diff --git a/.eslintrc.js b/.eslintrc.js
index cea14615959fe..e91c3b6232432 100644
--- a/.eslintrc.js
+++ b/.eslintrc.js
@@ -101,6 +101,7 @@ module.exports = {
 							'isNil',
 							'isNumber',
 							'isObjectLike',
+							'isString',
 							'isUndefined',
 							'keyBy',
 							'keys',
diff --git a/packages/block-editor/src/components/colors/with-colors.js b/packages/block-editor/src/components/colors/with-colors.js
index feca70795771f..8d887612e4cf1 100644
--- a/packages/block-editor/src/components/colors/with-colors.js
+++ b/packages/block-editor/src/components/colors/with-colors.js
@@ -1,7 +1,7 @@
 /**
  * External dependencies
  */
-import { isString, kebabCase, reduce, upperFirst } from 'lodash';
+import { kebabCase, reduce, upperFirst } from 'lodash';
 
 /**
  * WordPress dependencies
@@ -78,7 +78,7 @@ function createColorHOC( colorTypes, withColorPalette ) {
 		( colorObject, colorType ) => {
 			return {
 				...colorObject,
-				...( isString( colorType )
+				...( typeof colorType === 'string'
 					? { [ colorType ]: kebabCase( colorType ) }
 					: colorType ),
 			};
diff --git a/packages/blocks/src/api/registration.js b/packages/blocks/src/api/registration.js
index d36e816c497ff..0d9d5ce575f39 100644
--- a/packages/blocks/src/api/registration.js
+++ b/packages/blocks/src/api/registration.js
@@ -3,15 +3,7 @@
 /**
  * External dependencies
  */
-import {
-	camelCase,
-	isEmpty,
-	isObject,
-	isString,
-	mapKeys,
-	pick,
-	pickBy,
-} from 'lodash';
+import { camelCase, isEmpty, isObject, mapKeys, pick, pickBy } from 'lodash';
 
 /**
  * WordPress dependencies
@@ -302,7 +294,7 @@ function translateBlockSettingUsingI18nSchema(
 	settingValue,
 	textdomain
 ) {
-	if ( isString( i18nSchema ) && isString( settingValue ) ) {
+	if ( typeof i18nSchema === 'string' && typeof settingValue === 'string' ) {
 		// eslint-disable-next-line @wordpress/i18n-no-variables, @wordpress/i18n-text-domain
 		return _x( settingValue, i18nSchema, textdomain );
 	}
diff --git a/packages/blocks/src/api/utils.js b/packages/blocks/src/api/utils.js
index 9ede11d49c5bf..ec5e2ff3bba8c 100644
--- a/packages/blocks/src/api/utils.js
+++ b/packages/blocks/src/api/utils.js
@@ -1,7 +1,7 @@
 /**
  * External dependencies
  */
-import { every, has, isString, reduce, maxBy } from 'lodash';
+import { every, has, reduce, maxBy } from 'lodash';
 import { colord, extend } from 'colord';
 import namesPlugin from 'colord/plugins/names';
 import a11yPlugin from 'colord/plugins/a11y';
@@ -75,7 +75,7 @@ export function isUnmodifiedDefaultBlock( block ) {
 export function isValidIcon( icon ) {
 	return (
 		!! icon &&
-		( isString( icon ) ||
+		( typeof icon === 'string' ||
 			isValidElement( icon ) ||
 			typeof icon === 'function' ||
 			icon instanceof Component )
@@ -126,7 +126,7 @@ export function normalizeIconObject( icon ) {
  * @return {?Object} Block type.
  */
 export function normalizeBlockType( blockTypeOrName ) {
-	if ( isString( blockTypeOrName ) ) {
+	if ( typeof blockTypeOrName === 'string' ) {
 		return getBlockType( blockTypeOrName );
 	}
 
diff --git a/packages/components/CHANGELOG.md b/packages/components/CHANGELOG.md
index e49491f2c0b2e..5da0beec4aa9e 100644
--- a/packages/components/CHANGELOG.md
+++ b/packages/components/CHANGELOG.md
@@ -18,6 +18,8 @@
 -   `Slot`/`Fill`: Refactor away from Lodash ([#42153](https://github.com/WordPress/gutenberg/pull/42153/)).
 -   `ComboboxControl`: Refactor away from `_.deburr()` ([#42169](https://github.com/WordPress/gutenberg/pull/42169/)).
 -   `FormTokenField`: Refactor away from `_.identity()` ([#42215](https://github.com/WordPress/gutenberg/pull/42215/)).
+-   `MenuItem`: Refactor away from `_.isString()` ([#42268](https://github.com/WordPress/gutenberg/pull/42268/)).
+-   `Shortcut`: Refactor away from `_.isString()` ([#42268](https://github.com/WordPress/gutenberg/pull/42268/)).
 
