71222,biological_process +102172,102172,negative regulation of heterotypic cell-cell adhesion,GO,34115,biological_process +102190,102190,negative regulation of MHC class II biosynthetic process,GO,45347,biological_process +102260,102260,cellular response to nicotine,GO,71316,biological_process +102269,102269,opsonization,GO,8228,biological_process +102345,102345,chloride transmembrane transport,GO,1902476,biological_process +102483,102483,positive regulation of membrane protein ectodomain proteolysis,GO,51044,biological_process +102550,102550,positive regulation of melanosome transport,GO,1902910,biological_process +102607,102607,regulation of respiratory gaseous exchange by nervous system process,GO,2087,biological_process +102651,102651,positive regulation of osteoblast differentiation,GO,45669,biological_process +102660,102660,DNA methylation-dependent heterochromatin assembly,GO,6346,biological_process +102663,102663,neutrophil apoptotic process,GO,1781,biological_process +102684,102684,cellular response to ethanol,GO,71361,biological_process +102690,102690,placenta development,GO,1890,biological_process +102695,102695,brain development,GO,7420,biological_process +102706,102706,amyloid fibril formation,GO,1990000,biological_process +102711,102711,cardiac neuron differentiation,GO,60945,biological_process +102718,102718,nitrite transport,GO,15707,biological_process +102737,102737,positive regulation of chronic inflammatory response to antigenic stimulus,GO,2876,biological_process +102816,102816,cellular response to peptidoglycan,GO,71224,biological_process +102854,102854,vertebrate eye-specific patterning,GO,150064,biological_process +102910,102910,trophoblast giant cell differentiation,GO,60707,biological_process +102956,102956,"positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity",GO,60550,biological_process +102957,102957,positive regulation of alkaline phosphatase activity,GO,10694,biological_process +102970,102970,positive regulation of protein localization to cell surface,GO,2000010,biological_process +103002,103002,transdifferentiation,GO,60290,biological_process +103013,103013,ectodermal cell differentiation,GO,10668,biological_process +103020,103020,endodermal cell differentiation,GO,35987,biological_process +103057,103057,positive regulation of monocyte chemotaxis,GO,90026,biological_process +103164,103164,cellular cadmium ion homeostasis,GO,6876,biological_process +103169,103169,ubiquitin-dependent endocytosis,GO,70086,biological_process +103224,103224,platelet degranulation,GO,2576,biological_process +103240,103240,regulation of protein complex stability,GO,61635,biological_process +103259,103259,somitogenesis,GO,1756,biological_process +103307,103307,platelet formation,GO,30220,biological_process +103352,103352,negative regulation of serine C-palmitoyltransferase activity,GO,1904221,biological_process +103391,103391,ovarian follicle development,GO,1541,biological_process +103433,103433,sphingosine-1-phosphate receptor signaling pathway,GO,3376,biological_process +103444,103444,chaperone-mediated protein complex assembly,GO,51131,biological_process +103465,103465,SMAD protein complex assembly,GO,7183,biological_process +103491,103491,positive regulation of iron ion import across plasma membrane,GO,1904440,biological_process +103506,103506,cellular response to hepatocyte growth factor stimulus,GO,35729,biological_process +103513,103513,negative regulation of MyD88-independent toll-like receptor signaling pathway,GO,34128,biological_process +103643,103643,pituitary gland development,GO,21983,biological_process +103646,103646,adrenal gland development,GO,30325,biological_process +103655,103655,thyroid gland development,GO,30878,biological_process +103678,103678,chronic inflammatory response to antigenic stimulus,GO,2439,biological_process +103686,103686,determination of adult lifespan,GO,8340,biological_process +103688,103688,keratinization,GO,31424,biological_process +103692,103692,response to dietary excess,GO,2021,biological_process +103696,103696,innervation,GO,60384,biological_process +103707,103707,circadian regulation of gene expression,GO,32922,biological_process +103716,103716,positive regulation of interleukin-2 production,GO,32743,biological_process +103717,103717,positive regulation of interleukin-8 production,GO,32757,biological_process +103719,103719,positive regulation of vascular endothelial growth factor production,GO,10575,biological_process +103727,103727,positive regulation of interleukin-18 production,GO,32741,biological_process +103729,103729,positive regulation of interleukin-10 production,GO,32733,biological_process +103730,103730,positive regulation of interleukin-6 production,GO,32755,biological_process +103734,103734,positive regulation of granulocyte macrophage colony-stimulating factor production,GO,32725,biological_process +103737,103737,positive regulation of cytokine production involved in inflammatory response,GO,1900017,biological_process +103741,103741,positive regulation of interleukin-33 production,GO,150129,biological_process +103742,103742,positive regulation of interleukin-23 production,GO,32747,biological_process +103746,103746,positive regulation of interleukin-21 production,GO,32745,biological_process +103747,103747,positive regulation of interleukin-12 production,GO,32735,biological_process +103750,103750,positive regulation of interferon-gamma production,GO,32729,biological_process +103754,103754,positive regulation of interleukin-4 production,GO,32753,biological_process +103773,103773,negative regulation of vascular endothelial growth factor signaling pathway,GO,1900747,biological_process +103809,103809,negative regulation of nitric oxide biosynthetic process,GO,45019,biological_process +103845,103845,negative regulation of hydrogen peroxide biosynthetic process,GO,10730,biological_process +103856,103856,negative regulation of gluconeogenesis,GO,45721,biological_process +103878,103878,cAMP biosynthetic process,GO,6171,biological_process +103923,103923,positive regulation of NAD+ ADP-ribosyltransferase activity,GO,1901666,biological_process +103924,103924,positive regulation of glycogen (starch) synthase activity,GO,2000467,biological_process +103971,103971,ERK1 and ERK2 cascade,GO,70371,biological_process +104021,104021,sodium-dependent organic cation transport,GO,70715,biological_process +104050,104050,bicarbonate transport,GO,15701,biological_process +104082,104082,cellular response to lipoteichoic acid,GO,71223,biological_process +104124,104124,Wnt signalosome assembly,GO,1904887,biological_process +104127,104127,integrin activation,GO,33622,biological_process +104150,104150,beta-catenin-TCF complex assembly,GO,1904837,biological_process +104156,104156,positive regulation of low-density lipoprotein receptor activity,GO,1905599,biological_process +104166,104166,female pregnancy,GO,7565,biological_process +104220,104220,renal water homeostasis,GO,3091,biological_process +104232,104232,positive regulation of activation of Janus kinase activity,GO,10536,biological_process +104355,104355,cell redox homeostasis,GO,45454,biological_process +104454,104454,negative regulation of osteoblast differentiation,GO,45668,biological_process +104460,104460,negative regulation of macrophage derived foam cell differentiation,GO,10745,biological_process +104471,104471,xenobiotic detoxification by transmembrane export across the plasma membrane,GO,1990961,biological_process +104480,104480,negative regulation of GTPase activity,GO,34260,biological_process +104604,104604,intracellular bile acid receptor signaling pathway,GO,38185,biological_process +104608,104608,peroxisome proliferator activated receptor signaling pathway,GO,35357,biological_process +104611,104611,positive regulation of monophenol monooxygenase activity,GO,32773,biological_process +104613,104613,positive regulation of calcidiol 1-monooxygenase activity,GO,60559,biological_process +104615,104615,positive regulation of nitric-oxide synthase activity,GO,51000,biological_process +104646,104646,C-5 methylation of cytosine,GO,90116,biological_process +104704,104704,positive regulation of translational initiation by iron,GO,45994,biological_process +104741,104741,activation of JNKK activity,GO,7256,biological_process +104760,104760,immune system development,GO,2520,biological_process +104764,104764,enteric nervous system development,GO,48484,biological_process +104767,104767,parasympathetic nervous system development,GO,48486,biological_process +104771,104771,sympathetic nervous system development,GO,48485,biological_process +104775,104775,nervous system development,GO,7399,biological_process +104777,104777,positive regulation of platelet activation,GO,10572,biological_process +104781,104781,cellular response to glucose stimulus,GO,71333,biological_process +104846,104846,positive regulation of peroxisome proliferator activated receptor signaling pathway,GO,35360,biological_process +104849,104849,positive regulation of insulin-like growth factor receptor signaling pathway,GO,43568,biological_process +104873,104873,positive regulation of vascular endothelial growth factor receptor signaling pathway,GO,30949,biological_process +104878,104878,positive regulation of growth hormone receptor signaling pathway,GO,60399,biological_process +104896,104896,negative regulation of low-density lipoprotein receptor activity,GO,1905598,biological_process +104980,104980,positive regulation of NMDA glutamate receptor activity,GO,1904783,biological_process +105078,105078,negative regulation of autophagosome assembly,GO,1902902,biological_process +105130,105130,cellular response to cadmium ion,GO,71276,biological_process +105138,105138,cellular response to lithium ion,GO,71285,biological_process +105148,105148,cellular response to glucagon stimulus,GO,71377,biological_process +105152,105152,cellular response to angiotensin,GO,1904385,biological_process +105155,105155,cellular response to insulin stimulus,GO,32869,biological_process +105209,105209,positive regulation of fat cell apoptotic process,GO,1904651,biological_process +105242,105242,cellular response to transforming growth factor beta stimulus,GO,71560,biological_process +105245,105245,cellular response to vascular endothelial growth factor stimulus,GO,35924,biological_process +105246,105246,cellular response to fibroblast growth factor stimulus,GO,44344,biological_process +105247,105247,cellular response to BMP stimulus,GO,71773,biological_process +105254,105254,cell surface bile acid receptor signaling pathway,GO,38184,biological_process +105255,105255,integrin-mediated signaling pathway,GO,7229,biological_process +105260,105260,lipopolysaccharide-mediated signaling pathway,GO,31663,biological_process +105262,105262,negative regulation of amyloid-beta formation,GO,1902430,biological_process +105279,105279,negative regulation of cell adhesion molecule production,GO,60354,biological_process +105291,105291,collagen catabolic process,GO,30574,biological_process +105410,105410,embryonic foregut morphogenesis,GO,48617,biological_process +105439,105439,lens fiber cell differentiation,GO,70306,biological_process +105443,105443,hepatocyte differentiation,GO,70365,biological_process +105525,105525,negative regulation of NIK/NF-kappaB signaling,GO,1901223,biological_process +105527,105527,negative regulation of protein kinase B signaling,GO,51898,biological_process +105531,105531,positive regulation of growth hormone secretion,GO,60124,biological_process +105677,105677,negative regulation of release of cytochrome c from mitochondria,GO,90201,biological_process +105699,105699,cellular triglyceride homeostasis,GO,35356,biological_process +105701,105701,cellular sphingolipid homeostasis,GO,90156,biological_process +105720,105720,negative regulation of oocyte development,GO,60283,biological_process +105730,105730,T-helper 17 type immune response,GO,72538,biological_process +105731,105731,T-helper 1 type immune response,GO,42088,biological_process +105732,105732,primary adaptive immune response involving T cells and B cells,GO,90721,biological_process +105742,105742,"regulation of protein catabolic process at postsynapse, modulating synaptic transmission",GO,99576,biological_process +105784,105784,monocyte differentiation,GO,30224,biological_process +105794,105794,neural tube development,GO,21915,biological_process +105795,105795,pericardium development,GO,60039,biological_process +105802,105802,mammary gland epithelium development,GO,61180,biological_process +105808,105808,negative regulation of ATPase-coupled calcium transmembrane transporter activity,GO,1901895,biological_process +105886,105886,positive regulation of exosomal secretion,GO,1903543,biological_process +105889,105889,positive regulation of small intestinal transit,GO,120058,biological_process +105906,105906,execution phase of apoptosis,GO,97194,biological_process +105917,105917,negative regulation of osteoclast development,GO,2001205,biological_process +105918,105918,positive regulation of protein import into nucleus,GO,42307,biological_process +105930,105930,neuronal-glial interaction involved in cerebral cortex radial glia guided migration,GO,21812,biological_process +105932,105932,cell-cell adhesion in response to extracellular stimulus,GO,140039,biological_process +105973,105973,positive regulation of cellular response to macrophage colony-stimulating factor stimulus,GO,1903974,biological_process +105978,105978,positive regulation of cell adhesion molecule production,GO,60355,biological_process +105980,105980,cellular response to interferon-beta,GO,35458,biological_process +106007,106007,negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis,GO,1903588,biological_process +106008,106008,negative regulation of vascular endothelial cell proliferation,GO,1905563,biological_process +106055,106055,histone H2A-S139 phosphorylation,GO,35978,biological_process +106057,106057,cholesterol homeostasis,GO,42632,biological_process +106079,106079,T cell antigen processing and presentation,GO,2457,biological_process +106089,106089,cellular response to leptin stimulus,GO,44320,biological_process +106126,106126,negative regulation of interferon-gamma production,GO,32689,biological_process +106128,106128,negative regulation of interleukin-6 production,GO,32715,biological_process +106130,106130,negative regulation of interleukin-10 production,GO,32693,biological_process +106135,106135,negative regulation of interleukin-23 production,GO,32707,biological_process +106138,106138,negative regulation of cytokine production involved in inflammatory response,GO,1900016,biological_process +106145,106145,negative regulation of interleukin-8 production,GO,32717,biological_process +106148,106148,negative regulation of interleukin-2 production,GO,32703,biological_process +106160,106160,negative regulation of interleukin-12 production,GO,32695,biological_process +106161,106161,negative regulation of interleukin-18 production,GO,32701,biological_process +106165,106165,positive regulation of tyrosine phosphorylation of STAT protein,GO,42531,biological_process +106167,106167,eosinophil chemotaxis,GO,48245,biological_process +106173,106173,cadmium ion transmembrane transport,GO,70574,biological_process +106194,106194,cellular response to mechanical stimulus,GO,71260,biological_process +106197,106197,positive regulation of ATP biosynthetic process,GO,2001171,biological_process +106253,106253,positive regulation of protein kinase A signaling,GO,10739,biological_process +106254,106254,positive regulation of NIK/NF-kappaB signaling,GO,1901224,biological_process +106257,106257,positive regulation of phosphatidylinositol 3-kinase signaling,GO,14068,biological_process +106260,106260,positive regulation of protein kinase B signaling,GO,51897,biological_process +106283,106283,negative regulation of sensory perception of pain,GO,1904057,biological_process +106319,106319,calcium-mediated signaling using intracellular calcium source,GO,35584,biological_process +106320,106320,CAMKK-AMPK signaling cascade,GO,61762,biological_process +106327,106327,positive regulation of matrix metallopeptidase secretion,GO,1904466,biological_process +106339,106339,negative regulation of primary miRNA processing,GO,2000635,biological_process +106389,106389,positive regulation of amyloid-beta formation,GO,1902004,biological_process +106403,106403,negative regulation of toll-like receptor 2 signaling pathway,GO,34136,biological_process +106434,106434,cortisol secretion,GO,43400,biological_process +106451,106451,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand,GO,2001240,biological_process +106452,106452,positive regulation of interleukin-1 beta production,GO,32731,biological_process +106460,106460,neurotrophin TRK receptor signaling pathway,GO,48011,biological_process +106466,106466,hepatocyte growth factor receptor signaling pathway,GO,48012,biological_process +106467,106467,ephrin receptor signaling pathway,GO,48013,biological_process +106468,106468,insulin-like growth factor receptor signaling pathway,GO,48009,biological_process +106547,106547,negative regulation of membrane protein