 ### Bug Fix
 
diff --git a/packages/components/src/menu-item/index.js b/packages/components/src/menu-item/index.js
index 79f129f8caa8e..7440b3b38ef35 100644
--- a/packages/components/src/menu-item/index.js
+++ b/packages/components/src/menu-item/index.js
@@ -3,7 +3,6 @@
  * External dependencies
  */
 import classnames from 'classnames';
-import { isString } from 'lodash';
 
 /**
  * WordPress dependencies
@@ -41,7 +40,7 @@ export function MenuItem( props, ref ) {
 		);
 	}
 
-	if ( icon && ! isString( icon ) ) {
+	if ( icon && typeof icon !== 'string' ) {
 		icon = cloneElement( icon, {
 			className: classnames( 'components-menu-items__item-icon', {
 				'has-icon-right': iconPosition === 'right',
diff --git a/packages/components/src/shortcut/index.js b/packages/components/src/shortcut/index.js
index 7863fa1d574b8..89d2c395cd45e 100644
--- a/packages/components/src/shortcut/index.js
+++ b/packages/components/src/shortcut/index.js
@@ -1,7 +1,7 @@
 /**
  * External dependencies
  */
-import { isString, isObject } from 'lodash';
+import { isObject } from 'lodash';
 
 /** @typedef {string | { display: string, ariaLabel: string }} Shortcut */
 /**
@@ -22,7 +22,7 @@ function Shortcut( { shortcut, className } ) {
 	let displayText;
 	let ariaLabel;
 
-	if ( isString( shortcut ) ) {
+	if ( typeof shortcut === 'string' ) {
 		displayText = shortcut;
 	}
 
diff --git a/packages/customize-widgets/src/components/keyboard-shortcut-help-modal/index.js b/packages/customize-widgets/src/components/keyboard-shortcut-help-modal/index.js
index 77911be261001..5739af79abcf7 100644
--- a/packages/customize-widgets/src/components/keyboard-shortcut-help-modal/index.js
+++ b/packages/customize-widgets/src/components/keyboard-shortcut-help-modal/index.js
@@ -2,7 +2,6 @@
  * External dependencies
  */
 import classnames from 'classnames';
-import { isString } from 'lodash';
 
 /**
  * WordPress dependencies
@@ -37,7 +36,7 @@ const ShortcutList = ( { shortcuts } ) => (
 				className="customize-widgets-keyboard-shortcut-help-modal__shortcut"
 				key={ index }
 			>
-				{ isString( shortcut ) ? (
+				{ typeof shortcut === 'string' ? (
 					<DynamicShortcut name={ shortcut } />
 				) : (
 					<Shortcut { ...shortcut } />
diff --git a/packages/edit-post/src/components/keyboard-shortcut-help-modal/index.js b/packages/edit-post/src/components/keyboard-shortcut-help-modal/index.js
index e5177ef2d03f3..19cf9b4525f19 100644
--- a/packages/edit-post/src/components/keyboard-shortcut-help-modal/index.js
+++ b/packages/edit-post/src/components/keyboard-shortcut-help-modal/index.js
@@ -2,7 +2,6 @@
  * External dependencies
  */
 import classnames from 'classnames';
-import { isString } from 'lodash';
 
 /**
  * WordPress dependencies
@@ -41,7 +40,7 @@ const ShortcutList = ( { shortcuts } ) => (
 				className="edit-post-keyboard-shortcut-help-modal__shortcut"
 				key={ index }
 			>
-				{ isString( shortcut ) ? (
+				{ typeof shortcut === 'string' ? (
 					<DynamicShortcut name={ shortcut } />
 				) : (
 					<Shortcut { ...shortcut } />
diff --git a/packages/edit-site/src/components/global-styles/use-global-styles-output.js b/packages/edit-site/src/components/global-styles/use-global-styles-output.js
index 9a8ad4f54282b..2d14c571db41b 100644
--- a/packages/edit-site/src/components/global-styles/use-global-styles-output.js
+++ b/packages/edit-site/src/components/global-styles/use-global-styles-output.js
@@ -6,7 +6,6 @@ import {
 	forEach,
 	get,
 	isEmpty,
-	isString,
 	kebabCase,
 	pickBy,
 	reduce,
@@ -185,7 +184,7 @@ function getStylesDeclarations( blockStyles = {} ) {
 
 			const styleValue = get( blockStyles, pathToValue );
 
-			if ( !! properties && ! isString( styleValue ) ) {
+			if ( !! properties && typeof styleValue !== 'string' ) {
 				Object.entries( properties ).forEach( ( entry ) => {
 					const [ name, prop ] = entry;
 
diff --git a/packages/edit-site/src/components/global-styles/utils.js b/packages/edit-site/src/components/global-styles/utils.js
index 833255b624b47..1e40bb70bdb97 100644
--- a/packages/edit-site/src/components/global-styles/utils.js
+++ b/packages/edit-site/src/components/global-styles/utils.js
@@ -1,7 +1,7 @@
 /**
  * External dependencies
  */
-import { get, find, isString } from 'lodash';
+import { get, find } from 'lodash';
 
 /* Supporting data. */
 export const ROOT_BLOCK_NAME = 'root';
@@ -213,7 +213,7 @@ function getValueFromCustomVariable( features, blockName, variable, path ) {
 }
 
 export function getValueFromVariable( features, blockName, variable ) {
-	if ( ! variable || ! isString( variable ) ) {
+	if ( ! variable || typeof variable !== 'string' ) {
 		return variable;
 	}
 	const USER_VALUE_PREFIX = 'var:';
diff --git a/packages/edit-site/src/components/keyboard-shortcut-help-modal/index.js b/packages/edit-site/src/components/keyboard-shortcut-help-modal/index.js
index 275282b5ac1d1..fc03e16008e30 100644
--- a/packages/edit-site/src/components/keyboard-shortcut-help-modal/index.js
+++ b/packages/edit-site/src/components/keyboard-shortcut-help-modal/index.js
@@ -2,7 +2,6 @@
  * External dependencies
  */
 import classnames from 'classnames';
-import { isString } from 'lodash';
 
 /**
  * WordPress dependencies
@@ -34,7 +33,7 @@ const ShortcutList = ( { shortcuts } ) => (
 				className="edit-site-keyboard-shortcut-help-modal__shortcut"
 				key={ index }
 			>
-				{ isString( shortcut ) ? (
+				{ typeof shortcut === 'string' ? (
 					<DynamicShortcut name={ shortcut } />
 				) : (
 					<Shortcut { ...shortcut } />
diff --git a/packages/edit-widgets/src/components/keyboard-shortcut-help-modal/index.js b/packages/edit-widgets/src/components/keyboard-shortcut-help-modal/index.js
index 51b2a47e5f127..c33efcbb18167 100644
--- a/packages/edit-widgets/src/components/keyboard-shortcut-help-modal/index.js
+++ b/packages/edit-widgets/src/components/keyboard-shortcut-help-modal/index.js
@@ -2,7 +2,6 @@
  * External dependencies
  */
 import classnames from 'classnames';
-import { isString } from 'lodash';
 
 /**
  * WordPress dependencies
@@ -37,7 +36,7 @@ const ShortcutList = ( { shortcuts } ) => (
 				className="edit-widgets-keyboard-shortcut-help-modal__shortcut"
 				key={ index }
 			>
-				{ isString( shortcut ) ? (
+				{ typeof shortcut === 'string' ? (
 					<DynamicShortcut name={ shortcut } />
 				) : (
 					<Shortcut { ...shortcut } />
diff --git a/packages/editor/src/store/selectors.js b/packages/editor/src/store/selectors.js
index 17c342b932973..506a6a1d4c137 100644
--- a/packages/editor/src/store/selectors.js
+++ b/packages/editor/src/store/selectors.js
@@ -1,7 +1,7 @@
 /**
  * External dependencies
  */
-import { find, get, has, isString, includes, some } from 'lodash';
+import { find, get, has, includes, some } from 'lodash';
 import createSelector from 'rememo';
 
 /**
@@ -1605,10 +1605,9 @@ export function __experimentalGetTemplateInfo( state, template ) {
 	const { title: defaultTitle, description: defaultDescription } =
 		__experimentalGetDefaultTemplateType( state, slug );
 
-	const templateTitle = isString( title ) ? title : title?.rendered;
-	const templateDescription = isString( description )
-		? description
-		: description?.raw;
+	const templateTitle = typeof title === 'string' ? title : title?.rendered;
+	const templateDescription =
+		typeof description === 'string' ? description : description?.raw;
 	const templateIcon =
 		__experimentalGetDefaultTemplatePartAreas( state ).find(
 			( item ) => area === item.area
diff --git a/packages/list-reusable-blocks/src/utils/import.js b/packages/list-reusable-blocks/src/utils/import.js
index deee77808ca8c..84c28b5fcfc80 100644
--- a/packages/list-reusable-blocks/src/utils/import.js
+++ b/packages/list-reusable-blocks/src/utils/import.js
@@ -1,8 +1,3 @@
-/**
- * External dependencies
- */
-import { isString } from 'lodash';
-
 /**
  * WordPress dependencies
  */
@@ -31,8 +26,8 @@ async function importReusableBlock( file ) {
 		parsedContent.__file !== 'wp_block' ||
 		! parsedContent.title ||
 		! parsedContent.content ||
-		! isString( parsedContent.title ) ||
-		! isString( parsedContent.content )
+		typeof parsedContent.title !== 'string' ||
+		typeof parsedContent.content !== 'string'
 	) {
 		throw new Error( 'Invalid Reusable block JSON file' );
 	}
diff --git a/packages/redux-routine/src/is-action.js b/packages/redux-routine/src/is-action.js
index f9a430b8b8f9a..bcabab4e07a88 100644
--- a/packages/redux-routine/src/is-action.js
+++ b/packages/redux-routine/src/is-action.js
@@ -1,7 +1,7 @@
 /**
  * External dependencies
  */
-import { isPlainObject, isString } from 'lodash';
+import { isPlainObject } from 'lodash';
 
 /* eslint-disable jsdoc/valid-types */
 /**
@@ -12,7 +12,7 @@ import { isPlainObject, isString } from 'lodash';
  * @return {object is import('redux').AnyAction}  Whether object is an action.
  */
 export function isAction( object ) {
-	return isPlainObject( object ) && isString( object.type );
+	return isPlainObject( object ) && typeof object.type === 'string';
 }
 
 /**