ectodomain proteolysis,GO,51045,biological_process +106573,106573,cellular response to L-ascorbic acid,GO,71298,biological_process +106585,106585,positive regulation of stress fiber assembly,GO,51496,biological_process +106601,106601,negative regulation of endothelial cell apoptotic process,GO,2000352,biological_process +106602,106602,positive regulation of endothelial cell apoptotic process,GO,2000353,biological_process +106622,106622,proteasome core complex assembly,GO,80129,biological_process +106624,106624,cellular response to oxidised low-density lipoprotein particle stimulus,GO,140052,biological_process +106625,106625,cellular response to low-density lipoprotein particle stimulus,GO,71404,biological_process +106653,106653,MHC class II biosynthetic process,GO,45342,biological_process +106670,106670,hyaluronan biosynthetic process,GO,30213,biological_process +106682,106682,cellular response to interleukin-4,GO,71353,biological_process +106708,106708,heterochromatin maintenance,GO,70829,biological_process +106711,106711,cellular defense response,GO,6968,biological_process +106724,106724,positive regulation of focal adhesion assembly,GO,51894,biological_process +106727,106727,autophagosome assembly,GO,45,biological_process +106762,106762,vascular endothelial growth factor production,GO,10573,biological_process +106818,106818,positive regulation of B cell proliferation,GO,30890,biological_process +106841,106841,substrate adhesion-dependent cell spreading,GO,34446,biological_process +106858,106858,positive regulation of gastric mucosal blood circulation,GO,1904346,biological_process +106871,106871,hyaluronan catabolic process,GO,30214,biological_process +106930,106930,positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway,GO,1902237,biological_process +106936,106936,negative regulation of macrophage apoptotic process,GO,2000110,biological_process +106938,106938,negative regulation of neutrophil apoptotic process,GO,33030,biological_process +106945,106945,detection of lipopolysaccharide,GO,32497,biological_process +106981,106981,mRNA transcription by RNA polymerase II,GO,42789,biological_process +107020,107020,"positive regulation of substrate-dependent cell migration, cell attachment to substrate",GO,1904237,biological_process +107077,107077,positive regulation of cortisol secretion,GO,51464,biological_process +107095,107095,positive regulation of toll-like receptor 4 signaling pathway,GO,34145,biological_process +107121,107121,negative regulation of myosin-light-chain-phosphatase activity,GO,35509,biological_process +107142,107142,embryo implantation,GO,7566,biological_process +107146,107146,positive regulation of flagellated sperm motility involved in capacitation,GO,60474,biological_process +107207,107207,nitric oxide production involved in inflammatory response,GO,2537,biological_process +107216,107216,positive regulation of microglia differentiation,GO,14008,biological_process +107227,107227,sphingomyelin biosynthetic process,GO,6686,biological_process +107252,107252,endoderm development,GO,7492,biological_process +107277,107277,positive regulation of hepatic stellate cell activation,GO,2000491,biological_process +107454,107454,positive regulation of collagen biosynthetic process,GO,32967,biological_process +107470,107470,ossification involved in bone remodeling,GO,43932,biological_process +107494,107494,protein kinase B signaling,GO,43491,biological_process +107499,107499,NIK/NF-kappaB signaling,GO,38061,biological_process +107500,107500,I-kappaB kinase/NF-kappaB signaling,GO,7249,biological_process +107503,107503,hippo signaling,GO,35329,biological_process +107519,107519,positive regulation of miRNA mediated inhibition of translation,GO,1905618,biological_process +107538,107538,negative regulation of pri-miRNA transcription by RNA polymerase II,GO,1902894,biological_process +107563,107563,negative regulation of chemokine (C-C motif) ligand 5 production,GO,71650,biological_process +107572,107572,positive regulation of cell growth involved in cardiac muscle cell development,GO,61051,biological_process +107573,107573,negative regulation of cell growth involved in cardiac muscle cell development,GO,61052,biological_process +107585,107585,enamel mineralization,GO,70166,biological_process +107629,107629,positive regulation of intestinal epithelial structure maintenance,GO,60731,biological_process +107630,107630,liver regeneration,GO,97421,biological_process +107644,107644,positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway,GO,70434,biological_process +107652,107652,T follicular helper cell differentiation,GO,61470,biological_process +107672,107672,positive regulation of T cell receptor signaling pathway,GO,50862,biological_process +107674,107674,"complement activation, classical pathway",GO,6958,biological_process +107688,107688,retrotrapezoid nucleus neuron differentiation,GO,61452,biological_process +107691,107691,sympathetic ganglion development,GO,61549,biological_process +107721,107721,sphingosine biosynthetic process,GO,46512,biological_process +107726,107726,positive regulation of release of cytochrome c from mitochondria,GO,90200,biological_process +107748,107748,negative regulation of myeloid dendritic cell activation,GO,30886,biological_process +107799,107799,negative regulation of tau-protein kinase activity,GO,1902948,biological_process +107811,107811,positive regulation of cAMP-dependent protein kinase activity,GO,2000481,biological_process +107899,107899,lymph node development,GO,48535,biological_process +107901,107901,spleen development,GO,48536,biological_process +107945,107945,negative regulation of metanephric mesenchymal cell migration,GO,2000590,biological_process +107986,107986,positive regulation of pri-miRNA transcription by RNA polymerase II,GO,1902895,biological_process +108080,108080,"positive regulation of fructose 1,6-bisphosphate metabolic process",GO,60552,biological_process +108106,108106,positive regulation of PERK-mediated unfolded protein response,GO,1903899,biological_process +108134,108134,positive regulation of follicle-stimulating hormone secretion,GO,46881,biological_process +108150,108150,positive regulation of T-helper 1 cell cytokine production,GO,2000556,biological_process +108171,108171,platelet activation,GO,30168,biological_process +108180,108180,negative regulation of chronic inflammatory response to antigenic stimulus,GO,2875,biological_process +108186,108186,regulation of hair cycle by canonical Wnt signaling pathway,GO,60901,biological_process +108217,108217,negative regulation of platelet-derived growth factor receptor-alpha signaling pathway,GO,2000584,biological_process +108222,108222,T cell receptor V(D)J recombination,GO,33153,biological_process +108244,108244,monocyte aggregation,GO,70487,biological_process +108267,108267,positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway,GO,70430,biological_process +108281,108281,positive regulation of MHC class II biosynthetic process,GO,45348,biological_process +108283,108283,positive regulation of nitric-oxide synthase biosynthetic process,GO,51770,biological_process +108291,108291,activation of protein kinase A activity,GO,34199,biological_process +108292,108292,activation of protein kinase B activity,GO,32148,biological_process +108293,108293,activation of protein kinase C activity,GO,1990051,biological_process +108294,108294,activation of Janus kinase activity,GO,42976,biological_process +108295,108295,activation of NF-kappaB-inducing kinase activity,GO,7250,biological_process +108310,108310,negative regulation of vascular wound healing,GO,61044,biological_process +108348,108348,negative regulation of ERK1 and ERK2 cascade,GO,70373,biological_process +108366,108366,defense response to protozoan,GO,42832,biological_process +108388,108388,cellular response to hypoxia,GO,71456,biological_process +108433,108433,negative regulation of interferon-gamma-mediated signaling pathway,GO,60336,biological_process +108434,108434,positive regulation of interferon-gamma-mediated signaling pathway,GO,60335,biological_process +108458,108458,intestinal epithelial cell development,GO,60576,biological_process +108511,108511,defense response to Gram-negative bacterium,GO,50829,biological_process +108512,108512,defense response to Gram-positive bacterium,GO,50830,biological_process +108535,108535,antigen processing and presentation of exogenous peptide antigen via MHC class II,GO,19886,biological_process +108539,108539,coronary vasculature development,GO,60976,biological_process +108658,108658,negative regulation of appetite by leptin-mediated signaling pathway,GO,38108,biological_process +108732,108732,xenobiotic transport across blood-brain barrier,GO,1990962,biological_process +108736,108736,activation of adenylate cyclase activity,GO,7190,biological_process +108767,108767,negative regulation of vascular associated smooth muscle cell proliferation,GO,1904706,biological_process +108803,108803,positive regulation of histone phosphorylation,GO,33129,biological_process +108804,108804,positive regulation of peptidyl-threonine phosphorylation,GO,10800,biological_process +108806,108806,positive regulation of I-kappaB phosphorylation,GO,1903721,biological_process +108817,108817,negative regulation of collagen biosynthetic process,GO,32966,biological_process +108823,108823,positive regulation of leukocyte adhesion to arterial endothelial cell,GO,1904999,biological_process +108867,108867,actin cytoskeleton reorganization,GO,31532,biological_process +108897,108897,positive regulation of NF-kappaB transcription factor activity,GO,51092,biological_process +108928,108928,protein localization to phagophore assembly site,GO,34497,biological_process +108951,108951,interleukin-7-mediated signaling pathway,GO,38111,biological_process +108952,108952,interleukin-21-mediated signaling pathway,GO,38114,biological_process +108953,108953,interleukin-18-mediated signaling pathway,GO,35655,biological_process +108954,108954,interleukin-12-mediated signaling pathway,GO,35722,biological_process +108959,108959,interleukin-23-mediated signaling pathway,GO,38155,biological_process +108960,108960,interleukin-6-mediated signaling pathway,GO,70102,biological_process +108962,108962,interleukin-9-mediated signaling pathway,GO,38113,biological_process +108964,108964,interleukin-1-mediated signaling pathway,GO,70498,biological_process +108967,108967,interleukin-27-mediated signaling pathway,GO,70106,biological_process +108970,108970,type I interferon signaling pathway,GO,60337,biological_process +108973,108973,interleukin-8-mediated signaling pathway,GO,38112,biological_process +108979,108979,interleukin-2-mediated signaling pathway,GO,38110,biological_process +108980,108980,interferon-gamma-mediated signaling pathway,GO,60333,biological_process +108982,108982,interleukin-15-mediated signaling pathway,GO,35723,biological_process +108984,108984,interleukin-35-mediated signaling pathway,GO,70757,biological_process +109038,109038,T cell homeostasis,GO,43029,biological_process +109055,109055,positive regulation of memory T cell differentiation,GO,43382,biological_process +109062,109062,neutrophil chemotaxis,GO,30593,biological_process +109079,109079,positive regulation of vascular associated smooth muscle cell proliferation,GO,1904707,biological_process +109242,109242,negative regulation of sequestering of triglyceride,GO,10891,biological_process +109243,109243,negative regulation of cholesterol storage,GO,10887,biological_process +109263,109263,cellular response to amyloid-beta,GO,1904646,biological_process +109264,109264,cellular response to muramyl dipeptide,GO,71225,biological_process +109283,109283,epithelial cell proliferation involved in salivary gland morphogenesis,GO,60664,biological_process +109299,109299,positive regulation of tumor necrosis factor (ligand) superfamily member 11 production,GO,2000309,biological_process +109300,109300,negative regulation of tumor necrosis factor (ligand) superfamily member 11 production,GO,2000308,biological_process +109305,109305,protein destabilization,GO,31648,biological_process +109306,109306,protein stabilization,GO,50821,biological_process +109332,109332,nucleotide-binding oligomerization domain containing 2 signaling pathway,GO,70431,biological_process +109333,109333,nucleotide-binding oligomerization domain containing 1 signaling pathway,GO,70427,biological_process +109343,109343,negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation,GO,1903125,biological_process +109344,109344,positive regulation of T-helper 1 cell differentiation,GO,45627,biological_process +109345,109345,positive regulation of T-helper 2 cell differentiation,GO,45630,biological_process +109349,109349,positive regulation of plasma cell differentiation,GO,1900100,biological_process +109350,109350,positive regulation of neutrophil degranulation,GO,43315,biological_process +109351,109351,"positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response",GO,32834,biological_process +109359,109359,removal of superoxide radicals,GO,19430,biological_process +109393,109393,calcium-independent cell-matrix adhesion,GO,7161,biological_process +109397,109397,smooth muscle cell-matrix adhesion,GO,61302,biological_process +109398,109398,negative regulation of gap junction assembly,GO,1903597,biological_process +109399,109399,negative regulation of bicellular tight junction assembly,GO,1903347,biological_process +109427,109427,tetrahydrofolate interconversion,GO,35999,biological_process +109430,109430,positive regulation of hippocampal neuron apoptotic process,GO,110090,biological_process +109433,109433,histone H3-R17 methylation,GO,34971,biological_process +109498,109498,negative regulation of tyrosine phosphorylation of STAT protein,GO,42532,biological_process +109506,109506,embryonic cranial skeleton morphogenesis,GO,48701,biological_process +109515,109515,positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target,GO,2860,biological_process +109532,109532,noradrenergic neuron development,GO,3358,biological_process +109537,109537,positive regulation of growth rate,GO,40010,biological_process +109544,109544,cellular response to tumor necrosis factor,GO,71356,biological_process +109545,109545,cellular response to interferon-gamma,GO,71346,biological_process +109546,109546,cellular response to interleukin-1,GO,71347,biological_process +109554,109554,cellular response to interleukin-6,GO,71354,biological_process +109555,109555,cellular response to leukemia inhibitory factor,GO,1990830,biological_process +109565,109565,cellular response to interleukin-7,GO,98761,biological_process +109596,109596,activation-induced cell death of T cells,GO,6924,biological_process +109601,109601,necroptotic process,GO,70266,biological_process +109647,109647,paraxial mesoderm morphogenesis,GO,48340,biological_process +109652,109652,induction of positive chemotaxis,GO,50930,biological_process +109653,109653,positive regulation of Rho protein signal transduction,GO,35025,biological_process +109687,109687,positive regulation of protein autoubiquitination,GO,1902499,biological_process +109705,109705,toll-like receptor 9 signaling pathway,GO,34162,biological_process +109754,109754,negative regulation of timing of catagen,GO,51796,biological_process +109773,109773,positive regulation of vascular associated smooth muscle cell apoptotic process,GO,1905461,biological_process +109784,109784,lipid phosphorylation,GO,46834,biological_process +109792,109792,T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell,GO,2291,biological_process +109810,109810,Fc-gamma receptor signaling pathway involved in phagocytosis,GO,38096,biological_process +109821,109821,plasma cell differentiation,GO,2317,biological_process +109823,109823,germinal center B cell differentiation,GO,2314,biological_process +109857,109857,anterior neural tube closure,GO,61713,biological_process +109859,109859,neural tube closure,GO,1843,biological_process +109885,109885,positive regulation of keratinocyte proliferation,GO,10838,biological_process +109887,109887,positive regulation of cholangiocyte proliferation,GO,1904056,biological_process +109922,109922,positive regulation of JNK cascade,GO,46330,biological_process +109944,109944,B cell proliferation involved in immune response,GO,2322,biological_process +109977,109977,positive regulation of chemokine (C-X-C motif) ligand 2 production,GO,2000343,biological_process +110010,110010,complement-mediated synapse pruning,GO,150062,biological_process +110055,110055,behavioral response to nicotine,GO,35095,biological_process +110057,110057,adult feeding behavior,GO,8343,biological_process +110061,110061,extrinsic apoptotic signaling pathway in absence of ligand,GO,97192,biological_process +110070,110070,positive regulation of monocyte chemotactic protein-1 production,GO,71639,biological_process +110071,110071,positive regulation of fractalkine production,GO,32724,biological_process +110078,110078,hepatocyte apoptotic process,GO,97284,biological_process +110081,110081,endothelial cell apoptotic process,GO,72577,biological_process +110133,110133,positive regulation of superoxide anion generation,GO,32930,biological_process +110136,110136,positive regulation of microglial cell mediated cytotoxicity,GO,1904151,biological_process +110157,110157,postsynapse to nucleus signaling pathway,GO,99527,biological_process +110187,110187,negative regulation of interleukin-1 alpha production,GO,32690,biological_process +110275,110275,brown fat cell differentiation,GO,50873,biological_process +110313,110313,positive regulation of heterotypic cell-cell adhesion,GO,34116,biological_process +110357,110357,stimulatory C-type lectin receptor signaling pathway,GO,2223,biological_process +110372,110372,macrophage chemotaxis,GO,48246,biological_process +110374,110374,monocyte chemotaxis,GO,2548,biological_process +110381,110381,negative stranded viral RNA replication,GO,39689,biological_process +110397,110397,JNK cascade,GO,7254,biological_process +110411,110411,lipoprotein transport,GO,42953,biological_process +110425,110425,positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway,GO,51482,biological_process +110462,110462,negative regulation of extracellular matrix disassembly,GO,10716,biological_process +110492,110492,negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway,GO,2001268,biological_process +110502,110502,positive regulation of microglial cell activation,GO,1903980,biological_process +110548,110548,connective tissue replacement involved in inflammatory response wound healing,GO,2248,biological_process +110576,110576,cellular response to UV-A,GO,71492,biological_process +110581,110581,hypochlorous acid biosynthetic process,GO,2149,biological_process +110607,110607,positive regulation of erythrocyte differentiation,GO,45648,biological_process +110627,110627,positive regulation of prostaglandin-E synthase activity,GO,2000363,biological_process +110639,110639,maintenance of blood-brain barrier,GO,35633,biological_process +110652,110652,positive regulation of myosin light chain kinase activity,GO,35505,biological_process +110657,110657,positive regulation of isotype switching to IgA isotypes,GO,48298,biological_process +110675,110675,detection of oxidative stress,GO,70994,biological_process +110695,110695,myeloid dendritic cell antigen processing and presentation,GO,2469,biological_process +110697,110697,positive regulation of immature T cell proliferation in thymus,GO,33092,biological_process +110781,110781,locomotory exploration behavior,GO,35641,biological_process +110793,110793,positive regulation of prostaglandin-endoperoxide synthase activity,GO,60585,biological_process +110795,110795,positive regulation of superoxide dismutase activity,GO,1901671,biological_process +110812,110812,leukocyte tethering or rolling,GO,50901,biological_process +110898,110898,negative regulation of natural killer cell chemotaxis,GO,2000502,biological_process +110935,110935,negative regulation of glucose import,GO,46325,biological_process +110950,110950,host-mediated regulation of intestinal microbiota composition,GO,48874,biological_process +110958,110958,aortic valve morphogenesis,GO,3180,biological_process +110960,110960,positive regulation of cardiac muscle cell apoptotic process,GO,10666,biological_process +110961,110961,negative regulation of cardiac muscle cell apoptotic process,GO,10667,biological_process +111076,111076,type B pancreatic cell development,GO,3323,biological_process +111083,111083,negative regulation of hepatocyte apoptotic process,GO,1903944,biological_process +111116,111116,phospholipid homeostasis,GO,55091,biological_process +111148,111148,transcription initiation from RNA polymerase II promoter,GO,6367,biological_process +111174,111174,sensory perception of sound,GO,7605,biological_process +111177,111177,activation of JUN kinase activity,GO,7257,biological_process +111210,111210,positive regulation of type B pancreatic cell apoptotic process,GO,2000676,biological_process +111223,111223,negative regulation of interleukin-6-mediated signaling pathway,GO,70104,biological_process +111232,111232,"negative regulation of circadian sleep/wake cycle, REM sleep",GO,42322,biological_process +111256,111256,sequestering of triglyceride,GO,30730,biological_process +111309,111309,superoxide anion generation,GO,42554,biological_process +111360,111360,negative regulation of single-species biofilm formation in or on host organism,GO,1900229,biological_process +111364,111364,negative regulation of late endosome to lysosome transport,GO,1902823,biological_process +111366,111366,cytoplasmic sequestering of NF-kappaB,GO,7253,biological_process +111372,111372,positive regulation of synaptic vesicle endocytosis,GO,1900244,biological_process +111399,111399,antigen processing and presentation of endogenous peptide antigen via MHC class II,GO,2491,biological_process +111404,111404,homophilic cell adhesion via plasma membrane adhesion molecules,GO,7156,biological_process +111410,111410,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,GO,7157,biological_process +111413,111413,positive regulation of bone mineralization involved in bone maturation,GO,1900159,biological_process +111445,111445,"positive regulation of circadian sleep/wake cycle, non-REM sleep",GO,46010,biological_process +111455,111455,negative regulation of vascular associated smooth muscle cell migration,GO,1904753,biological_process +111491,111491,positive regulation of interferon-beta production,GO,32728,biological_process +111551,111551,positive regulation of Schwann cell differentiation,GO,14040,biological_process +111558,111558,positive regulation of 1-phosphatidylinositol-3-kinase activity,GO,61903,biological_process +111574,111574,positive regulation of substrate adhesion-dependent cell spreading,GO,1900026,biological_process +111577,111577,positive regulation of NK T cell proliferation,GO,51142,biological_process +111631,111631,cerebellar granule cell precursor proliferation,GO,21930,biological_process +111637,111637,positive regulation of lamellipodium assembly,GO,10592,biological_process +111657,111657,positive regulation of appetite,GO,32100,biological_process +111706,111706,positive regulation of neutrophil chemotaxis,GO,90023,biological_process +111726,111726,negative regulation of interleukin-1-mediated signaling pathway,GO,2000660,biological_process +111727,111727,negative regulation of interleukin-4-mediated signaling pathway,GO,1902215,biological_process +111728,111728,negative regulation of interleukin-2-mediated signaling pathway,GO,1902206,biological_process +111729,111729,negative regulation of tumor necrosis factor-mediated signaling pathway,GO,10804,biological_process +111733,111733,negative regulation of macrophage colony-stimulating factor signaling pathway,GO,1902227,biological_process +111753,111753,negative regulation of activated T cell proliferation,GO,46007,biological_process +111827,111827,embryonic liver development,GO,1990402,biological_process +111880,111880,T-helper 2 cell cytokine production,GO,35745,biological_process +112001,112001,negative regulation of glucagon secretion,GO,70093,biological_process +112023,112023,negative regulation of macrophage cytokine production,GO,10936,biological_process +112026,112026,ceramide translocation,GO,99040,biological_process +112030,112030,positive regulation of insulin secretion involved in cellular response to glucose stimulus,GO,35774,biological_process +112055,112055,cellular response to hydrogen peroxide,GO,70301,biological_process +112086,112086,positive regulation of small intestine smooth muscle contraction,GO,1904349,biological_process +112105,112105,positive regulation of receptor signaling pathway via JAK-STAT,GO,46427,biological_process +112127,112127,positive regulation of interferon-alpha production,GO,32727,biological_process +112158,112158,positive regulation of T-helper 17 cell lineage commitment,GO,2000330,biological_process +112177,112177,positive regulation of activated T cell proliferation,GO,42104,biological_process +112193,112193,positive regulation of sprouting angiogenesis,GO,1903672,biological_process +112273,112273,peptide antigen assembly with MHC class II protein complex,GO,2503,biological_process +112333,112333,positive regulation of vascular endothelial cell proliferation,GO,1905564,biological_process +112344,112344,positive regulation of phosphatidic acid biosynthetic process,GO,1905695,biological_process +112365,112365,xenophagy,GO,98792,biological_process +112373,112373,positive regulation of histone deacetylase activity,GO,1901727,biological_process +112472,112472,cellular response to dopamine,GO,1903351,biological_process +112474,112474,cellular response to epinephrine stimulus,GO,71872,biological_process +112487,112487,neutrophil degranulation,GO,43312,biological_process +112568,112568,PERK-mediated unfolded protein response,GO,36499,biological_process +112582,112582,T-helper 17 cell lineage commitment,GO,72540,biological_process +112695,112695,positive regulation of extracellular matrix disassembly,GO,90091,biological_process +112724,112724,positive regulation of core promoter binding,GO,1904798,biological_process +112766,112766,positive regulation of luteinizing hormone secretion,GO,33686,biological_process +112789,112789,positive regulation of monocyte differentiation,GO,45657,biological_process +112803,112803,ureteric bud development,GO,1657,biological_process +112849,112849,L-fucose catabolic process,GO,42355,biological_process +112918,112918,low-density lipoprotein particle remodeling,GO,34374,biological_process +112926,112926,negative regulation of interferon-alpha production,GO,32687,biological_process +113033,113033,detection of muramyl dipeptide,GO,32498,biological_process +113042,113042,"blood coagulation, fibrin clot formation",GO,72378,biological_process +113108,113108,negative regulation of cardiac muscle hypertrophy in response to stress,GO,1903243,biological_process +113109,113109,in utero embryonic development,GO,1701,biological_process +113168,113168,establishment of endothelial intestinal barrier,GO,90557,biological_process +113169,113169,negative regulation of alkaline phosphatase activity,GO,10693,biological_process +113213,113213,hepatic immune response,GO,2384,biological_process +113243,113243,energy homeostasis,GO,97009,biological_process +113244,113244,multicellular organismal iron ion homeostasis,GO,60586,biological_process +113272,113272,endochondral bone growth,GO,3416,biological_process +113290,113290,positive regulation of tumor necrosis factor production,GO,32760,biological_process +113324,113324,negative regulation of protein processing involved in protein targeting to mitochondrion,GO,1903217,biological_process +113338,113338,positive regulation of apoptotic DNA fragmentation,GO,1902512,biological_process +113399,113399,(R)-carnitine transmembrane transport,GO,1902270,biological_process +113406,113406,negative regulation of lung blood pressure,GO,61767,biological_process +113408,113408,intestinal epithelial structure maintenance,GO,60729,biological_process +113411,113411,isotype switching to IgA isotypes,GO,48290,biological_process +113456,113456,T cell receptor signaling pathway,GO,50852,biological_process +113480,113480,antifungal humoral response,GO,19732,biological_process +113527,113527,mineralocorticoid receptor signaling pathway,GO,31959,biological_process +113577,113577,hepatocyte proliferation,GO,72574,biological_process +113597,113597,positive regulation of glucose import,GO,46326,biological_process +113641,113641,entry of bacterium into host cell,GO,35635,biological_process +113738,113738,nitrogen catabolite activation of transcription from RNA polymerase II promoter,GO,1080,biological_process +113770,113770,establishment of Sertoli cell barrier,GO,97368,biological_process +113784,113784,negative regulation of tumor necrosis factor production,GO,32720,biological_process +113811,113811,negative regulation of interleukin-1 beta production,GO,32691,biological_process +113885,113885,protein lipidation involved in autophagosome assembly,GO,61739,biological_process +113912,113912,DN3 thymocyte differentiation,GO,1904156,biological_process +113913,113913,DN2 thymocyte differentiation,GO,1904155,biological_process +113947,113947,positive regulation of keratinocyte migration,GO,51549,biological_process +113958,113958,blood coagulation,GO,7596,biological_process +113985,113985,intracellular distribution of mitochondria,GO,48312,biological_process +113995,113995,positive regulation of p38MAPK cascade,GO,1900745,biological_process +114001,114001,macrophage derived foam cell differentiation,GO,10742,biological_process +114024,114024,positive regulation of peptidyl-serine phosphorylation of STAT protein,GO,33141,biological_process +114073,114073,antimicrobial humoral immune response mediated by antimicrobial peptide,GO,61844,biological_process +114118,114118,G2/M transition of mitotic cell cycle,GO,86,biological_process +114120,114120,activation of cysteine-type endopeptidase activity,GO,97202,biological_process +114257,114257,Arp2/3 complex-mediated actin nucleation,GO,34314,biological_process +114301,114301,membrane to membrane docking,GO,22614,biological_process +114305,114305,positive regulation of T-helper 2 cell cytokine production,GO,2000553,biological_process +114326,114326,"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent",GO,2479,biological_process +114344,114344,positive regulation of cholesterol efflux,GO,10875,biological_process +114380,114380,positive regulation of growth factor dependent skeletal muscle satellite cell proliferation,GO,1902728,biological_process +114413,114413,tyrosine phosphorylation of STAT protein,GO,7260,biological_process +114429,114429,activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway,GO,97296,biological_process +114453,114453,tumor necrosis factor production,GO,32640,biological_process +114455,114455,receptor signaling pathway via JAK-STAT,GO,7259,biological_process +114456,114456,positive regulation of macrophage cytokine production,GO,60907,biological_process +114503,114503,negative regulation of positive thymic T cell selection,GO,1902233,biological_process +114551,114551,protein localization to endoplasmic reticulum exit site,GO,70973,biological_process +114555,114555,positive regulation of defense response to virus by host,GO,2230,biological_process +114574,114574,activation of GTPase activity,GO,90630,biological_process +114613,114613,positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria,GO,6965,biological_process +114681,114681,positive regulation of calcineurin-NFAT signaling cascade,GO,70886,biological_process +114699,114699,low-density lipoprotein particle clearance,GO,34383,biological_process +114797,114797,histone H3-Y41 phosphorylation,GO,35409,biological_process +114807,114807,negative regulation of vascular associated smooth muscle cell apoptotic process,GO,1905460,biological_process +114831,114831,fever generation,GO,1660,biological_process +114900,114900,gastric emptying,GO,35483,biological_process +114919,114919,heart looping,GO,1947,biological_process +114926,114926,negative regulation of bone resorption,GO,45779,biological_process +114939,114939,phosphatidylinositol 3-kinase signaling,GO,14065,biological_process +114940,114940,response to gold nanoparticle,GO,1990268,biological_process +114997,114997,growth hormone receptor signaling pathway via JAK-STAT,GO,60397,biological_process +115023,115023,bone mineralization involved in bone maturation,GO,35630,biological_process +115034,115034,apoptotic DNA fragmentation,GO,6309,biological_process +115045,115045,Peyer's patch development,GO,48541,biological_process +115174,115174,primary miRNA binding,GO,70878,molecular_function +115192,115192,protein threonine kinase activity,GO,106311,molecular_function +115199,115199,GTP-dependent protein kinase activity,GO,34211,molecular_function +115202,115202,protein serine kinase activity,GO,106310,molecular_function +115459,115459,heme binding,GO,20037,molecular_function +116467,116467,magnesium ion binding,GO,287,molecular_function +116663,116663,secondary active organic cation transmembrane transporter activity,GO,8513,molecular_function +116712,116712,LIM domain binding,GO,30274,molecular_function +116715,116715,ankyrin repeat binding,GO,71532,molecular_function +116725,116725,CARD domain binding,GO,50700,molecular_function +116734,116734,DNA binding domain binding,GO,50692,molecular_function +116750,116750,SH2 domain binding,GO,42169,molecular_function +116751,116751,PDZ domain binding,GO,30165,molecular_function +116753,116753,disordered domain specific binding,GO,97718,molecular_function +116781,116781,LBD domain binding,GO,50693,molecular_function +116782,116782,heparin binding,GO,8201,molecular_function +116786,116786,peptidoglycan binding,GO,42834,molecular_function +116806,116806,G protein-coupled bile acid receptor activity,GO,38182,molecular_function +116854,116854,interleukin-2 binding,GO,19976,molecular_function +116858,116858,interleukin-10 binding,GO,19969,molecular_function +117085,117085,phosphate ion binding,GO,42301,molecular_function +117390,117390,chenodeoxycholic acid binding,GO,1902122,molecular_function +117411,117411,interleukin-2 receptor binding,GO,5134,molecular_function +117413,117413,interleukin-6 receptor binding,GO,5138,molecular_function +117417,117417,interleukin-12 receptor binding,GO,5143,molecular_function +117418,117418,interleukin-10 receptor binding,GO,5141,molecular_function +117638,117638,growth factor activity,GO,8083,molecular_function +117654,117654,ghrelin receptor binding,GO,31768,molecular_function +117962,117962,NAD+ kinase activity,GO,3951,molecular_function +117973,117973,sphinganine kinase activity,GO,8481,molecular_function +118059,118059,complement component C1q complex binding,GO,1849,molecular_function +118069,118069,T cell receptor binding,GO,42608,molecular_function +118079,118079,insulin receptor binding,GO,5158,molecular_function +118087,118087,proteasome binding,GO,70628,molecular_function +118101,118101,G-protein beta/gamma-subunit complex binding,GO,31683,molecular_function +118105,118105,beta-catenin destruction complex binding,GO,1904713,molecular_function +118224,118224,oxalate transmembrane transporter activity,GO,19531,molecular_function +118509,118509,MHC class II receptor activity,GO,32395,molecular_function +118985,118985,insulin-like growth factor receptor binding,GO,5159,molecular_function +118994,118994,leptin receptor binding,GO,1990460,molecular_function +118999,118999,acetylcholine receptor binding,GO,33130,molecular_function +119014,119014,CD4 receptor binding,GO,42609,molecular_function +119015,119015,scavenger receptor binding,GO,5124,molecular_function +119029,119029,sialic acid binding,GO,33691,molecular_function +119045,119045,protein C-terminus binding,GO,8022,molecular_function +119049,119049,calmodulin binding,GO,5516,molecular_function +119050,119050,GTPase activating protein binding,GO,32794,molecular_function +119055,119055,beta-catenin binding,GO,8013,molecular_function +119064,119064,chaperone binding,GO,51087,molecular_function +119074,119074,insulin receptor substrate binding,GO,43560,molecular_function +119080,119080,co-receptor binding,GO,39706,molecular_function +119084,119084,gamma-catenin binding,GO,45295,molecular_function +119096,119096,MDM2/MDM4 family protein binding,GO,97371,molecular_function +119106,119106,ion channel binding,GO,44325,molecular_function +119328,119328,growth hormone receptor binding,GO,5131,molecular_function +119330,119330,interferon-gamma receptor binding,GO,5133,molecular_function +119346,119346,interleukin-23 receptor binding,GO,45519,molecular_function +119362,119362,N-formyl peptide receptor activity,GO,4982,molecular_function +119433,119433,chemokine activity,GO,8009,molecular_function +119560,119560,D-erythro-sphingosine kinase activity,GO,17050,molecular_function +119596,119596,interleukin-12 alpha subunit binding,GO,42164,molecular_function +119635,119635,scavenger receptor activity,GO,5044,molecular_function +119696,119696,choline binding,GO,33265,molecular_function +119707,119707,CCR6 chemokine receptor binding,GO,31731,molecular_function +119712,119712,CCR2 chemokine receptor binding,GO,31727,molecular_function +119713,119713,CCR5 chemokine receptor binding,GO,31730,molecular_function +119776,119776,low-density lipoprotein particle receptor binding,GO,50750,molecular_function +119847,119847,peroxidase inhibitor activity,GO,36479,molecular_function +119968,119968,galactoside 2-alpha-L-fucosyltransferase activity,GO,8107,molecular_function +119999,119999,superoxide-generating NADPH oxidase activator activity,GO,16176,molecular_function +120259,120259,arachidonic acid binding,GO,50544,molecular_function +120291,120291,ankyrin binding,GO,30506,molecular_function +120568,120568,interleukin-23 binding,GO,42019,molecular_function +120581,120581,histone deacetylase binding,GO,42826,molecular_function +120584,120584,DEAD/H-box RNA helicase binding,GO,17151,molecular_function +120629,120629,D5 dopamine receptor binding,GO,31752,molecular_function +120794,120794,ATP binding,GO,5524,molecular_function +120879,120879,"interleukin-1, type II, blocking receptor activity",GO,4910,molecular_function +121108,121108,lipopolysaccharide binding,GO,1530,molecular_function +121112,121112,nuclear receptor activity,GO,4879,molecular_function +121113,121113,"DNA-binding transcription activator activity, RNA polymerase II-specific",GO,1228,molecular_function +121114,121114,"DNA-binding transcription repressor activity, RNA polymerase II-specific",GO,1227,molecular_function +121267,121267,growth hormone-releasing hormone activity,GO,16608,molecular_function +121367,121367,interleukin-8 receptor activity,GO,4918,molecular_function +121591,121591,protein-cysteine methyltransferase activity,GO,106363,molecular_function +121636,121636,virus receptor activity,GO,1618,molecular_function +121655,121655,complement component C4b binding,GO,1855,molecular_function +121658,121658,complement component C3b binding,GO,1851,molecular_function +121719,121719,serine-type endopeptidase activity,GO,4252,molecular_function +121815,121815,BH3 domain binding,GO,51434,molecular_function +121941,121941,chloride transmembrane transporter activity,GO,15108,molecular_function +122016,122016,interleukin-2 receptor activity,GO,4911,molecular_function +122022,122022,interleukin-18 receptor activity,GO,42008,molecular_function +122023,122023,interleukin-10 receptor activity,GO,4920,molecular_function +122044,122044,interleukin-23 receptor activity,GO,42020,molecular_function +122046,122046,interleukin-7 receptor activity,GO,4917,molecular_function +122081,122081,mineralocorticoid receptor binding,GO,31962,molecular_function +122117,122117,muramyl dipeptide binding,GO,32500,molecular_function +122191,122191,IgG binding,GO,19864,molecular_function +122208,122208,caspase binding,GO,89720,molecular_function +122386,122386,Hsp70 protein binding,GO,30544,molecular_function +122387,122387,Hsp90 protein binding,GO,51879,molecular_function +122445,122445,peptide antigen binding,GO,42605,molecular_function +122448,122448,amyloid-beta binding,GO,1540,molecular_function +122450,122450,E-box binding,GO,70888,molecular_function +122514,122514,low-density lipoprotein particle binding,GO,30169,molecular_function +122515,122515,metalloaminopeptidase activity,GO,70006,molecular_function +122601,122601,protein phosphatase 2A binding,GO,51721,molecular_function +122627,122627,NAD(P)+ nucleosidase activity,GO,50135,molecular_function +122720,122720,non-membrane spanning protein tyrosine phosphatase activity,GO,4726,molecular_function +122739,122739,methylenetetrahydrofolate reductase NADH activity,GO,106312,molecular_function +122740,122740,methylenetetrahydrofolate reductase NADPH activity,GO,106313,molecular_function +122806,122806,promoter-specific chromatin binding,GO,1990841,molecular_function +122819,122819,primary amine oxidase activity,GO,8131,molecular_function +122836,122836,FAD binding,GO,71949,molecular_function +122869,122869,lipopolysaccharide immune receptor activity,GO,1875,molecular_function +122946,122946,NF-kappaB binding,GO,51059,molecular_function +122947,122947,STAT family protein binding,GO,97677,molecular_function +122948,122948,NFAT protein binding,GO,51525,molecular_function +123006,123006,phosphatidylcholine floppase activity,GO,90554,molecular_function +123017,123017,GTP binding,GO,5525,molecular_function +123091,123091,cyclin-dependent protein serine/threonine kinase inhibitor activity,GO,4861,molecular_function +123116,123116,RNA polymerase II core promoter sequence-specific DNA binding,GO,979,molecular_function +123189,123189,phosphatidylinositol-3-phosphate binding,GO,32266,molecular_function +123204,123204,phosphatidylethanolamine flippase activity,GO,90555,molecular_function +123249,123249,R-SMAD binding,GO,70412,molecular_function +123250,123250,co-SMAD binding,GO,70410,molecular_function +123251,123251,I-SMAD binding,GO,70411,molecular_function +123289,123289,MHC class II protein complex binding,GO,23026,molecular_function +123317,123317,guanyl-nucleotide exchange factor activity,GO,5085,molecular_function +123359,123359,unmethylated CpG binding,GO,45322,molecular_function +123407,123407,syntaxin-1 binding,GO,17075,molecular_function +123430,123430,type II transforming growth factor beta receptor binding,GO,5114,molecular_function +123431,123431,type I transforming growth factor beta receptor binding,GO,34713,molecular_function +123432,123432,type III transforming growth factor beta receptor binding,GO,34714,molecular_function +123446,123446,ceramide floppase activity,GO,99038,molecular_function +123459,123459,histone kinase activity (H3-Y41 specific),GO,35401,molecular_function +123515,123515,cysteine-type endopeptidase activity involved in apoptotic signaling pathway,GO,97199,molecular_function +123516,123516,cysteine-type endopeptidase activity involved in execution phase of apoptosis,GO,97200,molecular_function +123554,123554,sphingosine-1-phosphate receptor activity,GO,38036,molecular_function +123579,123579,tumor necrosis factor receptor binding,GO,5164,molecular_function +123654,123654,phospholipase A2 activator activity,GO,16005,molecular_function +123748,123748,type 1 angiotensin receptor binding,GO,31702,molecular_function +123914,123914,ubiquitin conjugating enzyme binding,GO,31624,molecular_function +123917,123917,JUN kinase kinase kinase activity,GO,4706,molecular_function +123983,123983,transcription coactivator binding,GO,1223,molecular_function +124035,124035,ubiquitin protein ligase binding,GO,31625,molecular_function +124050,124050,siRNA binding,GO,35197,molecular_function +124125,124125,protein homodimerization activity,GO,42803,molecular_function +124128,124128,protein heterodimerization activity,GO,46982,molecular_function +124137,124137,interleukin-8 binding,GO,19959,molecular_function +124184,124184,"NAD+ nucleotidase, cyclic ADP-ribose generating",GO,61809,molecular_function +124195,124195,retinoid X receptor binding,GO,46965,molecular_function +124208,124208,small GTPase binding,GO,31267,molecular_function +124245,124245,extracellular space,GO,5615,cellular_component +124249,124249,nucleoplasm,GO,5654,cellular_component +124254,124254,phagocytic cup,GO,1891,cellular_component +124260,124260,nuclear matrix,GO,16363,cellular_component +124298,124298,sperm midpiece,GO,97225,cellular_component +124326,124326,lateral plasma membrane,GO,16328,cellular_component +124357,124357,immunological synapse,GO,1772,cellular_component +124358,124358,endoplasmic reticulum exit site,GO,70971,cellular_component +124455,124455,midbody,GO,30496,cellular_component +124474,124474,apical part of cell,GO,45177,cellular_component +124479,124479,cell surface,GO,9986,cellular_component +124481,124481,axoneme,GO,5930,cellular_component +124518,124518,perikaryon,GO,43204,cellular_component +124519,124519,sperm principal piece,GO,97228,cellular_component +124597,124597,"multivesicular body, internal vesicle",GO,97487,cellular_component +124627,124627,interleukin-28 receptor complex,GO,32002,cellular_component +124636,124636,interleukin-23 receptor complex,GO,72536,cellular_component +124639,124639,interleukin-6 receptor complex,GO,5896,cellular_component +124646,124646,interleukin-18 receptor complex,GO,45092,cellular_component +124650,124650,interleukin-2 receptor complex,GO,5893,cellular_component +124674,124674,alphav-beta3 integrin-IGF-1-IGF1R complex,GO,35867,cellular_component +124707,124707,catenin complex,GO,16342,cellular_component +124740,124740,NADPH oxidase complex,GO,43020,cellular_component +124764,124764,heterotrimeric G-protein complex,GO,5834,cellular_component +124769,124769,alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex,GO,71065,cellular_component +124827,124827,flotillin complex,GO,16600,cellular_component +124830,124830,alphav-beta3 integrin-vitronectin complex,GO,71062,cellular_component +124869,124869,heteromeric SMAD protein complex,GO,71144,cellular_component +124919,124919,lipopolysaccharide receptor complex,GO,46696,cellular_component +125004,125004,endoplasmic reticulum-Golgi intermediate compartment,GO,5793,cellular_component +125013,125013,mitochondrion,GO,5739,cellular_component +125040,125040,fibrinogen complex,GO,5577,cellular_component +125118,125118,Wnt signalosome,GO,1990909,cellular_component +125123,125123,interleukin-23 complex,GO,70743,cellular_component +125174,125174,interleukin-12 complex,GO,43514,cellular_component +125198,125198,CBM complex,GO,32449,cellular_component +125205,125205,Arp2/3 protein complex,GO,5885,cellular_component +125617,125617,integral component of lumenal side of endoplasmic reticulum membrane,GO,71556,cellular_component +125634,125634,phagophore assembly site membrane,GO,34045,cellular_component +125654,125654,laminin-1 complex,GO,5606,cellular_component +125661,125661,laminin-8 complex,GO,43257,cellular_component +125666,125666,laminin-2 complex,GO,5607,cellular_component +125667,125667,laminin-10 complex,GO,43259,cellular_component +125707,125707,Schaffer collateral - CA1 synapse,GO,98685,cellular_component +125717,125717,trans-Golgi network,GO,5802,cellular_component +125777,125777,endolysosome,GO,36019,cellular_component +125860,125860,ruffle,GO,1726,cellular_component +125870,125870,autolysosome,GO,44754,cellular_component +125942,125942,caveola neck,GO,99400,cellular_component +125960,125960,clathrin-coated pit,GO,5905,cellular_component +125962,125962,apical plasma membrane,GO,16324,cellular_component +125963,125963,basolateral plasma membrane,GO,16323,cellular_component +125993,125993,podosome,GO,2102,cellular_component +125998,125998,centriole,GO,5814,cellular_component +126001,126001,nucleolus,GO,5730,cellular_component +126038,126038,sperm flagellum,GO,36126,cellular_component +126061,126061,nuclear inner membrane,GO,5637,cellular_component +126074,126074,tertiary granule lumen,GO,1904724,cellular_component +126077,126077,mitochondrial matrix,GO,5759,cellular_component +126078,126078,ficolin-1-rich granule lumen,GO,1904813,cellular_component +126092,126092,mitochondrial inner membrane,GO,5743,cellular_component +126093,126093,mitochondrial outer membrane,GO,5741,cellular_component +126102,126102,XY body,GO,1741,cellular_component +126196,126196,extracellular exosome,GO,70062,cellular_component +126226,126226,ficolin-1-rich granule membrane,GO,101003,cellular_component +126228,126228,tertiary granule membrane,GO,70821,cellular_component +126229,126229,specific granule membrane,GO,35579,cellular_component +126261,126261,muscle cell projection membrane,GO,36195,cellular_component +126264,126264,brush border membrane,GO,31526,cellular_component +126289,126289,endolysosome membrane,GO,36020,cellular_component +126309,126309,integrin alphaM-beta2 complex,GO,34688,cellular_component +126329,126329,apical junction complex,GO,43296,cellular_component +126336,126336,mast cell granule,GO,42629,cellular_component +126344,126344,azurophil granule lumen,GO,35578,cellular_component +126355,126355,specific granule,GO,42581,cellular_component +126359,126359,azurophil granule,GO,42582,cellular_component +126428,126428,cytoplasmic cyclin-dependent protein kinase holoenzyme complex,GO,308,cellular_component +126444,126444,vacuole-isolation membrane contact site,GO,120095,cellular_component +126476,126476,insulin-like growth factor ternary complex,GO,42567,cellular_component +126556,126556,ER to Golgi transport vesicle membrane,GO,12507,cellular_component +126596,126596,NLRP3 inflammasome complex,GO,72559,cellular_component +126708,126708,basement membrane,GO,5604,cellular_component +126815,126815,SPOTS complex,GO,35339,cellular_component +126859,126859,microtubule cytoskeleton,GO,15630,cellular_component +126873,126873,focal adhesion,GO,5925,cellular_component +126913,126913,euchromatin,GO,791,cellular_component +126938,126938,cytoplasmic side of mitochondrial outer membrane,GO,32473,cellular_component +126941,126941,early phagosome,GO,32009,cellular_component +126948,126948,mitotic spindle,GO,72686,cellular_component +127022,127022,NF-kappaB p50/p65 complex,GO,35525,cellular_component +127025,127025,inner mucus layer,GO,70702,cellular_component +127026,127026,outer mucus layer,GO,70703,cellular_component +127126,127126,MHC class II protein complex,GO,42613,cellular_component +127133,127133,sarcolemma,GO,42383,cellular_component +127134,127134,sperm plasma membrane,GO,97524,cellular_component +127185,127185,neuronal cell body,GO,43025,cellular_component +127192,127192,platelet alpha granule lumen,GO,31093,cellular_component +127193,127193,platelet dense granule lumen,GO,31089,cellular_component +127195,127195,specific granule lumen,GO,35580,cellular_component +127227,127227,external side of apical plasma membrane,GO,98591,cellular_component +127250,127250,presynaptic cytosol,GO,99523,cellular_component +127256,127256,synaptic vesicle membrane,GO,30672,cellular_component +127358,127358,site of double-strand break,GO,35861,cellular_component +127370,127370,amphisome,GO,44753,cellular_component +127374,127374,caveola,GO,5901,cellular_component +127383,127383,trans-Golgi network membrane,GO,32588,cellular_component +129373,129373,multi-cellular organism,UBERON,468,anatomy +129374,129374,female gonad,UBERON,992,anatomy